Immunohistochemical investigation of epidermal growth factor receptor expression in ameloblastomas

Abstract

Immunohistochemical analysis was performed to determine the localization of epidermal growth factor receptor (EGFR) in ameloblastomas. Ameloblastoma samples were classified into follicular, plexiform, and basal cell types. The number of cases in each category was 17, 19 and 3, respectively. Ameloblastomas, disregarding their histological type, consist of two cell forms: peripheral columnar cells and central stellate cells. The frequency of EGFR expression was much higher in the latter than in the former (P < 0.005). On analysis with respect to histological types, the frequency of EGFR expression in columnar cells was not significantly different between the follicular and the plexiform types, but was observed more frequently in the stellate cells in the follicular than in the plexiform ameloblastomas (P < 0.05). This pattern of EGFR expression was not consistent with the PCNA staining pattern, but was similar to that of keratin expression which we have reported previously. The present study suggests that EGFR expression in ameloblastomas is closely associated with tumour differentiation, and squamous differentiation in particular.

EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence

“…However, Li et al [29] reported that EGFR was detected in all six of their cases of ameloblastoma. Ueno et al, [30] examined 39 cases of solid ameloblastoma and EGFR expression was found in 30 (88%). Vered et al, [19] reported that all specimens were EGFR-positive using membranous, or both membranous and cytoplasmic staining as positivity criteria.…”

Immunoexpression of transforming growth factor β in desmoplastic ameloblastoma

“…In comparison with the ordinary ameloblastoma [7,15,16,17,26,30,32,35], there have been only a few studies on the immunoprofile of various proteins in DA. Siar and Ng [28] described differences in the expression of some antigens such as keratin and vimentin between DA and ordinary ameloblastomas.…”

Yumuşak dokunun nadir görülen tümörlerinde ve odontojenik tümörlerde immünohistokimyasal yöntem ve floresan in situ hibridizasyonla epidermal growth faktör reseptör varlığının gösterilmesi

“…EGFR expression has been demonstrated in ameloblastomas in some studies [23][24][25][26][27][28] . Among epithelial odontogenic tumors, ameloblastoma is the one which shows strong EGFR expression 29 .…”