Immunohistochemical expression of MUC1 in different grades of oral squamous cell carcinoma

Shobhita, K. C.; Shyam, Ndvn; Preethi, P.; Poornima, R; Priyanka, M.; Shravani, R.

doi:10.21276/apjhs.2018.5.2.31

Cited by 7 publications

(5 citation statements)

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“…These observations let us know that the carcinoma with an active proliferation were only showing positivity for MUC1. Also, are in similar with the results obtained in the study by Shobitha et al, 20 Kumar MH et al 18 and Nitta et al 12 The cytoplasmic and membranous staining of MUC1 in the squamous epithelial cells may be associated to its cytoplasmic and transmembrane subunits respectively.…”

Section: Normal Cellssupporting

confidence: 90%

“…The other tissue samples which can be taken up as positive control for mucin 1 are gastrointestinal carcinoma, salivary ductal tissue, urothelial carcinoma, lung carcinoma, 10 breast carcinoma and salivary gland carcinoma tissues. These are according to studies conducted by Suguru yonezawa et al, 11 Nitti et al, 12 Xialong et al, 13 Zhonghua et al, 14 Farzana Mahomed et al, 15 Sukhwinder et al, 16 Guosheng et al, 17 M. Harishkumar et al, 18 Arush Thakur et al 19 and KC Shobhita et al 20 The localization of this transmembrane glycoprotein is interpreted as brown coloured cytoplasmic and membranous staining which were regarded positive for MUC1. Similar MUC1 staining pattern was observed in most of the studies done by Nitti et al, 12 Suguru Yonezawa et al, 11 Xialong et al, 13 Zhonghua et al, 14 Farzana Mahomed et al, 15 Sukhwinder et al, 16 Guosheng et al, 17 M. Harishkumar et al, 18 Arush Thakur et al 19 and KC Shobhita et al 20 Whereas according to Sandra J Gendler et al, 10 the brown coloured cytoplasmic mucin component alone was considered positive for MUC1.…”

Section: Discussionmentioning

confidence: 95%

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Mucin1 utterance in oral squamous cell carcinoma: A cancer maker and target for nanotheranostics

Kootiswaran S,

Balamurali,

Ramesh

et al. 2023

JOOO

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Mucins are cell bound high molecular weight glycoproteins which are secreted by epithelial cells. Total 21 mucin variants are identified till date. Mucin1 (MUC1) is a transmembrane glycoprotein, which when reacts with beta-catenin, can able to enter the nucleus to activate T-cell factor/leukocyte enhancing factor 1 transcription factors and gene expression, after which it may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, leading to tumor progression.To compare and correlate the expression and positive intensity of MUC1 in oral squamous cell carcinoma, oral epithelial dysplasia and normal oral mucosa using Immunohistochemistry. This study included a total of 45 cases in which the study groups are oral squamous cell carcinoma (n=15), oral epithelial dysplasia (n=15) and control of normal oral mucosa (n=15), which are analysed for the expression of anti MUC1 rabbit monoclonal antibody using immunohistochemical technique.The mucin1 positive cells in the study groups were as follows, 53.3% cases in OSCC, 13.3% cases in OED and none showed positivity in normal oral mucosa. The results obtained were statistically analysed using Kruskal-Wallis test and there was a statistically significant difference in score between the different tissue groups, Kruskal – Wallis H score = 13.034, p = 0.001.There is progressive increase in the MUC1 expression from oral epithelial dysplasia to OSCC. This utterance might be due to suppression of inhibitory proteins for MUC1 immunoexpression in mature atypical squamous cells as well as proposed to act both as an anti-adhesive and adhesive molecule.

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Section: Normal Cellssupporting

confidence: 90%

Section: Discussionmentioning

confidence: 95%

Mucin1 utterance in oral squamous cell carcinoma: A cancer maker and target for nanotheranostics

Kootiswaran S,

Balamurali,

Ramesh

et al. 2023

JOOO

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“…One physical property of MUC1, i.e. the presence of sialic acid on the terminal carbohydrate structure, might be more important in determining the extent of metastasis, as sialylation of this part of the cell surface imparts a strong negative charge that affects invasion and metastasis (Shobhita et al, 2018).…”

Section: Oral Precancer and Cancermentioning

confidence: 99%

Regulation of mucin 1 expression and its relationship with oral diseases

Kashyap

Kullaa

2020

Archives of Oral Biology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…2F, G). A progressive increase in MUC1 expression from WDSCC to PDSCC might be due to aberrant glycosylation that occurs in increasing stages of OSCC, resulting in the shortening of the carbohydrate units and exposing more obscure antigens of peptide, and the carbohydrate composition of MUC1 makes it tumor speci c [15,21]. Donald et al also proved that MUC4 production may be a more biologically useful marker of the degree of differentiation [5].…”

Section: Discussionmentioning

confidence: 99%

Quantitative Proteogenomic Characterization In MUC1 And MUC4 In Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, And Normal Oral Mucosa In Carcinogenesis

John,

Sharma,

Chandra

et al. 2024

Preprint

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Context: Mucins are glycoproteins with a significant molecular weight that have a diverse range of biological functions. MUC1 & MUC4 are transmembrane mucin family members that are expressed in airway epithelial cells and body fluids. It is expressed excessively in numerous carcinomas in addition to their altered expression. A thorough review of the literature reveals very limited research about MUC1 & 4 expressions in oral malignancies and oral premalignant disorders. Aim: To assess the pattern and quantity of gene expression in MUC1 & MUC4 individually in various grades of oral squamous cell carcinoma (OSCC), oral premalignant disorders (OPMDs)- oral epithelial dysplasia (OED), oral submucous fibrosis (OSF), oral lichen planus (OLP), and compared with normal oral mucosa (NOM). Materials and Methods: Immunohistochemistry and qRTPCR evaluation of MUC1 & 4 on sixty-three cases of OSCC, OPMD, and NOM was accomplished. Statistical analysis: The one-way ANOVA test and Chi-square test were done for statistical analysis. Results: The overall immunoexpression of MUC1 & 4 increased significantly from NOM to OPMDs to OSCC. In the subgrades of OSCC and OPMDs, the staining intensity varied. For MUC4, the intensity was strongest in well-differentiated grades and MUC1, exhibiting a higher expression in poorly differentiated grades of OSCC and OPMDs. Conclusion: The study's results indicate that MUC1 & 4 individually are crucial for monitoring OSCC and OPMD pathogenesis as the former gives an idea of highly undifferentiated grades while the latter indicated more differentiated tumors and perhaps a better prognosis. Therefore, the two can be useful tumor markers for determining the severity and eliminating it in its early phases

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Immunohistochemical expression of MUC1 in different grades of oral squamous cell carcinoma

Cited by 7 publications

References 0 publications

Mucin1 utterance in oral squamous cell carcinoma: A cancer maker and target for nanotheranostics

Mucin1 utterance in oral squamous cell carcinoma: A cancer maker and target for nanotheranostics

Regulation of mucin 1 expression and its relationship with oral diseases

Quantitative Proteogenomic Characterization In MUC1 And MUC4 In Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, And Normal Oral Mucosa In Carcinogenesis

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