Immunohistochemical distribution of enkephalin, substance P, and somatostatin in the brainstem of the leopard frog, Rana pipiens

Stuesse, Sherry L.; Adli, Durriyyah Sharifah Hasan; Cruce, William L.R.

doi:10.1002/jemt.1135

Cited by 22 publications

(18 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A wide distribution of NPFF-ir structures was found with a distribution pattern of immunostaining distinct from that observed for FMRFamide-like immunoreactivity [Pinelli et al, 1999;Rastogi et al, 2001], neuropeptide Y [Danger et al, 1985;Caillez et al, 1987], substance P [Inagaki et al, 1981;Stuesse et al, 2001] or enkephalins [Merchenthaler et al, 1989]. Of note, differences were found in the localization of NPFFir structures between anurans and urodeles, as have also been found among different mammals.…”

Section: Introductionmentioning

confidence: 83%

Distribution of Neuropeptide FF-Like Immunoreactivity in the Brain of Dermophis mexicanus (Amphibia; Gymnophiona): Comparison with FMRFamide Immunoreactivity

et al. 2006

View full text Add to dashboard Cite

Neuropeptide FF (NPFF) is an FMRFamide-related peptide widely distributed in the mammalian brain. NPFF immunohistochemistry labeled cell bodies in a few locations and dense fiber networks throughout the brain. Recently, the distribution of NPFF immunoreactive (NPFF-ir) cells and fibers in the brain of anuran and urodele amphibians was studied and, as in mammals, significant species differences were noted. To further assess general and derived features of the NPFF-containing neuron system in amphibians, we have investigated the distribution of NPFF-ir cell bodies and fibers in the brain of the gymnophionan Dermophis mexicanus by means of an antiserum against bovine NPFF. This distribution was compared to that of FMRFamide immunoreactivity. Major traits shared with anurans and urodeles were the abundant fiber labeling in the ventral telencephalon, hypothalamus, isthmus, ventrolateral medulla and dorsal spinal cord. In addition, in the three amphibian orders the majority of the NPFF-ir cells were located in the preoptic-hypothalamic region. However, distinct particular features were present in the gymnophionan such as the lack of NPFF-ir cells in the telencephalon, brainstem and spinal cord and the absence of NPFF-ir fibers in the hypophysis and the olfactory bulbs. This pattern was distinct from that observed for FMRFamide distribution. Striking differences were noted in the pallium, caudal hypothalamus and midbrain tegmentum where FMRFamide – containing cells were localized. The present results in Dermophis support the idea that data from gymnophionans must be included when stating the amphibian condition of a given system because important variations are obvious when gymnophionans are compared with anurans and urodeles.

show abstract

Section: Introductionmentioning

confidence: 83%

Distribution of Neuropeptide FF-Like Immunoreactivity in the Brain of Dermophis mexicanus (Amphibia; Gymnophiona): Comparison with FMRFamide Immunoreactivity

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Linking these responses to the apparent facilitatory effects of cholinergic activity on the tectum as a whole is difficult at this point. Part of this difficulty comes from the fact that layer six contains many different populations of cells Tostivint et al, 1996;Gabriel et al, 1998;Li and Fite, 1998;Lázár, 2001;Stuesse et al, 2001) and we do not know how any of these cell types function in generating the overall tectal response. Thus it is unclear, for example, how the muscarinic receptor-mediated inhibition of some layer 6 cells will affect overall tectal activity patterns.…”

Section: Understanding the Consequences Of Cholinergic Activitymentioning

confidence: 99%

The effects of nicotinic and muscarinic receptor activation on patch-clamped cells in the optic tectum of rana pipiens

Debski

2003

Neuroscience

View full text Add to dashboard Cite

Both nicotinic and muscarinic cholinergic receptors are present in the optic tectum. To begin to understand how the activation of these receptors affects visual activity patterns, we have determined the types of physiological responses induced by their activation. Using tectal brain slices from the leopard frog, we found that application of nicotine (100 μM) evoked long-lasting responses in 60% of patch-clamped tectal cells. Thirty percent of these responses consisted of an increase in spontaneous postsynaptic currents (sPSCs) and had both a glutamatergic and GABAergic component as determined by the use of 6-cyano-7-nitroquinoxaline-2,3-dione (50 μM) and bicuculline (25 μM), respectively. Remaining response types consisted of an inward membrane current (16%) and an increase in sPSCs combined with an inward membrane current (14%). All responses could be elicited in the presence of tetrodotoxin (0.5 μM). Muscarinic receptor-mediated responses, induced by carbachol (100 μM) application after nicotinic receptor desensitization, produced responses in 70% of tectal cells. In contrast to responses elicited by nicotine, carbachol-induced responses could be evoked multiple times without significant decrement. Responses consisted of either an outward current (57%), a decrease in sPSCs (5%) or an increase in sPSCs, with (almost 6%) or without (almost 3%) an outward current. The response elicited by carbachol was not predicted by the response of the cell to nicotine.Our results suggest that nicotinic receptors are found predominantly at presynaptic locations in the optic tectum while muscarinic receptors are most often present at postsynaptic sites. We conclude that both of these receptor types could substantially modulate visual activity by changing either the input to tectal neurons or the level of their response to that input. Keywords frog; retinotectal; acetylcholine; visual system; cholinergic; superior colliculus Acetylcholine (ACh) is present in many regions throughout the visual system appearing in the retina, superior colliculus, lateral geniculate nucleus, suprachiasmatic nuclei and the visual cortex (Groos et al., 1983;Sastry, 1985;Hohmann and Berger-Sweeney, 1998;Bickford et al., 2000). Contributed by both intrinsic and extrinsic sources (Sherman and Koch, 1986;Nobili and Sannita, 1997;Binns, 1999), cholinergic activity influences system function, plasticity and development (Greuel et al., 1988;Hohmann and Berger-Sweeney, 1998;Lauder and Schambra, 1999). Disturbances of this activity can result in such things as delayed neuronal development, changes in cytoarchitecture (Hohmann and Berger-Sweeney, 1998;Lauder and Schambra, 1999) and impaired ocular dominance shifts (Bear and Singer, 1986;Gordon et al., 1990). However, how ACh affects system activity and contributes to the mechanisms responsible for normal brain organization is not understood. The optic tectum of the frog provides an attractive model system for examining the ways in which cholinergic activity modulates visual system function and plastici...

