Immunohistochemical Expression of C-Kit in Oral Squamous Cell Carcinoma Patients in South Indian Populations

Abstract

Objective: The study was designed to evaluate the C-Kit expression and also to assess the relationship with various clinicopathological characteristics in oral squamous cell carcinoma (OSCC) patients.Methods: A total number of 102 formalin-fixed paraffin-embedded retrospective tissue samples were collected, in which (n =84) were histologically confirmed for OSCC, oral epithelial dysplasia (OED) (n=9), and control group (n=10) and studied immunohistochemically. The baseline characters and the correlation between the protein expression and clinicopathological parameters were analyzed. The survival analysis was performed using Kaplan-Meier Survival Method.Results: OSCC exhibited C-Kit protein expression positivity of 6% and OED with 11.11% with no expression of this protein in control patients. Overall survival analysis showed that patients with negative expression had a better survival than patients with positive expression. However, we found that expression pattern of C-kit did not correlate with various clinicopathological characteristics.Conclusion: Vast amount of study has to be still performed to under the mechanism of OSCC in C-KIT Expression to enhance the prognosis of OSCC patients in the near future.

Resistin Gene Polymorphisms: Potential Biomarker for Oral Squamous Cell Carcinoma

“…A previous study revealed that the presence of the polymorphic allele of RETN rs3219175 had marked effects on plasma resistin in patients with type 2 diabetes (35). Another study reported that rs3219175 SNPs were significantly associated with log-resistin levels in Malaysian population [36][37][38].…”