Immunohistochemical Investigation of Metastasis-Related Chemokines in Deep-Infiltrating Endometriosis and Compromised Pelvic Sentinel Lymph Nodes

Borrelli, Giuliano Moysés; Abrão, Maurício Simões; Taube, Eliane Tabea; Darb‐Esfahani, Silvia; Köhler, C.; Kaufmann, Andreas M.; Chiàntera, Vito; Mechsner, Sylvia

doi:10.1177/1933719115592711

Cited by 14 publications

(10 citation statements)

References 44 publications

(68 reference statements)

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“…The lymphatic spread of endometriosis, connected to the hyper expression of two chemokine receptors, also involved in the process of metastasis in cancer, CCR7 and CXCR4 [33] could hypothetically create a microembolus, able to obstruct the course of the lymphatic flow. However, at the moment, these are only hypotheses.…”

Section: Discussionmentioning

confidence: 99%

Sentinel Lymph Node Biopsy in the Treatment of Endometrial Cancer: Why We Fail? Results of a Prospective Multicenter Study on the Factors Associated with Failure of Node Mapping with Indocyanine Green

Ianieri

Puppo²,

Novelli³

et al. 2019

Gynecol Obstet Invest

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Background: The sentinel lymph node (SLN) mapping for endometrial cancer staging is gaining wide diffusion, but there is no definitive evidence on the factors associated with the failure of mapping. Objectives: To analyze the factors associated with the possible failure of bilateral SLN mapping with indocyanine green (ICG). Methods: A prospective observational study without control on 110 patients with endometrial cancer apparently confined to the uterus, underwent laparoscopic surgical staging with SLN mapping with ICG. Results: Possible risk factors associated with bilateral mapping failure were analyzed, and a multivariate analysis was performed. The bilateral detection rate for SLNs mapping was 72.7%, whereas at least one SLN was detected in 79.1% of patients. No SLNs were identified in 6.3%. None of the patients or features related to tumor were associated with a risk of failure of the method. The only factor analyzed that was significantly associated with the success of bilateral mapping was the surgeon (p = 0.003). Conclusions: Neither obesity nor the presence of lymph node metastases was associated with mapping failure. However, there remains a need for further studies to understand all the mechanisms linked to the unsuccessful method results and to reduce the use of systematic lymphadenectomy in the case of mapping failure.

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Section: Discussionmentioning

confidence: 99%

Sentinel Lymph Node Biopsy in the Treatment of Endometrial Cancer: Why We Fail? Results of a Prospective Multicenter Study on the Factors Associated with Failure of Node Mapping with Indocyanine Green

Ianieri

Puppo²,

Novelli³

et al. 2019

Gynecol Obstet Invest

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“…Although endometriosis is a benign, estrogen‐dependent disease, endometriotic cells share some features with cancer cells, such as invasiveness and the potential to metastasize . Therefore, the establishment and development of endometriosis is thought to share several mechanisms, including epithelial‐mesenchymal transition (EMT), with malignant disorders .…”

Section: Introductionmentioning

confidence: 99%

ZEB1 expression is a potential indicator of invasive endometriosis

Furuya

Masuda

Hara³

et al. 2017

Acta Obstet Gynecol Scand

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This is the first observation of ZEB1 expression in epithelial cells of benign disease. The preferential expression of ZEB1 in epithelial cells of endometriotic lesions suggests that these cells may have, at least in part, a higher level of mesenchymal features possibly via ZEB1-driven epithelial-mesenchymal transition than normal endometria and that ZEB1 can be a potential indicator of invasiveness or severity of endometriosis.

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“…However, the mechanism of EMS is unclear, the reflux theory of menstruation is most widely accepted. It is suggested that invasion and metastasis is a very important step in flowing endometrial tissue ( Borrelli et al, 2015 ; Chui et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-endometriosis Mechanism of Jiawei Foshou San Based on Network Pharmacology

et al. 2018

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Jiawei Foshou San (JFS) is the new formula originated from classic Foshou San formula, composed with ligustrazine, ferulic acid, and tetrahydropalmatine. Previously JFS inhibited the growth of endometriosis (EMS) with unclear mechanism, especially in metastasis, invasion, and epithelial–mesenchymal transition. In this study, network pharmacology was performed to explore potential mechanism of JFS on EMS. Through compound–compound target and compound target–EMS target networks, key targets were analyzed for pathway enrichment. MMP–TIMP were uncovered as one cluster of the core targets. Furthermore, autologous transplantation of EMS rat’s model were used to evaluate in vivo effect of JFS on invasion, metastasis and epithelial–mesenchymal transition. JFS significantly suppressed the growth, and reduced the volume of ectopic endometrium, with modification of pathologic structure. In-depth study, invasion and metastasis were restrained after treating with JFS through decreasing MMP-2 and MMP-9, increasing TIMP-1. Meanwhile, JFS promoted E-cadherin, and attenuated N-cadherin, Vimentin, Snail, Slug, ZEB1, ZEB2, Twist. In brief, anti-EMS effect of JFS might be related to the regulation of epithelial–mesenchymal transformation, thereby inhibition of invasion and metastasis. These findings reveal the potential mechanism of JFS on EMS and the benefit for further evaluation.

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Immunohistochemical Investigation of Metastasis-Related Chemokines in Deep-Infiltrating Endometriosis and Compromised Pelvic Sentinel Lymph Nodes

Cited by 14 publications

References 44 publications

Sentinel Lymph Node Biopsy in the Treatment of Endometrial Cancer: Why We Fail? Results of a Prospective Multicenter Study on the Factors Associated with Failure of Node Mapping with Indocyanine Green

Sentinel Lymph Node Biopsy in the Treatment of Endometrial Cancer: Why We Fail? Results of a Prospective Multicenter Study on the Factors Associated with Failure of Node Mapping with Indocyanine Green

ZEB1 expression is a potential indicator of invasive endometriosis

Anti-endometriosis Mechanism of Jiawei Foshou San Based on Network Pharmacology

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