Immunohistochemical expression of latent membrane protein 1 (LMP1) and p53 in nasopharyngeal carcinoma: Moroccan experience

Tabyaoui, Imane; Serhier, Z.; Sahraoui, S.; Sayd, Shermil; Cadi, Rachida; Bennani, O; Benider, A; Zamiati, S.; Tahiri, Jouti N

doi:10.4314/ahs.v13i3.27

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…In the present study, expression of p53 in AM‐BC was detected in all six cases (100%); this expression was higher than that in other histological variants of AM (Florescu et al, ; Kumamoto, Izutsu, et al, ; Kumamoto, Takahashi, et al, ). p53 is undetectable in normal cells, but can be recognized by IHC when it has a longer half‐life due to genetic mutation (Bosch et al, ; Tabyaoui et al, ). In this study, however, mutation analysis of the p53 gene in AM‐BC could not be investigated because of the rarity of the cases; thus, further studies should be performed to determine the association between the poor prognosis of AM‐BC and the expression of p53 .…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic study on a rare variant of ameloblastoma with basal cell features

et al. 2019

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Objectives: To investigate the clinical features, pathologic manifestations, and biologic behaviors of a variant of ameloblastoma with basal cell features (AM-BC). Materials and methods: Following retrospective review of the clinical and pathological data of six cases of AM-BC, we described their histological and immunohistochemical (IHC) features and discussed the biologic behaviors, prognoses, pathogenesis, and clinical relevance of AM-BC. Direct sequencing of polymerase chain reaction products was also performed in all cases. Results: The six cases of AM-BC involved four women and two men, aged 22-82 years. Four lesions occurred in the maxilla and two in the mandible. Histologically, the basal cells tended to be arranged as unequally sized follicles, strands, or cords of odontogenic epithelium in the connective tissue stroma. Little or no stellate reticulum was present in the central portion of the nest. Expression of CKs was consistent with other histological variants of ameloblastoma (AM), but AM-BC had significantly higher p53 and Ki-67 (p < 0.05) labeling indices than other histological variants of AM. Two patients had BRAF gene mutations.

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Section: Discussionmentioning

confidence: 99%

Clinicopathologic study on a rare variant of ameloblastoma with basal cell features

et al. 2019

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“…We're always observing in North Tunisia a bimodal distribution characterized by 2 peaks at 15 -20 years old and a second at 50 years old, previously reported in several intermediate-risk populations in Northern Africa (Tabyaoui et al, 2013) and Western Asia (Andejani et al, 2004;Barista et al, 2007;Tsao et al, 2014;). The bimodality of disease rates, suggests the possibility of distinct causal entities.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Carcinoma Incidence in North Tunisia: Negative Trends in Adults but not Adolescents, 1994-2006

Wided¹,

Boussen²,

Hsaïri³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Nasopharyngeal carcinoma (NPC) is the second most common neoplasm of head and neck in Tunisia. The distribution is bimodal with a first period occurrence between 15 and 20 years old and a second peak at around 50 years of age. Undifferentiated carcinoma of nasopharynx type III (UCNT) is the predominant histological type (93.4%). Data of cancer registry of North Tunisia confirmed that it is an intermediate risk area for NPC with overall ASRs of 3.6 and 1.6/100,000 respectively in males and females. This study aimed to present the evolution of incidence rate of nasopharyngeal carcinoma over a period of 12 years (1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006). Data of cancer registry of North Tunisia (NTCR), covering half of the Tunisian population, were used to determine evolution of NPC incidence, calculated by 5 year periods. The estimated annual percentage change (EAPC) was used as an estimate of the trend. To best summarize the behavior or the data trend across years, we used a join-point regression program. Between 1994 and 2006, we observed negative annual average change of standardized incidence in men and women (-3.3%and -2.7%) also for the standardized incidences which showed a rather important decline (26.4% in males and 22.3% in females). The truncated age standardized incidence rate of NPC in adults aged of 30 years old and more (N= 1209) decreased by -0.4% per year from 1994 to 2006 over time in north Tunisia dropping from 6.09 to 4.14 person-years. However, the rate was relatively stable during this period among youths aged 0-29 years (N= 233) in both sexes. NPC demonstrated a favorable evolution from 1994-2006 probably due to a improvement in socioeconomic conditions.

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“…They suggested that LMP-1 protein expression may be associate with poorer prognosis in NPC patients [23]. Tabyaoui et al in their study did not detect any overexpression of LMP-1 protein in NPC patients [24].…”

Section: Discussionmentioning

confidence: 86%

Latent Membrane Protein-1 Protein Induction toward Vascular Endothelial Growth Factor Expression in the Development of Nasopharyngeal Carcinoma

Chrestella

Farhat

Daulay

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Nasopharyngeal carcinoma (NPC) is associated with Epstein–Barr virus infection as the main factor. Latent membrane protein (LMP)-1 protein and vascular endothelial growth factor (VEGF) have been suggested as the prognostic biomarker for NPC. AIM: This study is conducted to analyze the overexpression of LMP-1 protein and VEGF and the combination of these two in NPC patients. The role of LMP-1 protein in the induction of VEGF is identified by analyzing the association between these two proteins. METHODS: A cross-sectional design study is conducted at Adam Malik General Hospital. Formalin-fixed, paraffin-embedded sections from the NPC tissue samples are submitted for immunohistochemistry staining. Fisher’s exact test is used to analyze variables relation. RESULTS: Among 56 samples, there was a significant correlation between LMP-1 protein overexpression with histopathological type and clinical staging, and VEGF overexpression with lymph node enlargement and clinical staging (p < 0.05). There was no significant correlation between LMP-1 protein with VEGF in NPC patients (p > 0.05). CONCLUSION: Increased expressions of LMP-1 protein, VEGF, and a combination of LMP-1 protein and VEGF are noted in correlation with increasing the clinical stages. In contrast to the previously suggested hypotheses, the correlation between these two proteins is not significant in the present study. It could happen due to the different associations of each protein overexpression toward the clinical parameter. However, these two proteins could be used in evaluating the prognosis and providing a targeted therapy to NPC.

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Immunohistochemical expression of latent membrane protein 1 (LMP1) and p53 in nasopharyngeal carcinoma: Moroccan experience

Cited by 10 publications

References 28 publications

Clinicopathologic study on a rare variant of ameloblastoma with basal cell features

Clinicopathologic study on a rare variant of ameloblastoma with basal cell features

Nasopharyngeal Carcinoma Incidence in North Tunisia: Negative Trends in Adults but not Adolescents, 1994-2006

Latent Membrane Protein-1 Protein Induction toward Vascular Endothelial Growth Factor Expression in the Development of Nasopharyngeal Carcinoma

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