Immunohistochemical Localization of Insulin-Like Growth Factor 1 Receptors in Benign and Malignant Tissues of the Female Genital Tract

Weigang, Beate; Nap, Marius; Bittl, Andreas; Jaeger, Wolfram

doi:10.1159/000217897

Cited by 18 publications

(7 citation statements)

References 34 publications

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“…This study suggested that all necessary components for an IGF-I-mediated autocrine loop are present in ovarian cancer cells, an observation that was also confirmed in one of our early studies using the OVCAR-3 cell line [38]. Two other groups described the expression of the IGF and insulin receptors in ovarian tumors [39, 40]. During the same period, it was reported that IGF-I levels were higher in cyst fluid from invasive malignant neoplasms compared to benign tumors [41].…”

Section: Components Of the Igf Axis Expression In Human Ovarian Casupporting

confidence: 66%

Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer

Beauchamp

Yasmeen

Knafo

et al. 2010

Journal of Oncology

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Ovarian cancer is the most lethal of all gynecological malignancies, due in part to the diagnosis at an advanced stage caused by the lack of specific signs and symptoms and the absence of reliable tests for screening and early detection. Most patients will respond initially to treatment but about 70% of them will suffer a recurrence. Therefore, new therapeutic modalities are urgently needed to overcome chemoresistance observed in ovarian cancer patients. Evidence accumulates suggesting that the insulin/insulin growth factor (IGF) pathways could act as a good therapeutic target in several cancers, including ovarian cancer. In this paper, we will focus on the role of insulin/IGF in ovarian cancer tumorigenesis and treatment.

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Section: Components Of the Igf Axis Expression In Human Ovarian Casupporting

confidence: 66%

Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer

Beauchamp

Yasmeen

Knafo

et al. 2010

Journal of Oncology

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“…High circulating levels of IGF-1 have been implicated as a risk and a poor prognosis factor in cancers of the breast, uterus, prostate and colon [50, 55-57]. In ovarian cancer, multiple reports have shown high levels of IGF-1 in cancer cells and in blood, along with increased expression of its receptor [54, 58, 59]. The collective signaling initiated by both insulin and IGF-1 primarily converges on the activation of the PI3K/Akt pathway, leading to the downstream activation of mTOR [52, 60, 61].…”

Section: Discussionmentioning

confidence: 99%

Dietary energy balance modulates ovarian cancer progression and metastasis

et al. 2014

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A high energy balance, or caloric excess, accounts as a tumor promoting factor, while a negative energy balance via caloric restriction, has been shown to delay cancer progression. The effect of energy balance on ovarian cancer progression was investigated in an isogeneic immunocompetent mouse model of epithelial ovarian cancer kept on a regimen of regular diet, high energy diet (HED) and calorie restricted diet (CRD), prior to inoculating the animals intraperitoneally with the mouse ovarian surface epithelial ID8 cancer cells. Tumor evaluation revealed that mice group on HED displayed the most extensive tumor formation with the highest tumor score at all organ sites (diaphragm, peritoneum, bowel, liver, kidney, spleen), accompanied with increased levels of insulin, leptin, insulin growth factor-1 (IGF-1), monocyte chemoattractant protein-1 (MCP-1), VEGF and interleukin 6 (IL-6). On the other hand, the mice group on CRD exhibited the least tumor burden associated with a significant reduction in levels of insulin, IGF-1, leptin, MCP-1, VEGF and IL-6. Immunohistochemistry analysis of tumors from HED mice showed higher activation of Akt and mTOR with decreased adenosine monophosphate activated kinase (AMPK) and SIRT1 activation, while tumors from the CRD group exhibited the reverse profile. In conclusion, ovarian cancer growth and metastasis occurred more aggressively under HED conditions and was significantly curtailed under CRD. The suggested mechanism involves modulated secretion of growth factors, cytokines and altered regulation of AMPK and SIRT1 that converges on mTOR inhibition. While the role of a high energy state in ovarian cancer has not been confirnmed in the literature, the current findings support investigating the potential impact of diet modulation as adjunct to other anticancer therapies and as possible individualized treatment strategy of epithelial ovarian cancer.

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“…Insulin-like growth factor-1 was detected in the OC stroma, with strongest expression around vessels, with less frequent and weaker expression in tumor cells (92). …”

Section: Ecm Proteins and Their Receptorsmentioning

confidence: 99%

The Role of the Tumor Stroma in Ovarian Cancer

2014

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The tumor microenvironment, consisting of stromal myofibroblasts, endothelial cells, and leukocytes, is growingly perceived to be a major contributor to the pathogenesis and disease progression in practically all cancer types. Stromal myofibroblasts produce angiogenic factors, proteases, growth factors, immune response-modulating proteins, anti-apoptotic proteins, and signaling molecules, and express surface receptors and respond to stimuli initiated in the tumor cells to establish a bi-directional communication network in the microenvironment to promote tumor cell invasion and metastasis. Many of these molecules are candidates for targeted therapy and the cancer stroma has been recently regarded as target for biological intervention. This review provides an overview of the biology and clinical role of the stroma in ovarian cancer.

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Immunohistochemical Localization of Insulin-Like Growth Factor 1 Receptors in Benign and Malignant Tissues of the Female Genital Tract

Cited by 18 publications

References 34 publications

Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer

Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer

Dietary energy balance modulates ovarian cancer progression and metastasis

The Role of the Tumor Stroma in Ovarian Cancer

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