Immunohistochemical Localization of Carcinoembryonic Antigen(CEA) in Squamous Cell Carcinoma of the Uterine Cervix: Prognostic Significance of Localization Pattern of CEA.

Toki, Toshihiko; Yajima, Akira

doi:10.1620/tjem.165.25

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Moreover, some papers also describe the expression of D2-40 in a subset of squamous cell carcinomas [ 24 - 26 ]. Other markers such as CEA, cytokeratin 7, as well as the estrogen and progesterone receptors are not helpful in distinguishing these tumors [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Expression of HNF-1β in cervical carcinomas: an immunohistochemical study of 155 cases

2015

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BackgroundHNF-1β is a commonly used marker in the differential diagnosis of clear cell carcinoma of the ovary and endometrium. Recent studies have found HNF-1β expression to a lesser extent in other ovarian and endometrial tumors including endometrioid, mucinous and, rarely, serous carcinoma. Regarding cervical carcinoma, HNF-1β expression has been mentioned exceptionally in mesonephric and some other types of adenocarcinoma. However, a systematic analysis of HNF-1β expression in cervical carcinomas has not been performed to date.MethodsWe analyzed HNF-1β expression in 155 cervical carcinomas (including 56 adenocarcinomas, 85 squamous cell carcinomas and 14 undifferentiated carcinomas). Expression of HNF-1β was correlated with the expression of other markers including estrogen receptors, progesterone receptors, CEA, p63, p40, p16, and D2-40.ResultsAdenocarcinomas showed expression of HNF-1β in 42/56 cases (75%), CEA in 48/56 cases (85.7%), p63 in 4/56 cases (7.2%), p40 in 2/56 cases (3.6%), estrogen receptors in 9/56 cases (16.1%), progesterone receptors in 5/56 cases (8.9%), p16 in 56/56 (100%) cases, and D2-40 in 0/56 cases (0%). Squamous cell carcinomas showed expression of HNF-1β in 2/85 cases (2.35%), CEA in 77/85 cases (90.6%), p63 and p40 in 85/85 cases (100%), estrogen receptors in 9/85 cases (10.6%), progesterone receptors in 1/85 cases (1.2%), p16 in 84/85 cases (98.8%), and D2-40 in 45/84 cases (53.6%). Undifferentiated carcinomas showed expression of HNF-1β in 2/14 cases (14.3%), CEA in 8/14 cases (57.1%), p16 in 14/14 cases (100%), hormone receptors in 0/13 cases (0%), p63 in 7/14 cases (50%), p40 in 5/14 cases (35.7%), and D2-40 in 1/14 cases (7.1%).ConclusionsIn cervical carcinoma, expression of HNF-1β is mostly restricted to adenocarcinomas and can be used as an auxiliary adenocarcinoma marker in the differential diagnosis of poorly differentiated cervical carcinomas. HNF-1β as an adenocarcinoma marker and p63/p40 and D2-40 as a squamous cell carcinoma markers are highly specific with variable sensitivity. Optimal results can be achieved using these markers in a panel.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1348836442160205.

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Section: Discussionmentioning

confidence: 99%

Expression of HNF-1β in cervical carcinomas: an immunohistochemical study of 155 cases

2015

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“…The TAA CEA molecule was found to be expressed on normal cervical tissues [212,213] and the expression increases with disease progression from CIN to invasive squamous cell carcinoma [212,[214][215][216][217]. However, no differences on survival rates could be observed in patients in relation with CEA expression [214], whereas among CEA + squamous cell carcinoma of the uterine cervix prognostic significance is acquired for the diffuse and focal localization of positive pattern of CEA in cancer nests [217]. Elevated serum levels of CA125 are detectable in 20-75% cervical adenocarcinoma patients and in a smaller percentage of patients with the squamous cell histotype [218,219].…”

