Immunohistochemical Expression of Estrogen Receptors in Chondrosarcomas and Enchondromas

Grifone, Thomas J.; Haupt, Helen M.; Podolski, Victoria; Brooks, John J.

doi:10.1177/1066896907306774

Cited by 23 publications

(13 citation statements)

References 18 publications

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“…At the cellular level, the estrogen effect is mediated by the estrogen receptor (ER), because mRNA expression and nuclear immunoreactivity for ER have been shown in chondrocytes as well as CS cells (36,37). Furthermore, the expression of CYP19 mRNA, the gene encoding aromatase, which converts androstenedione to estrogen, has been shown in both normal and neoplastic cartilaginous tissue (38).…”

Section: Discussionmentioning

confidence: 99%

Age-Period-Cohort Analysis of Primary Bone Cancer Incidence Rates in the United States (1976–2005)

Anfinsen

Devesa

Bray

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Primary bone cancer comprises three major histologic types: osteosarcoma (OS), Ewing sarcoma (ES), and chondrosarcoma (CS). Given the limited knowledge about the etiology of primary bone cancer, we undertook an age-period-cohort (APC) analysis to determine whether incidence varied by birth cohort or calendar period. The purpose was to examine the temporal development of each bone cancer type and generate etiologic hypotheses via the observed birth cohort-related changes.Methods: An APC model was fitted to incidence data for U.S. whites for OS, ES, and CS obtained from nine registries of the Surveillance, Epidemiology, and End Results program, which covers about 10% of the U. S. population, 1976-2005.Results: The incidence of OS decreased between 1976 and 2005 among those aged over 60 years, a decline that occurred among patients with OS as their primary malignancy only. From 1986From -1995From to 1996From -2005, the incidence rate of CS among females of 20 to 69 years rose by about 50%, with rates increasing among consecutive cohorts born during . CS rates among males were stable, as were rates of ES.Conclusion: The risk reduction in OS as a primary malignancy at older ages could possibly be related to diminished exposure over time to bone-seeking radionuclides. The CS increase among females corresponds to birth cohorts with rising exposures to oral contraceptives and menopausal hormonal therapy.Impact: As the estrogen signaling pathway has been shown to stimulate proliferation of normal and malignant chondrocytes, estrogen exposure may increase the risk for CS. Further studies are warranted to clarify its possible etiological significance. Cancer Epidemiol Biomarkers Prev; 20(8); 1770-7. Ó2011 AACR.

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Section: Discussionmentioning

confidence: 99%

Age-Period-Cohort Analysis of Primary Bone Cancer Incidence Rates in the United States (1976–2005)

Anfinsen

Devesa

Bray

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Sex steroids are also likely involved in this process; their role in the pubertal growth spurt and subsequent epiphyseal fusion is well-established [8]. Furthermore, both in vivo expression of oestrogen receptors as well as in vitro oestrogen/induced proliferation-survival have been previously shown in cartilaginous tumours [9,10]. However, clear understanding of the genetic mechanism driving the pathogenesis of chondroblastoma is lacking.…”

Section: Introductionmentioning

confidence: 99%

A balanced t(5;17) (p15;q22-23) in chondroblastoma: frequency of the re-arrangement and analysis of the candidate genes

Romeo

Szuhai

Nishimori³

et al. 2009

BMC Cancer

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BackgroundChondroblastoma is a benign cartilaginous tumour of bone that predominantly affects the epiphysis of long bones in young males. No recurrent chromosomal re-arrangements have so far been observed. Methods: We identified an index case with a balanced translocation by Combined Binary Ratio-Fluorescent in situ Hybridisation (COBRA-FISH) karyotyping followed by breakpoint FISH mapping and array-Comparative Genomic Hybridisation (aCGH). Candidate region re-arrangement and candidate gene expression were subsequently investigated by interphase FISH and immunohistochemistry in another 14 cases.ResultsA balanced t(5;17)(p15;q22-23) was identified. In the index case, interphase FISH showed that the translocation was present only in mononucleated cells and was absent in the characteristic multinucleated giant cells. The t(5;17) translocation was not observed in the other cases studied. The breakpoint in 5p15 occurred close to the steroid reductase 5α1 (SRD5A1) gene. Expression of the protein was found in all cases tested. Similar expression was found for the sex steroid signalling-related molecules oestrogen receptor alpha and aromatase, while androgen receptors were only found in isolated cells in a few cases. The breakpoint in 17q22-23 was upstream of the carbonic anhydrase × (CA10) gene region and possibly involved gene-regulatory elements, which was indicated by the lack of CA10 protein expression in the index case. All other cases showed variable levels of CA10 expression, with low expression in three cases.ConclusionWe report a novel t(5;17)(p15;q22-23) translocation in chondroblastoma without involvement of any of the two chromosomal regions in other cases studied. Our results indicate that the characteristic multinucleated giant cells in chondroblastoma do not have the same clonal origin as the mononuclear population, as they do not harbour the same translocation. We therefore hypothesise that they might be either reactive or originate from a distinct neoplastic clone, although the occurrence of two distinct clones is unlikely. Impairment of the CA10 gene might be pathogenetically relevant, as low expression was found in four cases. Diffuse expression of SRD5A1 and sex steroid signalling-related molecules confirms their role in neoplastic chondrogenesis.

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“…Placental and fetal metastasising of chondrosarcomas of the extremities has not been reported to date. An adverse effect of altered maternal hormone levels on tumour growth however cannot be ruled out until today 5 6. Therefore, a treatment with the least achievable delay appears to be necessary.…”

Section: Discussionmentioning

confidence: 99%

“…As a result there are neither rich experiences nor common treatment rationale for women diagnosed with chondrosarcoma of the extremities during pregnancy. In addition it still remains unclear whether chondrosarcoma may show progression or dedifferentiation according to the patient's hormone status 2 5 6…”

Section: Introductionmentioning

confidence: 99%

Chondrosarcoma of the tibial head during pregnancy: a challenging diagnosis

et al. 2014

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SUMMARYChondrosarcoma is one of the most common malignant bone tumours in adults. However, it rarely occurs during pregnancy. Therefore, reports on surgical and medical management of this entity are hard to find. Different studies suggest a possible growth-enhancing effect of altered hormone levels on various bone tumours. The effect of pregnancy on growth characteristics of chondrosarcomas however remains unclear. We report a case of a 32-year-old pregnant woman with a newly occurred chondrosarcoma of the tibial head. Intense clinical monitoring and repeated MRI scans showed a tumour progression during pregnancy followed by the need of above-knee amputation after 30 weeks gestation. Spontaneous vaginal delivery after 38 weeks gestation was complicated by an amniotic infection syndrome and finally stopped, necessitating a caesarean section. Despite this there were no further complications to be mentioned. No local tumour recurrence or metastases could be detected in the staging CT scans following pregnancy. BACKGROUND

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Immunohistochemical Expression of Estrogen Receptors in Chondrosarcomas and Enchondromas

Cited by 23 publications

References 18 publications

Age-Period-Cohort Analysis of Primary Bone Cancer Incidence Rates in the United States (1976–2005)

Age-Period-Cohort Analysis of Primary Bone Cancer Incidence Rates in the United States (1976–2005)

A balanced t(5;17) (p15;q22-23) in chondroblastoma: frequency of the re-arrangement and analysis of the candidate genes

Chondrosarcoma of the tibial head during pregnancy: a challenging diagnosis

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