Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain

Francke, Felix; Richter, Dietmar; Bächner, Dietmar

doi:10.1016/j.molbrainres.2005.05.005

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…While MCHR1 is believed to be the sole MCH receptor in rodents, it is possible that there are other receptors that are not yet known, or that MCHR1 may have additional ligands. In fact, the distribution of MCHR1 in the brain (Francke et al, 2005) is quite different from the distribution of MCH itself (Bittencourt et al, 1992, Bittencourt, 2011), and MCH neurons are known to contain other neurotransmitters, such as glutamate (Chee et al, 2015). In summary, the chemogenetic activation of MCH neurons is more likely to mimic the in vivo neuronal firing pattern and reflect the physiological role of MCH neurons than is the exogenous application of MCH peptide or MCHR1 antagonists.…”

Section: Discussionmentioning

confidence: 99%

Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice

et al. 2016

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Currently available evidence indicates that neurons containing melanin-concentrating hormone (MCH) in the lateral hypothalamus are critical modulators of sleep-wakefulness, but their precise role in this function is not clear. Studies employing optogenetic stimulation of MCH neurons have yielded inconsistent results, presumably due to differences in the optogenetic stimulation protocols, which do not approximate normal patterns of cell firing. In order to resolve this discrepancy, we 1) selectively activated the MCH neurons using a chemogenetic approach (Cre-dependent hM3Dq expression) and 2) selectively destroyed MCH neurons using a genetically targeted diphtheria toxin deletion method, and studied the changes in sleep-wake in mice. Our results indicate that selective activation of MCH neurons causes specific increases in rapid eye movement (REM) sleep without altering wake or non-REM (NREM) sleep. On the other hand, selective deletions of MCH neurons altered the diurnal rhythm of wake and REM sleep without altering their total amounts. These results indicate that activation of MCH neurons primarily drives REM sleep and their presence may be necessary for normal expression of diurnal variation of REM sleep and wake.

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Section: Discussionmentioning

confidence: 99%

Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice

et al. 2016

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“…Peptide YY (PYY) expression has been reported to be restricted to the sustentacular cells even though, quite interestingly, a targeted deletion of the peptide results in an increased expression of OSNs where it might play a role in neuronal differentiation (Doyle et al, 2012). In the OB, for example, mitral cells strongly express the melanin-concentrating hormone receptor (MCHR; Scalera and Tarozzi 1998;Hervieu et al 2000;Francke et al 2005;Lepousez et al 2010), the glucagon-like peptide (GLP-1) receptor (protein plus mRNA; Merchentaler et al 1999b), and the bombesin neuromedin B (Ohki-Hamazaki, 2000).…”

Section: Further Metabolic Factorsmentioning

confidence: 99%

Olfaction Under Metabolic Influences

et al. 2012

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Recently published work and emerging research efforts have suggested that the olfactory system is intimately linked with the endocrine systems that regulate or modify energy balance. Although much attention has been focused on the parallels between taste transduction and neuroendocrine controls of digestion due to the novel discovery of taste receptors and molecular components shared by the tongue and gut, the equivalent body of knowledge that has accumulated for the olfactory system, has largely been overlooked. During regular cycles of food intake or disorders of endocrine function, olfaction is modulated in response to changing levels of various molecules, such as ghrelin, orexins, neuropeptide Y, insulin, leptin, and cholecystokinin. In view of the worldwide health concern regarding the rising incidence of diabetes, obesity, and related metabolic disorders, we present a comprehensive review that addresses the current knowledge of hormonal modulation of olfactory perception and how disruption of hormonal signaling in the olfactory system can affect energy homeostasis.

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“…MCH-containing neurons originate in the lateral hypothalamus and the adjacent zona incerta and project throughout the brain (Bittencout and Elias, 1998 ;Bittencourt et al, 1992 ;Cvetkovic et al, 2003 ;Francke et al, 2005 ;Haarthoorn, 2007). Accordingly, MCH is implicated in many physiological functions, including energy homeostasis (Forray, 2003 ;Hervieu et al, 2000 ;Hervieu, 2006 ;Marsh et al, 2002 ;Pissios et al, 2006 ;Qu et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

The melanin-concentrating hormone1 receptor antagonists, SNAP-7941 and GW3430, enhance social recognition and dialysate levels of acetylcholine in the frontal cortex of rats

Millan

Gobert

Panayi

et al. 2008

Int. J. Neuropsychopharm.

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Melanin-concentrating hormone (MCH)1 receptors are widely expressed in limbic structures and cortex. Their inactivation is associated with anxiolytic and antidepressive properties but little information is available concerning cognition. This issue was addressed using the selective antagonists, SNAP-7941 and GW3430, in a social recognition paradigm in rats. The muscarinic blocker, scopolamine (1.25 mg/kg s.c.), reduced social recognition, an action dose-dependently blocked by SNAP-7941 and GW3430 (0.63-10.0 and 20.0-80.0 mg/kg i.p., respectively) which did not themselves display amnesic properties. Further, in a protocol where a spontaneous deficit was induced by a prolonged inter-session delay, SNAP-7941 and GW3430 dose-dependently enhanced social recognition. In dialysis studies, SNAP-7941 (0.63-40.0 mg/kg i.p.) and GW3430 (10.0-40.0 mg/kg i.p.) elevated extracellular levels of acetylcholine (ACh) in the frontal cortex (FCX) of freely moving rats. The SNAP-7941 effect was specific, as it did not increase levels of ACh in ventral and dorsal hippocampus: moreover, it did not modify levels of noradrenaline, dopamine, serotonin and glutamate in FCX. Active doses of SNAP-7941 and GW3430 corresponded to doses (2.5-40.0 and 10.0-80.0 mg/kg i.p., respectively) exerting anxiolytic properties in Vogel conflict and ultrasonic vocalization tests, and antidepressant actions in forced swim, isolation-induced aggression and marble-burying procedures. In contrast to SNAP-7941 and GW3430, the benzodiazepine, diazepam, decreased social recognition and dialysate levels of ACh, while the tricyclic, imipramine, reduced social recognition and failed to enhance cholinergic transmission. In conclusion, at anxiolytic and antidepressant doses, SNAP-7941 and GW3430 improve social recognition and elevate extracellular ACh levels in FCX. This profile differentiates MCH1 receptor antagonists from conventional anxiolytic and antidepressant agents.

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Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain

Cited by 6 publications

References 36 publications

Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice

Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice

Olfaction Under Metabolic Influences

The melanin-concentrating hormone1 receptor antagonists, SNAP-7941 and GW3430, enhance social recognition and dialysate levels of acetylcholine in the frontal cortex of rats

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