Immunohistochemical localization and biological activity of 3β-hydroxysteroid dehydrogenase and 5α-reductase in the brain of the frog, Rana esculenta, during development

Sex differences and endocrine regulation of auditory-evoked, neural responses in African clawed frogs (Xenopus)

“…The differences between intact and OVX female X. laevis described here support this idea. While there is ample evidence for androgen synthesis within the brains of male and female frogs (Mensah-Nyagan et al 1996; Bruzzone et al 2010; Vaudry et al 2011), in Xenopus our results suggest instead that circulating ovarian hormones generate the female auditory matched filter.…”

How to contribute to the progress of neuroendocrinology: New insights from discovering novel neuropeptides and neurosteroids regulating pituitary and brain functions

“…The formation of neurosteroids in the brain was originally demonstrated in mammals by the group of Baulieu 30 years ago (Compagnone et al, 1995;Corpéchot et al, 1981Corpéchot et al, , 1983Jo et al, 1989;Lanthier and Patwardhan, 1986;Mathur et al, 1993;Mellon and Deschepper, 1993;Robel and Baulieu, 1985;Robel et al, 1987). De novo synthesis and biological actions of neurosteroids in the brain of other vertebrates have also been established by my group and the groups of Vaudry, Schlinger, Kah, and others (in birds: Freking et al, 2000;London and Schlinger, 2007;London et al, 2003London et al, , 2006London et al, , 2010Matsunaga et al, 2001Matsunaga et al, , 2002Schlinger et al, 1999;Soma et al, 2004;Tam and Schlinger, 2007;Tsutsui and Schlinger, 2001;Tsutsui and Yamazaki, 1995;Tsutsui et al, 1997Tsutsui et al, , 1999Tsutsui et al, , 2003Ukena et al, 1999Ukena et al, , 2001Usui et al, 1995;Vanson et al, 1996;in amphibians: Beaujean et al, 1999;Bruzzone et al, 2010;Do-Rego et al, 2007;Inai et al, 2003;Matsunaga et al, 2004b;Mensah-Nyagan et al, 1994, 1996a, 1996bTakase et al, 1999Takase et al, , 2002…”

Cytochrome P450 17α-hydroxylase/C(17,20)-lyase immunoreactivity and molecular expression in the cerebellar nuclei of adult male rats

“…Using biochemical, molecular, and immunohistochemical approaches, several studies have documented neurosteroidogenic enzymes in the brains of vertebrates (Bruzzone et al, 2010;Takase et al, 1999;Ukena et al, 1999a,b). The widespread occurrence of GABAergic cells bodies/fibers or GABA/glutamate binding sites in various nervous structures that contain steroidogenic cells has also been reported suggesting that neurosteroids can modulate some of the central effects of the neurotransmitters (Do Rego et al, 2009;Agìs-Balboa et al, 2006).…”