Immunohistochemical localization of fibroblast growth factor‐1 (FGF‐l)and FGF‐2 in cultured human ameloblastoma epithelial cells and ameloblastoma tissues

Myoken, Yoshinari; Okamoto, Tomoyoshi; Sato, Jun; Takada, Kazuaki

doi:10.1111/j.1600-0714.1995.tb01206.x

Cited by 18 publications

(15 citation statements)

References 20 publications

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“…There are a number of papers reporting the immunohistochemical expression of intermediate filaments, 15 growth factors, 16 basement membrane components, 17 cell cycle regulating factors 18 –21 and apoptotic proteins 22 , 23 in ameloblastomas but calcium‐binding proteins have not been investigated in these tumours.…”

Section: Discussionmentioning

confidence: 99%

Calretinin expression in ameloblastomas

Altini

Coleman

Doglioni³

et al. 2000

Histopathology

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Section: Discussionmentioning

confidence: 99%

Calretinin expression in ameloblastomas

Altini

Coleman

Doglioni³

et al. 2000

Histopathology

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“…In comparison with the ordinary ameloblastoma [7,15,16,17,26,30,32,35], there have been only a few studies on the immunoprofile of various proteins in DA. Siar and Ng [28] described differences in the expression of some antigens such as keratin and vimentin between DA and ordinary ameloblastomas.…”

Section: Discussionmentioning

confidence: 99%

Immunoexpression of transforming growth factor β in desmoplastic ameloblastoma

Takata¹,

Miyauchi²,

Ogawa³

et al. 2000

Virchows Archiv

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Desmoplastic ameloblastoma (DA) is an unusual subtype of ameloblastoma histologically characterized by the pronounced collagenized stroma. In the present study, the immunolocalization of transforming growth factor beta (TGF-beta), one of the most potent local factors for modulating extracellular matrix formation, was observed in DA in order to study its participation in the stromal desmoplasia. Seven cases of DA, including a "hybrid" lesion, were studied together with ten cases of ordinary follicular and plexiform ameloblastomas as the control. In contrast to ordinary ameloblastomas, marked immunoexpression was observed in all DAs but one. In the "hybrid" lesion, TGF-beta was not expressed in the area of follicular ameloblastoma but in that of DA. These results show that TGF-beta produced by tumor cells of DA plays a part in the desmoplastic matrix formation.

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“…Myoken et al . [29] established a serum-free culture system for ameloblastoma cells and demonstrated the addition of fibroblast growth factor-1 (FGF-1) and fibroblast growth factor-2 (FGF-2), which are mitogenic polypeptides that may contribute to neoplastic cell proliferation, and enhance cell growth in a dose-dependent manner. Ameloblast-like cells and stellate reticulum-like cells presented a high expression of FGF-1, whereas FGF-2 was identified mainly in the basement membrane.…”

Section: Molecular Markers Involved In Angiogenesismentioning

confidence: 99%

Molecular markers of tumor invasiveness in ameloblastoma: An update

Zhong

Guo

Wang

et al. 2011

Ann Maxillofac Surg

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The aim of the present article was to review the current new knowledge on the molecular markers of tumor invasion in ameloblastoma. In this review, tumor molecular markers were identified and allocated to the following six groups according to their functions: (I) Markers involved in extracellular matrix degradation, (II) Molecular markers involved in cell adhesion lost, (III) Molecular markers involved in bone remodeling, (IV) Cytokines involved in angiogenesis, (V) Molecular markers related with the function of tumor stromal cells on the invasion of ameloblastoma, and (VI) Molecular markers involved in cell proliferation related with invasion.In general, the location of markers within the tumor and not their quantitative assessments as such is emphasized. Data showed that the correlation among molecular markers of invasive relevance is still not quite clear. Results on markers of tumor invasion and metastatic potential appeared to be too premature for a statement regarding the instinct invasive nature of ameloblastoma. The unraveling of specific new details concerning these mechanisms, whereby the expression and relationships among the molecules are mediated, may provide an opportunity to afford efficient prevention and develop new treatment therapies.

show abstract

Immunohistochemical localization of fibroblast growth factor‐1 (FGF‐l)and FGF‐2 in cultured human ameloblastoma epithelial cells and ameloblastoma tissues

Cited by 18 publications

References 20 publications

Calretinin expression in ameloblastomas

Calretinin expression in ameloblastomas

Immunoexpression of transforming growth factor β in desmoplastic ameloblastoma

Molecular markers of tumor invasiveness in ameloblastoma: An update

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