Section: Tumor Associated Antigensmentioning

confidence: 99%

Immunology of Gynecologic Neoplasms: Analysis of the Prognostic Significance of the Immune Status

Bellati¹,

Visconti

Napoletano³

et al. 2009

CCDT

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Gynecologic Oncology has changed in the last few decades. An increasing proportion of patients is benefiting from long term survival although patients diagnosed with advanced disease suffer from a poor prognosis. Unfortunately, several recent studies are confirming that changing the combinations of "traditional" cytotoxic drugs is unlikely to obtain a real breakthrough in survival rates. Furthermore, there is discouraging data regarding consolidation therapies. It is, therefore, necessary to identify new target therapies with a minimal impact on quality of life. It is likely that new breakthroughs are only going to be achieved when changes in therapies are tailored to the entire natural history of the disease and on specific patient characteristic's. Since the discovery that tumor infiltrating lymphocytes represent an independent prognostic factor in ovarian cancer patients, several researchers have dedicated their attention to cancer immune response in order to identify prognostic factors and immunological targets. Analyses on immunophenotype at diagnosis and throughout the entire course of treatment are currently ongoing and are giving the new diagnostic, prognostic and therapeutic tools to the physicians. Furthermore new antigens and new vaccination strategies are being investigated. Encouraging data on selected patient populations have been observed recently. The objective of the present review is to define the immunology of women affected by gynecological malignancies and describe new immunological targets for prognostic and therapeutic use.

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“…Regarding the immunohistochemical examination, it is important to remember that squamous cervical carcinoma can present an immunophenotype with positive cytokeratin 7 (CK7) and carcinoembryonic antigen (CEA) antibodies. The hormonal receptor ER and PR show decreased expression in cervical intraepithelial neoplasia and negative for invasive squamous cervical carcinoma 37 - 40. Those findings can lead to the misdiagnosis of adenocarcinoma, especially in poorly differentiated tumors.…”

Section: Discussionmentioning

confidence: 99%

Intramuscular metastatic squamous cell carcinoma of the cervix: autopsy case report

Ferreira¹,

Testagrossa²,

Campos³

et al. 2012

ACR

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Cancer of the uterine cervix is the fourth leading cause of death in women in Brazil, accounting for 4800 fatal cases per year. The histology of this neoplasia is mainly represented by squamous cell carcinoma (80-85%), adenocarcinomas (10-15%), and, more rarely, mixed carcinomas. The Papanicolaou (Pap) smear test is the method of excellence in detecting incipient or pre-malignant lesions. Since its implementation, the Pap test has been reducing the incidence of this neoplasia worldwide, despite its lack of high sensitivity and specificity. Both incidence and mortality from cervical cancer have sharply decreased following the introduction of well-run screening programs. The cervical cancer typically spreads to adjacent structures by contiguity; pelvic and para-aortic lymph nodes are involved by lymphatic dissemination. Less frequently, hematogenic spread is observed, and when it occurs, the brain, breast, and skeletal muscle are rarely involved. The authors report a case of a young woman who underwent periodical gynecological examination with negative Pap tests and presented to the hospital with an advanced cervical metastatic disease involving thyroid, muscles, lymph nodes, and breast (among others sites). The diagnosis of the primary site was not elucidated during life. The patient died, and at autopsy an endophytic squamous cell carcinoma of the cervix was diagnosed.

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Immunohistochemical Localization of Carcinoembryonic Antigen(CEA) in Squamous Cell Carcinoma of the Uterine Cervix: Prognostic Significance of Localization Pattern of CEA.

Cited by 5 publications

References 12 publications

Expression of HNF-1β in cervical carcinomas: an immunohistochemical study of 155 cases

Expression of HNF-1β in cervical carcinomas: an immunohistochemical study of 155 cases

Immunology of Gynecologic Neoplasms: Analysis of the Prognostic Significance of the Immune Status

Intramuscular metastatic squamous cell carcinoma of the cervix: autopsy case report

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