Immunohistochemical distribution of Amyloid Deposits in 25 Cows Diagnosed with Systemic AA Amyloidosis

Yamada, Manabu; Kotani, Yuri; Nakamura, Kikuyasu; Kobayashi, Yoshiyasu; Horiuchi, Noriyuki; Doi, Takuya; Suzuki, Satoshi; Sato, Norihiro; Kanno, Takeshi; Matsui, Takane

doi:10.1292/jvms.68.725

Cited by 38 publications

(23 citation statements)

References 14 publications

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“…Spontaneous AA amyloidosis has been observed in domestic animals and domestic fowl, including beef cattle, Peking ducks, and chickens [17][18][19][20][21][22]. The incidence of amyloidosis in senile cows in Japan has also been examined, and an unexpectedly high incidence of visceral AA-amyloidosis in slaughtered cattle has been reported [17].…”

Section: Discussionmentioning

confidence: 99%

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Acceleration of murine AA amyloid deposition by bovine amyloid fibrils and tissue homogenates

Cui

Kawano

Hoshii

et al. 2008

Amyloid

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Acceleration of amyloid deposition by administration of amyloid fibrils and transmissibility of disease have been reported for several types of amyloidosis. Reactive amyloidosis (AA) occurs in a wide variety of domestic animal species and is characterized by amyloid deposition mainly in spleen, liver, and kidneys. Because the visceral organs of domestic animals have traditionally been used in Asian cuisines, it is important to examine whether dietary ingestion of the organs themselves (rather than purified amyloid fibrils) accelerates AA amyloid deposition. Herein, we show that murine AA amyloidosis develops rapidly after intraperitoneal or oral administration of purified amyloid fibrils or homogenates of amyloid-laden bovine liver. The amyloidosis development in mice was dependent on the concentration of amyloid fibrils or amyloidotic liver homogenates. We found that experimental murine AA amyloidosis was accelerated by dietary ingestion of both purified amyloid fibrils and tissue homogenates that contain amyloid fibrils. We also investigated livers of beef cattle and food chickens to examine whether they contain amyloid-enhancing factor activity. By microscopic examination of hematoxylin and eosin- and Congo red-stained sections, no amyloid deposition was detected in these livers, and no effective activity for experimental induction of AA amyloidosis in mice was detected in homogenates of these livers.

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Section: Discussionmentioning

confidence: 99%

“…AA amyloidosis not only develops in patients with chronic inflammatory or infectious diseases but also develops in various domestic animals, such as cattle, ducks, and chickens [17][18][19][20][21][22]. The livers, intestines, and joints of these animals have traditionally been used in Japanese and other Asian cuisines.…”

Section: Introductionmentioning

confidence: 99%

Acceleration of murine AA amyloid deposition by bovine amyloid fibrils and tissue homogenates

Cui

Kawano

Hoshii

et al. 2008

Amyloid

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“…Amyloidosis was determined in cattle with mastitis, pneumonia, TRP, traumatic pericarditis, salpingitis, and metritis (Johnson & Jamison 1984;Yamada et al 2006). Although amyloidosis was reported in sheep with gangrenous pneumonia, purulent polyarthritis, pseudotuberculosis and abdominal abscess , to the best of our knowledge amyloidosis has not been reported together with TRP .…”

Section: Discussionmentioning

confidence: 99%

Traumatic reticuloperitonitis in a flock of sheep

Baydar

Kulualp

Eröksüz

et al. 2015

Journal of Applied Animal Research

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(The objective of this study was to describe the clinical, ultrasonographical, and pathological findings of traumatic reticuloperitonitis (TRP) with its complications in a flock of sheep. Thirteen sheep in a flock died within one month's duration before two sheep were admitted to the Firat University Veterinary Medical Teaching Hospital. Three additional dead sheep were submitted for necropsy. A tentative diagnosis of TRP on two of the sheep was made based on clinical and ultrasonographic findings. A needle perforating the reticulum was removed from each sheep by surgery. The two sheep improved after the surgery. The necropsy revealed fibrous adhesions and a fistular connection between the dorsoventral face of the reticulum to diaphragma and pericardium with 3 cm syringe needles in the other three sheep. There were congophylic amyloid deposits in the glomerular tufts, Bowman capsule and vascular walls of the liver, kidneys and spleen. Additionally, there was centrilobular necrosis indicating heart failure.Taken together; TRP is rarely seen in sheep; however, TRP and its complications may cause economic losses in sheep flocks. Ultrasonographic examination of the reticular area in sheep may be used as an ancillary diagnostic technique.

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“…It has been reported in domestic animals including canines, felines, porcines, equines, bovines, sheep, goats and certain avian species, but also in wild animals such as black-footed cats, black-footed ferrets, Dorcas gazelles, water fowls, lioness, swans, rhesus and pig-tailed macaques (Rice et al, 2013) or bighorns (reviewed in Woldemeskel, 2012). AAamyloidosis can occur as idiopathic disorders as observed in some Siberian tiggers, cattle or chicken (Kim et al, 2005;Snyder et al, 2011;Steentjes et al, 2002;Yamada et al, 2006;Zekarias et al, 2000); although it normally appears in association with chronic inflammatory processes, viral or bacterial infections or neoplastic diseases (Snyder et al, 2011). For rhesus and pig-tailed macaques, AA-amyloidosis is often detected in individuals suffering from bacterial enterocolitis (Blanchard et al, 1986;Hukkanen et al, 2006;Naumenko and Krylova, 2003;Slattum et al, 1989), rheumatoid arthritis (Chapman and Crowell, 1977), respiratory diseases (Naumenko and Krylova, 2003;Slattum et al, 1989), parasitism (Bacciarini et al, 2004;Blanchard et al, 1986) or even trauma (Slattum et al, 1989); exhibiting prevalence as high as 30% in rhesus macaques (Blanchard et al, 1986), and 47% in pig-tailed macaques (Hukkanen et al, 2006).…”

Section: Aa-amyloidosismentioning

confidence: 99%