Immunohistochemical localization of irisin in skin, eye, and thyroid and pineal glands of the crested porcupine<i>(Hystrix cristata)</i>

Tarakçi, Berrin Gençer; Girgin, Aydın; Timurkaan, Sema; Yalçın, Mehmet Hanifi; Gur, F. M.; Karan, Meryem

doi:10.1080/10520295.2016.1183820

Cited by 19 publications

(7 citation statements)

References 17 publications

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“…In the study by Huh et al, FNDC5 expression was also identified in the thyroid, however, at a much lower level than in tissues containing muscle fibres . The thyroid gland of the crested porcupine (Hystrixcristata) has also been described to exhibit irisin immunoreactivity . As other metabolically active novel peptides, such as ghrelin, obestatin or visfatin, are influenced by thyroid hormones levels, this influence on irisin concentration has become an interesting focus of research.…”

Section: Introductionmentioning

confidence: 99%

The association between irisin and muscle metabolism in different thyroid disorders

Zybek-Kocik

Sawicka‐Gutaj

Szczepanek‐Parulska

et al. 2017

Clinical Endocrinology

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Section: Introductionmentioning

confidence: 99%

The association between irisin and muscle metabolism in different thyroid disorders

Zybek-Kocik

Sawicka‐Gutaj

Szczepanek‐Parulska

et al. 2017

Clinical Endocrinology

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“…9 Moreover, irisin immunoreactivity was found in the neural retina of the crested porcupine (Hystrix cristata). 20 To our knowledge, this is the only study showing that irisin exists in the human aqueous humor.…”

Section: Discussionmentioning

confidence: 82%

High irisin and low BDNF levels in aqueous humor of high myopia

Wang¹,

Li²,

Zheng³

et al. 2021

Adv Clin Exp Med

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Background. The pathogenesis of myopia remains unclear. Both genetic and environmental factors play a role in the disease progression. Reasons including reduced physical activity (PA) and low-grade intraocular inflammation may be involved in the development of myopia. Objectives.To analyze the levels of irisin, brain-derived neurotrophic factor (BDNF) and other intraocular cytokines in aqueous humor of high myopia patients, and to evaluate the roles of PA and inflammation in developing myopia. Materials and methods.We collected aqueous humor samples from patients with axial length (AL) over 26 mm (n = 35) or shorter than 25 mm (n = 38) during cataract extraction surgery. Samples were assayed using the enzyme-linked immunosorbent assay (ELISA) kit for irisin and a multiplex immunoassay kit for BDNF, interleukin (IL)-6, IL-8 and IL-10, and tumor necrosis factor alpha (TNF-α).Results. Irisin levels in the aqueous samples of the highly myopic eyes were significantly higher than in the control group (p = 0.027). The BDNF levels of the highly myopic group were significantly lower than in the control group (p = 0.043). Median level of leukemia inhibitory factor (LIF) for highly myopic group (2.035 pg/mL) was statistically significantly higher than in the control group (0.750 pg/mL) (U = 210.5, Z = −4.495, p < 0.001). Interleukin 1 receptor antagonist (IL-1ra) level in the aqueous samples of the highly myopic group was significantly lower than in the shorter AL group (p = 0.049). Interleukin 6, IL-8 and IL-10 levels were not significantly different between the 2 groups (p = 0.501, p = 0.059 and p = 0. 192, respectively). Tumor necrosis factor α levels could only be detected in 30 samples and median levels in the 2 groups were not statistically significantly different

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“…Moreover, the immunoreactivity of irisin was observed in the cornea ( 23 ). Another study of crested porcupine ( Hystrix cristata ) showed the immunoreactivity of irisin in the neural retina ( 24 ). Recently, two studies identified that irisin could be detected in the human aqueous humor and one study found that it could be detected in the vitreous humor ( 22 , 25 , 26 ).…”

Section: Discussionmentioning

confidence: 99%

The Changes of Irisin and Inflammatory Cytokines in the Age-Related Macular Degeneration and Retinal Vein Occlusion

Cao

Zhao

et al. 2022

Front. Endocrinol.

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PurposeAge-related macular degeneration (AMD) and retinal vein occlusion (RVO) are irreversible chorioretinal diseases, which might induce severe damage in visual function. The metabolic factor and inflammatory factors might play important roles in the pathogenesis of AMD and RVO. The levels of irisin and 14 cytokines were analyzed in aqueous humor of AMD and RVO eyes to evaluate the roles of irisin and inflammatory factors.MethodsWe collected aqueous humor samples from patients with AMD (n = 27), RVO (n = 30), and cataract (as control, n = 23) eyes. Samples were assayed using ELISA kit for irisin and a multiplex immunoassay kit for 14 cytokines. The macular thickness (MT) was measured with OCT in all included eyes.ResultsMT in the RVO group is significantly higher than that in the AMD or control group. Irisin levels in the aqueous samples of AMD and RVO eyes were both significantly lower than that in the control. Furthermore, a positive correlation was found between irisin and MT in the RVO. Compared with the controls, AMD eyes had significantly higher levels of BDNF, VEGF-A, VEGF-R1, VEGF-R2, IL-10, TNF-α, VCAM-1, IP-10, and MCP-1. Similarly, RVO eyes had significantly higher levels of BDNF, VEGF-A, VEGF-R1, VEGF-R2, IL-6, IL-8, IL-10, TNF-α, ICAM-1, VCAM-1, IP-10, and MCP-1. However, there was no significant difference between the levels of PDGF-BB or TNF-β in these three groups. A negative correlation was found between VEGF-A and MT in AMD, as well as in control. Furthermore, a positive correlation was found between IL-6 and MT in the 80 included eyes, as well as in RVO. A positive correlation was found between ICAM-1 and MT in the 80 included eyes, as well as in RVO.ConclusionsThe metabolic factor, irisin levels in the aqueous humor are decreased in AMD and RVO eyes and show a positive correlation between irisin and MT in RVO eyes, prompting researchers to explore the relationship between irisin and macular edema. We also identified the higher expression of vascular growth factors (VEGF-A, VEGF-R1, and PDGF-BB), inflammatory cytokines (IL-6, IL-8, IL-10, and TNF-α), and chemokines (ICAM-1, VCAM-1, IP-10, and MCP-1) in AMD and RVO eyes.

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Immunohistochemical localization of irisin in skin, eye, and thyroid and pineal glands of the crested porcupine(Hystrix cristata)

Cited by 19 publications

References 17 publications

The association between irisin and muscle metabolism in different thyroid disorders

The association between irisin and muscle metabolism in different thyroid disorders

High irisin and low BDNF levels in aqueous humor of high myopia

The Changes of Irisin and Inflammatory Cytokines in the Age-Related Macular Degeneration and Retinal Vein Occlusion

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