Immunohistochemical expression of vascular endothelial growth factor in orofacial lesions – A review

Gupta, Bhavana; Chandra, Shaleen; Raj, Vineet; Gupta, V.

doi:10.1016/j.jobcr.2016.01.006

Cited by 7 publications

(7 citation statements)

References 35 publications

(20 reference statements)

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“…При возникновении посттатуажной гранулемы красной каймы губ (ГККГ) в верхнем и среднем слоях дермы образуется плотный инфильтрат из гистиоцитов (макрофагов), антигенпрезентирующих клеток Лангерганса и периваскулярных лимфоцитов [7,8]. Все перечисленные клетки обладают способностью экспрессировать сигнальные провоспалительные и ангиогенные молекулы, прежде всего фактор роста сосудистого эндотелия (ФРСЭ) [9]. Патогенетическое лечение ГККГ должно быть направлено на элиминацию фрагментов красного пигмента из очага гранулемы и подавление воспаления путем ремоделирования микрососудистого русла дермы, ассоциированного с областью ГККГ.…”

Section: актуальностьunclassified

Copper vapor laser treatment of granuloma of the vermilion border of the lips arising as a complication after permanent make-up

Ponomarev

Владимирович²,

Andrusenko³

et al. 2021

Vestnik dermatologii i venerologii

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Background. Granulomas of the vermilion border of the lips (GVBL); as a complication of lip tattooing; inevitably poses cosmetic problems. Surgical excision and cryodestruction are associated with an increased risk of scarring and recurrence of GVBL. Laser therapy can selectively destroy a pigment and achieve the desired cosmetic result with minimal risk of side effects. So laser treatment was reported to be a more relevant method of treatment of GVBL. Aim. To evaluate the effectiveness of treatment of GVBL with copper vapor laser (CVL) radiation. Case report. 39-year-old female patient; without manifestations of systemic sarcoidosis; reported a 2-year history of granulomas of the lips vermilion border. She had a permanent makeup cosmetic tattoo before the onset of granulomas after lip tattooing. Histopathological examination revealed the presence of pigment in the upper and middle layers of the dermis. GVBL treatment was performed using a CVL during a single procedure; with an average CVL power of 0.60.8 W; with a ratio of 3:2 at wavelengths of 511 nm and 578 nm; exposure time 0.3 s. Light spot diameter 1 mm. CVL treatment led to a pronounced elimination of all GVBL without side effects within five years. Discussion. CVL allows a combined mode of exposure; consisting of grinding large granules of pigment to sizes that can be absorbed by the lymphatic system and suppressing VEGF expression using radiation with a wavelength of 578 nm. Conclusions. The CVL treatment provided an excellent cosmetic result due to selective photodestruction of the pigment and complete remodeling of the vascular bed associated with GVBL. The high clinical efficiency of eliminating post-tattooing foci of GVBL using CVL without side effects allows us to suggest this method for dermatologists and cosmetologists as a highly effective and inexpensive way to eliminate complications of permanent makeup.

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Section: актуальностьunclassified

Copper vapor laser treatment of granuloma of the vermilion border of the lips arising as a complication after permanent make-up

Ponomarev

Владимирович²,

Andrusenko³

et al. 2021

Vestnik dermatologii i venerologii

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“…Vascular endothelial growth factors (VEGFs) are vital regulators of angiogenesis and vasculogenesis that are expressed in response to soluble mediators, such as cytokines and growth factors [ 1 ]. The physiologic functions of the VEGF signaling axis involve blood vessel formation-endothelial cell proliferation, migration, and cell survival-, regulation of vascular permeability and maintenance of bone homeostasis and repair, affecting the differentiation and function of osteoblasts and osteoclasts [ 2 ]. VEGF is also required for stem cell and monocyte/macrophage recruitment, maintenance of tissue barrier functions and neuroprotection [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The VEGF family includes VEGF-A, -B, -C and -D, as well as placental growth factor, which interact differently with cell-surface tyrosine kinase receptors, VEGFR 1–3. Overall, they regulate blood vessel morphogenesis and permeability, though VEGF-C and VEGF-D are primarily implicated in regulation of lymphogenesis [ 2 ]. As the prototypical VEGF, VEGF-A is considered the most potent stimulator of vasculogenesis and angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, the coordinated output from these signaling systems controls angiogenesis, blood flow, tissue perfusion, inflammatory cell extravasation, and bone remodeling and repair [ 2 , 3 ]. Herein, we aim to explore the role of VEGF signaling in oral cancer and destructive periodontal inflammatory diseases, with emphasis in its translational applications as potential biomarkers and therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

“…Hypoxia inducible factor (HIF) is a pivotal transcription factor induced under hypoxia that transactivates target genes, including VEGF, and has a direct effect on the master switch of inflammation, nuclear factor (NF)-κB pathway. Accordingly, the coordinated output from these signaling systems controls angiogenesis, blood flow, tissue perfusion, inflammatory cell extravasation, and bone remodeling and repair [2,3]. Herein, we aim to explore the role of VEGF signaling in oral cancer and destructive periodontal inflammatory diseases, with emphasis in its translational applications as potential biomarkers and therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases

et al. 2021

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Vascular endothelial growth factors (VEGFs) are vital regulators of angiogenesis that are expressed in response to soluble mediators, such as cytokines and growth factors. Their physiologic functions include blood vessel formation, regulation of vascular permeability, stem cell and monocyte/macrophage recruitment and maintenance of bone homeostasis and repair. In addition, angiogenesis plays a pivotal role in chronic pathologic conditions, such as tumorigenesis, inflammatory immune diseases and bone loss. According to their prevalence, morbidity and mortality, inflammatory diseases affecting periodontal tissues and oral cancer are relevant non-communicable diseases. Whereas oral squamous cell carcinoma (OSCC) is considered one of the most common cancers worldwide, destructive inflammatory periodontal diseases, on the other hand, are amongst the most prevalent chronic inflammatory conditions affecting humans and also represent the main cause of tooth loss in adults. In the recent years, while knowledge regarding the role of VEGF signaling in common oral diseases is expanding, new potential translational applications emerge. In the present narrative review we aim to explore the role of VEGF signaling in oral cancer and destructive periodontal inflammatory diseases, with emphasis in its translational applications as potential biomarkers and therapeutic targets.

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Correlation of VEGF and MMP-2 levels in oral lichen planus: An in vivo immunohistochemical study

Hazzaa

Shiekh

Abdelgawad

et al. 2020

Journal of Oral Biology and Craniofacial Research

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Immunohistochemical expression of vascular endothelial growth factor in orofacial lesions – A review

Cited by 7 publications

References 35 publications

Copper vapor laser treatment of granuloma of the vermilion border of the lips arising as a complication after permanent make-up

Copper vapor laser treatment of granuloma of the vermilion border of the lips arising as a complication after permanent make-up

Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases

Correlation of VEGF and MMP-2 levels in oral lichen planus: An in vivo immunohistochemical study

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