2018
DOI: 10.1007/s10517-018-3995-z
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Immunohistochemical Features of O6-Methylguanine-DNA Methyltransferase Expression during Ovarian Endometriosis

Abstract: A comparative immunohistochemical study for the expression of O6-methylguanine-DNA methyltransferase (MGMT) was performed in tissues of the eutopic endometrium and ovarian endometriosis. The highest level of MGMT expression in eutopic endometrial tissue was observed in epitheliocyte nuclei during the proliferative phase. In regions of endometriosis the expression of MGMT in epitheliocyte nuclei was shown to increase during stages I and II, but decreased in stages III and IV. The progression of endometriosis wa… Show more

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Cited by 1 publication
(3 citation statements)
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“…S5 ). Notably, it has been reported that TPM2 , HOXB2 , and MGMT are associated with EM [37] , [38] , [39] . Based on our comprehensive integrative genomics analysis, we identified 14 genes, including 11 novel risk genes implicated in EM susceptibility ( Table 1 ).…”
Section: Resultsmentioning
confidence: 99%
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“…S5 ). Notably, it has been reported that TPM2 , HOXB2 , and MGMT are associated with EM [37] , [38] , [39] . Based on our comprehensive integrative genomics analysis, we identified 14 genes, including 11 novel risk genes implicated in EM susceptibility ( Table 1 ).…”
Section: Resultsmentioning
confidence: 99%
“…To give an overview of significant loci obtained through GWAS, we summarized these reported significant variants in the Supplementary Table S10 . Among the 14 identified genes, TPM2 , HOXB2 , and MGMT have been shown to be associated with EM in a few previous studies [37] , [38] , [39] . Specifically, TPM2 encodes beta-tropomyosin, which plays a role in muscle contraction and motility, and helps maintain cell shape and cell-matrix interactions.…”
Section: Discussionmentioning
confidence: 97%
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