2002
DOI: 10.1111/j.1348-0421.2002.tb02660.x
|View full text |Cite
|
Sign up to set email alerts
|

Immunohistochemical Distribution of Epithelioid Cell, Myofibroblast, and Transforming Growth Factor‐β1 in the Granuloma Caused by Mycobacterium avium intracellulare Complex Pulmonary Infection

Abstract: The present study was designed to evaluate the distribution of epithelioid cells, myofibroblasts, and TGF‐β1 in the formation of granuloma caused by Mycobacterium avium intracellulare complex (MAC) lung infection. A retrospective study was performed for 9 cases of positive MAC culture in which lung resections were performed between January 1989 and August 1999. Resected lung specimens were evaluated histologically and immunohistochemically for CD68 (stain for monocytes and macrophages, and epithelioid cells) a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

1
15
0

Year Published

2002
2002
2023
2023

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 14 publications
(16 citation statements)
references
References 25 publications
1
15
0
Order By: Relevance
“…This is the first study showing the presence of myofibroblasts in granulomas of various types of granulomatous lung diseases and is in line with the previous study showing that myofibroblasts are present around granulomas in MAC infection [2]. Myofibroblasts were also observed in the same areas than tenascin-C and precursor proteins of collagens I and III, which suggest that myofibroblasts produce these ECM proteins.…”
Section: Discussionsupporting
confidence: 90%
See 2 more Smart Citations
“…This is the first study showing the presence of myofibroblasts in granulomas of various types of granulomatous lung diseases and is in line with the previous study showing that myofibroblasts are present around granulomas in MAC infection [2]. Myofibroblasts were also observed in the same areas than tenascin-C and precursor proteins of collagens I and III, which suggest that myofibroblasts produce these ECM proteins.…”
Section: Discussionsupporting
confidence: 90%
“…Several ECM-controlling cytokines, such as interferon-c, interleukin-4, tumor necrosis factor a, and transforming growth factor-b (TGF-b) are expressed in granulomas [1,2]. In addition to macrophages, lymphocytes, epitheloid cells, and multinucleated giant cells, myofibroblast-type cells are expressed in granulomas of Mycobacterium avium intracellular complex (MAC) pulmonary infection [2].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…In sarcoidosis, the positive cells for collagen I and III mRNA localized mainly around granulomas. This finding is interesting since in mycobacterium avium intracellulare complex myofibroblasts could be detected around the granulomas of pulmonary infection (Fujita et al 2002). The difference in the accumulation of type I pN-collagen and type III pN-collagen around inflammatory cells is also interesting.…”
Section: Discussionmentioning
confidence: 94%
“…In the present study, werevealed a layer of myofibroblasts around the outer zone of epithelioid cells in the cavitary lesion and caseous necrotic granuloma. In addition, we have demonstrated the expression of transforming growth factor (TGF)-p l (which is a well knowncytokine to induce myofibroblasts (1 1)) in epithelioid cells and multinucleated giant cells (12). These findings suggest that within the infected focus, myofibroblasts differentiated from fibroblasts by TGF-(3 may play a role by encapsulating MACand by inhibiting the spread of MAC.…”
Section: Discussionmentioning
confidence: 88%