Immunohistochemical expression of AQP-3 in vitiligo: a new potential guide for disease activity

Hodeib, Abeer A; Hegab, Doaa Salah; Rizk, Omnia; S, Mohammed

doi:10.23736/s0392-0488.16.05248-2

Cited by 4 publications

(3 citation statements)

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“…E‐cadherin adhesion is rather weak in active vitiligo skin and has a higher expression in active compared to stable vitiligo 28 . Both aquaporin‐3 and glutathione peroxidase (GPX1) are decreased in active vitiligo compared to stable vitiligo skin 56,57 . Table 1 and Figure 1 provide an overview of the tissue makers associated with disease activity.…”

Section: Resultsmentioning

confidence: 99%

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Biomarkers and clinical indicators of disease activity in vitiligo

Delbaere

Speeckaert

Herbelet

et al. 2022

Dermatological Reviews

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Background:The management of vitiligo is guided by the assessment of disease activity. However, this assessment is hampered by the absence of a highly feasible and reliable single marker to evaluate activity. Furthermore, the need for an objective, easy, preferably noninvasive marker is further stressed by the increased amount of research performed on new treatment strategies for vitiligo.Objectives: In this review, the available research on clinical signs linked to disease activity, and biomarkers in tissues and blood are summarized.Results: In the group of clinical signs, the Koebner phenomenon has the strongest evidence of an association with disease activity, while confetti-like depigmentation is gaining importance and seems to outweigh this role. For the tissue markers, the most evidence is available for histopathological findings, such as epidermal spongiosis with vacuolar degeneration in the basal cells and inflammatory infiltrate. Circulating biomarkers such as interleukin-1β (IL-1β), IL-17, interferon-γ, tumor growth factor-β, soluble cluster of differentiation 25, autoantibodies, and oxidative stress markers show the most promising results. Nevertheless, none of them are currently regarded as the gold standard.Discussion: In conclusion, we encourage researchers to investigate various biomarkers and clinical signs in their trials in a standardized manner to get insight into their exact value, so they can be used to optimize treatment selection, gain insight into the disease, and predict future disease progression.

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Section: Resultsmentioning

confidence: 99%

“…28 Both aquaporin-3 and glutathione peroxidase (GPX1) are decreased in active vitiligo compared to stable vitiligo skin. 56,57 Table 1 and Figure 1 provide an overview of the tissue makers associated with disease activity.…”

Section: Histopathologic Findingsmentioning

confidence: 99%

Biomarkers and clinical indicators of disease activity in vitiligo

Delbaere

Speeckaert

Herbelet

et al. 2022

Dermatological Reviews

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“…Hodeib et al . [ 7 ] in a recent study have shown a reduced immunohistochemical expression of AQP3 in vitiligo epidermis than in controls with an inverse correlation with VIDA, implicating AQP3 as a potential negative biological marker for vitiligo activity. In our study, in addition to reduction in tissue AQP3 levels in vitiligo we observed that plasma AQP3 levels were also reduced in vitiligo in comparison to controls and also correlating with disease severity suggesting a systemic AQP3 deficiency in vitiligo which has not been reported previously.…”

Section: Discussionmentioning

confidence: 99%

Is vitiligo associated with systemic aquaporin-3 deficiency?

Chandrashekar

Rajappa

Rajendiran

et al. 2021

pdia

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Introduction: Recent studies on pathomechanisms of vitiligo have focused on the abnormality of keratinocytes that affect the melanocytes. Aquaporin-3 (AQP3) was implicated as a mechanism for keratinocyte apoptosis owing to the relationship between the PI3K/AKT pathway and the E-cadherin-catenin complex. Aim: Based on this evidence, we undertook a cross-sectional study to assess the skin and blood AQP-3 levels in patients with non-segmental vitiligo in comparison to controls and to correlate these levels with malondialdehyde (MDA) levels and total antioxidant status (TAS) in the skin and blood of patients with non-segmental vitiligo and also with their disease activity. Material and methods: Thirty-six patients with non-segmental vitiligo and 36 controls were included in this study. AQP3, TAS and MDA levels were assayed both in skin as well as in circulation. Results: We observed that skin and plasma aquaporin and TAS were lowered and MDA levels were increased in patients with non-segmental vitiligo as compared to controls. There was a significant negative correlation of skin and plasma aquaporin levels with disease activity. We also observed the local and systemic AQP3 deficiency to correlate with the local and systemic oxidative stress in vitiligo. Conclusions: Our results demonstrate a systemic and local AQP3 deficiency in vitiligo correlating with the disease severity and oxidative stress which might have therapeutic implications.

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Indirect Proton MR Imaging and Kinetic Analysis of <sup>17</sup>O-Labeled Water Tracer in the Brain

Kudo

Harada

Kameda

et al. 2018

MRMS

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Purpose:The feasibility of steady-state sequences for 17O imaging was evaluated based on a kinetic analysis of the brain parenchyma and cerebrospinal fluid (CSF).Materials and Methods:The institutional review board approved this prospective study with written informed consent. Dynamic 2D or 3D steady-state sequences were performed in five and nine participants, respectively, with different parameters using a 3T scanner. During two consecutive dynamic scans, saline was intravenously administered for control purposes in the first scan, and 20% 17O-labeled water (1 mL/Kg) was administered in the second scan. Signal changes relative to the baseline were calculated, and kinetic analyses of the curves were conducted for all voxels. Region of interest analysis was performed in the brain parenchyma, choroid plexus, and CSF spaces.Results:Average signal drops were significantly larger in the 17O group than in the controls for most of the imaging parameters. Different kinetic parameters were observed between the brain parenchyma and CSF spaces. Average and maximum signal drops were significantly larger in the CSF spaces and choroid plexus than in the brain parenchyma. Bolus arrival, time to peak, and the first moment of dynamic curves of 17O in the CSF space were delayed compared to that in the brain parenchyma. Significant differences between the ventricle and subarachnoid space were also noted.Conclusion:Steady-state sequences are feasible for indirect 17O imaging with reasonable temporal resolution; this result is potentially important for the analysis of water kinetics and aquaporin function for several disorders.

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Immunohistochemical expression of AQP-3 in vitiligo: a new potential guide for disease activity

Cited by 4 publications

References 0 publications

Biomarkers and clinical indicators of disease activity in vitiligo

Biomarkers and clinical indicators of disease activity in vitiligo

Is vitiligo associated with systemic aquaporin-3 deficiency?

Indirect Proton MR Imaging and Kinetic Analysis of <sup>17</sup>O-Labeled Water Tracer in the Brain

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