Immunohistochemical localization of insulin in nesidoblastosis of rat pancreas.

Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model

“…However, in the 1980s, a related compound, the ␤-cell toxin streptozotocin, was administered to neonatal rats and produced an endocrine cell renewal similar to that reported previously for alloxan (Cantenys et al, 1981). There is controversy, though, regarding whether this phenomenon occurs in older animals (Komai et al, 1981;Michels et al, 1987;Morohoshi et al, 1984).…”

Factors Controlling Pancreatic Islet Neogenesis

“…Alloxan administration is followed by an increased number of small islets seen during the regenerative phase [8], These islets are comprised almost exclusively of insulin-con taining cells budding from small ductules [9,10], In neonatal rats, the administration of the P-cell toxin streptozotocin (S I Z) is followed by a similar endocrine cell renewal [11], There is controversy, however, as to whether this phenomenon occurs in older animals [12][13][14], A related compound, the carcinogen N-nitroso-bis(2-oxopropyl)amine, induces new is let formation during carcinogenesis, but tu mor eventually replaces the islets [15], There fore, this model is not appropriate to study normal islet cell differentiation.…”