Immunohistochemical expression of Epidermal Growth Factor Receptor (EGFR) in canine mammary tissues

Gama, Adelina; Gärtner, Fátima; Alves, Anabela; Schmitt, Fernando

doi:10.1016/j.rvsc.2009.04.016

Cited by 71 publications

(94 citation statements)

References 32 publications

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“…Factors which may play a significant role in the appearance and development of various genital pathologies in bitches, manifesting autocrine and paracrine activity, include also growth factors and their receptors (growth factors receptors, GFs), (Gama et al 2009). These may stimulate cell growth and proliferation and may inhibit apoptotic processes and stimulate neoangiogenesis, in this way also being potentially involved in pathogenesis of mammary tumours.…”

Section: The Role Of Growth Factors In the Pathogenesis Of Endometritmentioning

confidence: 99%

Endometritis and pyometra in bitches: a review

Kempisty¹,

Bukowska²,

Woźna³

et al. 2013

Vet. Med.

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Endometritis-pyometra is the most frequent and complex pathology in domestic bitches. This process involves several immunological changes as well as molecular mechanisms responsible for inflammation in the female uterus. The various clinical stages of pyometra are associated with various symptoms. In this review, several aspects are described, including physiological and pathological mechanisms as well as molecular changes which take place during induction of endometritis-pyometra. The authors also highlight the important role of growth factors and their receptors in this process. It is well known that pyometra is a compound process which mainly involves immunological changes during inflammation. However, this review presents a new overview of this process, which includes changes at the molecular level, e.g., the altered expression of genes crucial for the development of this disease. Although pyometra is the most frequent disease of the reproductive tract in bitches, the molecular basis of this process is still not entirely understood.

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Section: The Role Of Growth Factors In the Pathogenesis Of Endometritmentioning

confidence: 99%

Endometritis and pyometra in bitches: a review

Kempisty¹,

Bukowska²,

Woźna³

et al. 2013

Vet. Med.

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“…Expression of its receptor was observed in most studied cases of squamous skin cancers in cats -it correlated with shorter life expectancy but not with the tumour's mitotic activity (29). Incorrect activation of the EGFR receptor was also identified in epithelial tumours with high metastatic potential located in the lungs, nasal cavity and mamma in dogs (30)(31)(32) and oral cavity in cats (33).…”

Section: Discussionmentioning

confidence: 99%

Elevated EGF Levels in the Blood Serum of Dogs with Periodontal Diseases and Oral Tumours

Sobczyńska-Rak

Żylińska

Polkowska

et al. 2018

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“…In domestic animals, EGFR immunostaining has been reported in canine breast tumors (GAMA et al, 2009), primary brain tumors (LIU et al, 2001), nasal carcinomas (SHIOMITSU et al, 2009), lung carcinomas (SABATTINI et al, 2014, and gastric tumors (TERRAGNI et al, 2014). Likewise, cases of Her2 overexpression were reported in 19-35% of canine mammary tumors (HSU et al, 2009;RESSEL et al, 2013), and in 57.9% of canine gastric neoplasms (TERRAGNI et al, 2014).…”

Section: Faleiro Et Almentioning

confidence: 99%

Expression of EGF receptors in canine prostate with proliferative inflammatory atrophy and carcinoma

Faleiro¹,

Cintra

Jesuino

et al. 2017

Cienc. Rural

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Gene expression of ErbB1 and ErbB2, and immunostaining of EGFR (Her1) and Her2 (c-erbB-2) were evaluated in this study to ascertain whether these receptors are involved in the evolution of canine premalignant and malignant prostatic lesions, as proliferative inflammatory atrophy (PIA) and prostatic carcinoma (PC). With regards to the intensity of EGFR immunostaining, there was no difference between normal prostatic tissue and tissues with PIA or PC. In relation to Her2 immunostaining, there were differences between normal prostatic tissue and those with PIA and PC, as also differences between prostates with PIA and PC. There was no correlation between EGFR and Her2 immunostaining. ErbB1 gene product was detected in two normal tissue samples, in one with PIA, and in all samples with PC. ErbB2 mRNA was recorded in two canine samples with PIA, in all with PC, but was not detected in normal prostatic tissue. It was concluded that EGFR and Her2 play roles in canine PIA and PC, suggesting that those receptors may be involved in canine prostatic carcinogenesis.

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Immunohistochemical expression of Epidermal Growth Factor Receptor (EGFR) in canine mammary tissues

Cited by 71 publications

References 32 publications

Endometritis and pyometra in bitches: a review

Endometritis and pyometra in bitches: a review

Elevated EGF Levels in the Blood Serum of Dogs with Periodontal Diseases and Oral Tumours

Expression of EGF receptors in canine prostate with proliferative inflammatory atrophy and carcinoma

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