Immunohistochemical localization of mast cells and mast cell‐nerve interactions in oral lichen planus

Zz, Zhao; Savage, N. W.; Pujic, Zac; Walsh, L. J.

doi:10.1111/j.1601-0825.1997.tb00015.x

Cited by 45 publications

(41 citation statements)

References 17 publications

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“…Alterations in the number of SP-reactive fibers and mast cell-nerve contacts have been reported as parts of the pathology of several diseases (3,19,45). SP can activate mast cells both through binding of the neurokinin-1 receptor present on these cells (8) and through receptor-independent mechanisms (10).…”

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confidence: 99%

Lowering of interstitial fluid pressure after neurogenic inflammation in mouse skin is partly dependent on mast cells

Karlsen¹,

Bletsa²,

Gjerde³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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Neurogenic inflammation is known to induce lowering of interstitial fluid pressure (P if) in mouse skin. This study examined the possible role of mast cell activation secondary to neuropeptide release in lowering of P if by using , and neurokinin A, from the capsaicin-sensitive nerve endings. Capsaicin releases neuropeptides through binding to the vanilloid receptor subtype 1 (VR1) (9), which in turn induces an inflammatory response in various tissues of both rodents and humans (2, 21). This response is characterized by increased arteriolar vasodilatation and protein extravasation due to increased permeability of the postcapillary venules resulting in fluid accumulation in the tissue. Previous reports from our research group have shown that the response in the initial phase of neurogenic inflammation involves lowering of interstitial fluid pressure (P if ) as observed both in rat trachea (16) and mouse skin (25). P if is important in tissue fluid homeostasis both in the regulation of fluid filtration across the capillary and as the filling pressure for the lymphatics (1). In contrast to the classic view of P if serving as an edema-preventing mechanism, P if has been shown to play an active part in the initial phase of edema in a number of inflammatory models with a lowering of P if to more negative values (16,31,34,35). According to Starling's hypothesis, this lowering of P if will increase net filtration pressure across the capillary and hence contribute to fluid accumulation in the interstitial space.Mast cells have been thought of as possible participants in the neurogenic inflammatory response because they contain numerous inflammatory mediators and are localized in close proximity to the capsaicin-sensitive nerve endings (37,39). Alterations in the number of SP-reactive fibers and mast cell-nerve contacts have been reported as parts of the pathology of several diseases (3,19,45). SP can activate mast cells both through binding of the neurokinin-1 receptor present on these cells (8) and through receptor-independent mechanisms (10). The significance of mast cell activation as a part of neurogenic inflammation has been questioned in a number of studies, and the results are yet not conclusive. Supporting the involvement of mast cells are the findings that stimulation of the rat saphenous nerve induces mast cell degranulation (27) and that SP in high concentrations (40) as well as topical application of capsaicin (7) induce cutaneous mast cell degranulation in human forearm. In contrast, Petersen et al. (32) detected no release of SP and histamine after capsaicin injection in the same area.In light of the knowledge that capsaicin-sensitive nerve endings are localized close to connective tissue mast cells (CTMCs) in mouse skin (6) and that mast cell activation by compound 48/80 (C48/80) induces a lowering of P if in skin of both rats and mice (20,25,36), the question arises as to whether mast cells are involved in the events leading to lowering of P if in neurogenic inflammation. In a recent study (25) we exami...

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mentioning

confidence: 99%

Lowering of interstitial fluid pressure after neurogenic inflammation in mouse skin is partly dependent on mast cells

Karlsen¹,

Bletsa²,

Gjerde³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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“…All 12 studies had answered the 1st research question of the mast cell number in OLP patients. 5 studies had used toluidine blue‐based staining to count the number of the mast cells.…”

Section: Resultsmentioning

confidence: 99%

“…5 studies had used toluidine blue‐based staining to count the number of the mast cells. 4 studies had used anti‐tryptase antibody staining to detect the mast cells. 1 study by Gholamreza et al had compared the mast cell numbers from both toluidine blue staining and anti‐tryptase antibody‐based staining, and another unique study by Balci et al examined the mast cell counts by toluidine blue staining with CD1177 (C‐Kit) methods.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 4 studies had used an ocular grid to count the mast cell numbers in sequential fields. 4 studies had counted in 5 sequential high‐power fields, and 1 study had used 10 high‐power fields .…”

Section: Resultsmentioning

confidence: 99%

“…The mast cells can be identified by toluidine blue stain which stains the granules metachromatically and also by immunohistochemical labeling by using antibodies to tryptase and chymase in the specimen …”

Section: Introductionmentioning

confidence: 99%

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Mast cell expression in oral lichen planus: A systematic review

Vadivel

Govindarajan²,

Somasundaram

et al. 2019

J of Invest & Clin Dent

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Lichen planus is a common chronic, inflammatory, immune‐mediated mucocutaneous disorder affecting the skin and mucosa. The role of mast cells in the genesis of lichen planus has been debated. Establishing a definitive part played by mast cells and its degranulation would possibly provide a permanent, cost‐effective treatment modality for oral lichen planus (OLP). This review aims to study the expression of mast cells qualitatively and quantitatively in OLP. The research questions were framed to assess the mast cell count, localization within the epithelium basement membrane zone and degranulation of mast cells. We performed a systematic search of PubMed, Medline, Cochrane and Web of Science. We found a total of 120 studies from which 12 were found suitable for the review. There is a marked increase in the number of mast cells in OLP. The mast cells were seen in increased numbers in the epithelial and connective tissue junction at areas of basement membrane disruption. There was also an increase in the degranulation of mast cells. It is evident that there is an increase in the mast cell number in lichen planus and its subsequent degranulation.

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The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy

et al. 2023

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Diabetes is a significant public health issue known as the world's fastestgrowing disease condition. It is characterized by persistent hyperglycemia and subsequent chronic complications leading to organ dysfunction and, ultimately, the failure of target organs. Substance P (SP) is an undecapeptide that belongs to the family of tachykinin (TK) peptides. The SP-mediated activation of the neurokinin 1 receptor (NK1R) regulates many pathophysiological processes in the body. There is also a relation between the SP/NK1R system and diabetic processes. Importantly, deregulated expression of SP has been reported in diabetes and diabetes-associated chronic complications. SP can induce both diabetogenic and antidiabetogenic effects and thus affect the pathology of diabetes destructively or protectively. Here, we review the current knowledge of the functional relevance of the SP/NK1R system in diabetes pathogenesis and its exploitation for diabetes therapy. A comprehensive understanding of the role of the SP/NK1R system in diabetes is expected to shed further light on developing new therapeutic possibilities for diabetes and its associated chronic conditions.

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Immunohistochemical localization of mast cells and mast cell‐nerve interactions in oral lichen planus

Cited by 45 publications

References 17 publications

Lowering of interstitial fluid pressure after neurogenic inflammation in mouse skin is partly dependent on mast cells

Lowering of interstitial fluid pressure after neurogenic inflammation in mouse skin is partly dependent on mast cells

Mast cell expression in oral lichen planus: A systematic review

The neuropeptide substance P/neurokinin‐1 receptor system and diabetes: From mechanism to therapy

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