Immunohistochemical expression of estrogen receptors alpha and beta in lobular neoplasia

Nonni, Afrodite; Zagouri, Flora; Sergentanis, Theodoros N.; Lazaris, Andreas C.; Patsouris, Efstratios; Zografos, George

doi:10.1007/s00428-007-0504-6

Cited by 8 publications

(11 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A few recent studies have examined ER expression in lobular neoplasia. (19–20) Nonni and colleagues(19) examined ER expression in 30 patients with either lobular carcinoma in situ and/or atypical lobular hyperplasia, but the exact number of patients with each lesion is unknown. They found that in all 30 samples, areas of lobular neoplasia demonstrated ER alpha staining, both by percent cells positive (mean 68%) and by Allred score (mean 6.9).…”

Section: Discussionmentioning

confidence: 99%

Estrogen Receptor Expression in Atypical Hyperplasia: Lack of Association with Breast Cancer

Barr

Degnim

Hartmann

et al. 2011

Cancer Prevention Research

View full text Add to dashboard Cite

Estrogen receptor (ER) is expressed in normal and malignant breast epithelium, and expression levels have been found to increase with age in normal breast epithelium but not in atypical hyperplasia (AH) and carcinoma in situ. Here we assess ER expression in AH and its association with later breast cancer. ER expression was assessed immunohistochemically in archival sections from 246 women with AH who had open benign breast biopsy from 1967 to 1991. The ACIS III (Dako) was utilized to calculate ER expression in all atypical foci. Using multivariate linear regression, we examined associations of ER expression with age at biopsy, indication for biopsy, type of atypia, number of atypical foci, involution status, and family history. Breast cancer risk across levels of ER expression was also assessed compared with the Iowa SEER control population. Among 246 women, 87 (35%) had atypical ductal hyperplasia (ADH), 141 (57%) had atypical lobular hyperplasia (ALH), and 18 (7%) had both. Forty-nine (20%) developed breast cancer (median follow-up of 14.4 years). Multivariate analysis indicated that type of atypia and age at diagnosis were significantly associated with ER percent staining and intensity (P < 0.05). ER expression was increased in women with ADH and/or those over age 55. ER expression did not significantly impact breast cancer risk in patients diagnosed with atypia. We found increasing ER expression in AH with increasing age. ER expression in AH does not further discriminate breast cancer risk in women with atypia.

show abstract

Section: Discussionmentioning

confidence: 99%

Estrogen Receptor Expression in Atypical Hyperplasia: Lack of Association with Breast Cancer

Barr

Degnim

Hartmann

et al. 2011

Cancer Prevention Research

View full text Add to dashboard Cite

show abstract

“…Antigen retrieval was achieved in 0.001 M citrate buVer (pH = 6.0) at 85°C for 18 h. As far as ERa evaluation is concerned, the percentage of positive cells (nuclei) was analyzed as previously described [21]. In all cases, the area of maximum staining intensity was preselected on each slide and a minimum of 100 cells were evaluated in the designated area.…”

Section: Methodsmentioning

confidence: 99%

Co-expression of bone morphogenetic protein 6 with estrogen receptor a in endometriosis

Athanasios

Afrodite²,

Effstratios³

et al. 2011

Arch Gynecol Obstet

View full text Add to dashboard Cite

The availability of BMP-6 in the ectopic endometrium may be at least partly involved in the mechanisms of attachment, survival and expansion of endometriosis. Moreover, the statistically significant correlation in expression of BMP-6 and ERa demonstrated in this study may be associated with the development of rich in estrogen microenvironment, but requires further investigation. In conclusion, this is the first study in our knowledge demonstrating strong expression of BMP-6 in endometriosis.

show abstract

“…[127], the cells occupy less than half the acini, but do not have the defining features of LCIS, which is characterized by extensive distention and filling of a lobular unit [70,128]. Immunohistochemical (IHC) analysis shows strong ER- α in lobular neoplasia, compared to adjacent normal breast tissue [123]. …”

Section: Molecular Pathology Of Early Breast Lesionsmentioning

confidence: 99%

Biologic characteristics of premalignant breast disease

Cole

Tabernero

Anderson

2011

CBM

View full text Add to dashboard Cite

Breast cancer is the second leading cause of cancer death in women in the United States. While mammography and breast magnetic resonance imaging (MRI) improve detection of early disease, there remains an Ullmet need for biomarkers for risk stratification, early detection, prediction, and disease prognosis. A number of early breast lesions, from atypical hyperplasias to carcinomas in situ, are associated with an increased risk of developing subsequent invasive breast carcinoma. The recent development of genomic, epigenomic, and proteomic tools for tissue biomarker detection, including array CGH, RNA expression microarrays, and proteomic arrays have identified a number of potential biomarkers that both identify patients at increased risk, as well as provided insights into the pathology of early breast cancer development. This chapter focuses on the detection and application of tissue and serum biomarkers for the identification and risk stratification of early breast cancer lesions.

show abstract

Immunohistochemical expression of estrogen receptors alpha and beta in lobular neoplasia

Cited by 8 publications

References 22 publications

Estrogen Receptor Expression in Atypical Hyperplasia: Lack of Association with Breast Cancer

Estrogen Receptor Expression in Atypical Hyperplasia: Lack of Association with Breast Cancer

Co-expression of bone morphogenetic protein 6 with estrogen receptor a in endometriosis

Biologic characteristics of premalignant breast disease

Contact Info

Product

Resources

About