show abstract

“…Nomenclature used to refer to neuroanatomical regions was based on the work of Herrick [1927], Northcutt and Kicliter [1980], Roth [1987], Schmidt and Roth [1990], Marin et al [1997a, b], Sanchez-Camacho et al [2001], and Stuesse et al [2001].…”

Section: Methodsmentioning

confidence: 99%

“…Specifi cally, in the rostral area of the hindbrain, CB1 ISH labeling occurred in cells of the stratum griseum [Herrick, 1914]. However, this labeling was only in the very medial region of the raphe nucleus [Sanchez-Camacho et al, 2001], more specifi cally, at the location of the raphe magnus, just dorso-medial to the griseum centrale rhombencephali [Stuesse et al, 2001], and medial to the locus coeruleus [Marin et al, 1997a, b]. At a slightly more caudal level of the rostral medulla, CB1 ISH labeling extended through cells of the stratum griseum, with the exception of the area acousticolateralis.…”

mentioning

confidence: 99%

“…At a slightly more caudal level of the rostral medulla, CB1 ISH labeling extended through cells of the stratum griseum, with the exception of the area acousticolateralis. More specifi cally, CB1 ISH labeling occurred in the raphe nucleus [SanchezCamacho et al, 2001], in the raphe magnus, again just dorsal-medial to the griseum centrale rhombencephali [Stuesse et al, 2001]. CB1 ISH labeling also occurred in the nucleus reticularus medius, in the motor nucleus of the tegmentum.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Neuroanatomical Distribution of Cannabinoid Receptor Gene Expression in the Brain of the Rough-Skinned Newt, Taricha granulosa

Hollis

Coddington²,

Moore³

2006

Brain Behav Evol

View full text Add to dashboard Cite

Type I cannabinoid receptor (CB1) is a G-protein coupled receptor with a widespread distribution in the central nervous system in mammals. In a urodele amphibian, the rough-skinned newt (Taricha granulosa), recent evidence indicates that endogenous cannabinoids (endocannabinoids) mediate behavioral responses to acute stress and electrophysiological responses to corticosterone. To identify possible sites of action for endocannabinoids, in situ hybridization using a gene and species specific cRNA probe was used to label CB1 mRNA in brains of male T. granulosa. Labeling of CB1 mRNA in the telencephalon was observed in the olfactory bulb and all areas of the pallium, as well as the bed nucleus of the stria terminalis and nucleus amygdalae dorsolateralis. The labeling of CB1 mRNA was also found in regions of the preoptic area, thalamus, midbrain tegmentum and tectum, cerebellum, and the stratum griseum of the hindbrain. A notable difference in CB1 labeling between this amphibian and mammals is the abundance of labeling in areas associated with olfaction (anterior olfactory nuclei, nucleus amygdalae dorsolateralis, and lateral pallium), which hints that endocannabinoids might modulate responses to odors as well as pheromones. This widespread distribution of CB1 labeling, particularly in sensory and motor control centers, fits with prior results showing that endocannabinoids modulate sensorimotor processing and behavioral output in this species. The distribution of CB1 in the brain of T. granulosa was in many of the same sites previously observed in the brain of the anuran amphibian, Xenopus laevis, as well as those of different species of mammals, suggesting that endocannabinoid signaling pathways are conserved.

show abstract

Immunohistochemical distribution of enkephalin, substance P, and somatostatin in the brainstem of the leopard frog, Rana pipiens

Cited by 22 publications

References 91 publications

Distribution of Neuropeptide FF-Like Immunoreactivity in the Brain of <i>Dermophis mexicanus</i> (Amphibia; Gymnophiona): Comparison with FMRFamide Immunoreactivity

Distribution of Neuropeptide FF-Like Immunoreactivity in the Brain of <i>Dermophis mexicanus</i> (Amphibia; Gymnophiona): Comparison with FMRFamide Immunoreactivity

The effects of nicotinic and muscarinic receptor activation on patch-clamped cells in the optic tectum of rana pipiens

Neuroanatomical Distribution of Cannabinoid Receptor Gene Expression in the Brain of the Rough-Skinned Newt, <i>Taricha granulosa</i>

Contact Info

Product

Resources

About