Immunohistochemical Localisation of Alpha-Fetoprotein (AFP) in Germ Cell Tumours: Evidence for AFP Production by Tissues Different from Endodermal Sinus Tumour

Wagener, Christian; Menzel, B; Breuer, H; Weißbach, L.; Tschubel, K; Henkel, K.; Gedigk, P.

doi:10.1159/000225557

Cited by 23 publications

(4 citation statements)

References 6 publications

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“…AFP is produced by yolk sac tumor components and undifferentiated embryonal carcinoma cells, (26) as well as by immature or mature teratoma (27). HCG staining is present in choriocarcinoma and syncytiotrophoblastic giant cells (26), but also in undifferentiated mononuclear embryonal carcinoma cells (9).…”

Section: Discussionmentioning

confidence: 99%

Importance of a new tumor market TRA-1-60 in the follow-up of patients with clinical stage I nonseminomatous testicular germ cell tumors

Gels

Marrink

Visser

et al. 1997

Annals of Surgical Oncology

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Section: Discussionmentioning

confidence: 99%

Importance of a new tumor market TRA-1-60 in the follow-up of patients with clinical stage I nonseminomatous testicular germ cell tumors

Gels

Marrink

Visser

et al. 1997

Annals of Surgical Oncology

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“…The latter finding is difficult to understand because yolk sac cells or derived cell clones are the only producers of AFP in testicular carcinoma to date. Comparable prob lems in evaluating AFP-positive immunohistology in nonseminoma patients were observed by Wagner et al [ 15], who finally stated a relationship between entodermal structure and AFP synthesis. This fact is not suffi cient to explain AFP synthesis in mature teratoma of the testis.…”

Section: Nonseminoma Germinal Tumorsmentioning

confidence: 88%

Quantification of Alpha-Fetoprotein and Beta-HCG in Testis Tumor Patients

Dunzendorfer¹,

Jurincic²

1987

Urol Int

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Patients with testis tumor were investigated for serum and tissue levels of alpha-fetoprotein and beta-human chorionic gonadotropin (beta-HCG). The tissue immune peroxidase-antiperoxidase staining for the tumor marker was quantitated by computer-assisted immunohistophotometry and immuno-gamma ray histospectrometry. The results supported the general view that mostly polynuclear giant cells produce beta-HCG in 66 % of nonseminoma cancer. This finding qualifies beta-HCG as relatively unspecific in the absence of chorioepithelial cells in the tumor. Discrepancies of tissue and serum beta-HCG values may be caused by deglycolysation of beta-HCG while penetrating the perivascular tissues. Alpha-fetoprotein (AFP) appears helpfully to discriminate the true seminoma cancer, which is constantly negative. Histologically pure seminoma which reacts for AFP therefore suggests sclerotic teratoma compartments. A constant finding is the significantly reduced synthesis rate of tumor markers in metastasis compared to primary tumor.

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“…However, several studies demonstrated that immature teratomas without the yolk sac component could produce AFP (27'28). Wagener et al stated that the source of production was the cylindrical cells forming the epithelium of nonspecific glandular structures within the tumor (27). However, in the report by Burrus et al, evidence for AFP production was found in a wide variety of cells of both endodermal and ectodermal origin (28).…”

Section: Discussionmentioning

confidence: 99%

Pure malignant immature teratoma of the ovary: the role of chemotherapy and second-look surgery

Culine¹,

Lhommé²,

Kattan³

et al. 1995

Int J Gynecol Cancer

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Fifteen patients with pure malignant immature teratoma of the ovary were treated at the Institut Gustave Roussy over a 17-year period. Chemotherapy was delivered as primary postoperative therapy in 11 patients. Four other patients received chemotherapy as part of their salvage treatment for recurrent disease. A second-look laparotomy was performed in eight patients. Histological findings were: no tumor in three patients, mature teratoma in four patients, and immature grade 1 teratoma in one patient. The latter five patients had persistent radiologic abnormalities at the end of chemotherapy. Twelve patients remain free of disease 24-228 months from initiation of chemotherapy. Two children were delivered from the two patients who attempted pregnancy. All three patients who died of progressive disease had a grade 3 immature teratoma. We conclude that the treatment of pure immature teratoma of the ovary should include primary conservative surgery and cisplatin-based chemotherapy. Second-look surgery is mandatory in patients with persistant radiologic abnormalities at the completion of chemotherapy.

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Immunohistochemical Localisation of Alpha-Fetoprotein (AFP) in Germ Cell Tumours: Evidence for AFP Production by Tissues Different from Endodermal Sinus Tumour

Cited by 23 publications

References 6 publications

Importance of a new tumor market TRA-1-60 in the follow-up of patients with clinical stage I nonseminomatous testicular germ cell tumors

Importance of a new tumor market TRA-1-60 in the follow-up of patients with clinical stage I nonseminomatous testicular germ cell tumors

Quantification of Alpha-Fetoprotein and Beta-HCG in Testis Tumor Patients

Pure malignant immature teratoma of the ovary: the role of chemotherapy and second-look surgery

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