Immunohistochemical expression of p53 and c-Myc at the invasive front of oral squamous cell carcinoma and its relation with clinicopathologic characteristics

Rai, Pragati; Acharya, Swetha; Tayaar, Amsavardani S.; Kale, Jyoti; Hallikeri, Kaverı

doi:10.1016/j.anndiagpath.2017.05.011

Cited by 1 publication

(2 citation statements)

References 37 publications

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“…[ 2 ] Almost all cancers are preceded by the development of a precancerous lesion, which then progresses to cancer at a later stage . [ 13 ]…”

Section: Discussionmentioning

confidence: 99%

“…Three potential explanations for this could have been: the absence of mutation, meaning the wild type p53 protein was undetected due to its short half-life; the mutation not resulting in protein stabilization; or the p53 gene being undetectable. [ 13 ] Depending on the cellular responses and kind of cell, p53 activation can cause several reactions. For instance, DNA damage may result in apoptosis or growth arrest, both of which aim to stop damaged cells from procreating and transferring mutations to the following generation.…”

Section: Discussionmentioning

confidence: 99%

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Pathogenetic model of survivin-dependent molecular signalling pathways in tumorigenesis of oral cancer and precursor lesions

Aggarwal,

Shetty,

Jain

et al. 2023

Journal of Oral and Maxillofacial Pathology

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Background: p53 tumour suppressor gene limits unchecked cellular growth in response to DNA damage, by causing G1 arrest and the activation of apoptosis. Inhibitors of apoptosis include survivin which acts by inhibition of caspases. Survivin has a significant role as a cell cycle modulator and is only minimally present in mature tissues. Aberrant expression of p53 and survivin has been evaluated in various carcinomas. Thus, the objective of this research was to elucidate the co-expression of p53 and survivin in tissue samples of Oral Potentially Malignant Disorders (OPMDs) and Oral Squamous Cell Carcinoma (OSCCs). Method: Thirty tissue samples of OPMDs and 30 tissue samples of OSCCs taken from department archives were used in the study. Expression of p53 and survivin was analyzed in the study groups by the help of immunohistochemistry. Also, co-expression of both the markers was evaluated. Results: The expression of p53 and survivin in the oral epithelium of patients with OSCCs was significantly higher than that in patients with OPMDs (P value ≤0.05). Conclusion: Our results provide insights into the altered survivin and p53 co-expression with significant immunoexpression within the study groups. Therefore, survivin and p53 could be better markers for identifying cell proliferation and apoptotic pathway. Also, malignant transformation rate of OPMD increases with increased expression of these markers.

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“…[ 2 ] Almost all cancers are preceded by the development of a precancerous lesion, which then progresses to cancer at a later stage . [ 13 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pathogenetic model of survivin-dependent molecular signalling pathways in tumorigenesis of oral cancer and precursor lesions

Aggarwal,

Shetty,

Jain

et al. 2023

Journal of Oral and Maxillofacial Pathology

View full text Add to dashboard Cite

show abstract

Immunohistochemical expression of p53 and c-Myc at the invasive front of oral squamous cell carcinoma and its relation with clinicopathologic characteristics

Cited by 1 publication

References 37 publications

Pathogenetic model of survivin-dependent molecular signalling pathways in tumorigenesis of oral cancer and precursor lesions

Pathogenetic model of survivin-dependent molecular signalling pathways in tumorigenesis of oral cancer and precursor lesions

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