Immunohistochemical localization of surfactant apoproteins in usual interstitial pneumonia associated with pulmonary carcinoma

Chung, Jin Haeng; Kitaichi, Masanori; Ham, Eui Keun; Seo, Jeong‐Wook

doi:10.1002/(sici)1097-0029(19980801)42:3<234::aid-jemt8>3.0.co;2-s

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…The significance of these hyperplastic cells is still not clear. [7][8][9][10][32][33][34] In conclusion, in this study at least one third of the large cell carcinomas of the lung were SP-A positive. This finding may suggest that such tumors take their origin from the same cell type or show a similar differentiation as bronchioloalveolar carcinomas, since more than 80% of bronchioloalveolar carcinomas are SP-A positive.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 Some investigators evaluated the expression of SP-A in a variety of nonmalignant disorders [7][8][9] and in interstitial pneumonia associated with pulmonary carcinoma. 10 Several papers reported SP-A expression in alveolar adenoma of the lung, 11,12 sclerosing hemangioma of the lung, 13 bronchioloalveolar carcinoma, and other types of lung adenocarcinoma. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] The expression of SP-A in tumor cells of large cell carcinoma of the lung has not been well studied.…”

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confidence: 99%

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Surfactant Protein A Detection in Large Cell Carcinoma of the Lung

Uzaslan¹,

Ebsen

Stuempel

et al. 2006

Applied Immunohistochemistry &Amp; Molecular Morphology

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Large cell carcinomas of the lung are undifferentiated malignant epithelial tumors that lack cytologic features of small cell carcinoma, glandular cell carcinoma, or squamous cell differentiation. Lung surfactant protein A (SP-A) is produced by alveolar type II cells and Clara cells. Most bronchioloalveolar carcinomas of the lung react positively for SP-A. Positive SP-A staining of large cell carcinoma of the lung could indicate that at least part of these tumors have the same cellular origin or differentiation as bronchioloalveolar carcinoma. The authors determined the SP-A staining of 63 large cell carcinomas of the lung by IHC. In 20 of the 63 (32%), the tumors stained positive for SP-A. This may imply that about one third of large cell carcinomas of the lung have a similar cellular origin or differentiation as bronchioloalveolar carcinoma. The significance of this finding for prognosis and new forms of treatment remains to be determined.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Surfactant Protein A Detection in Large Cell Carcinoma of the Lung

Uzaslan¹,

Ebsen

Stuempel

et al. 2006

Applied Immunohistochemistry &Amp; Molecular Morphology

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“…However, available data regarding the histotype and phenotype of carcinomas in IPF patients are limited. Chung et al . described five tumours (two squamous carcinomas, one adenocarcinoma, one adenosquamous carcinoma, and one large‐cell carcinoma) that all lacked surfactant protein A (SPA1) and surfactant protein B in neoplastic cells.…”

Section: Introductionmentioning

confidence: 99%

Increased frequency of bronchiolar histotypes in lung carcinomas associated with idiopathic pulmonary fibrosis

et al. 2017

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Solitary Atypical Adenomatous Hyperplasia in the Lung of a 17-Year-Old Man with Spontaneous Pneumothorax

Tanaka

Isowa²,

Hasegawa³

et al. 2003

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We report here a case of solitary atypical adenomatous hyperplasia (AAH). A 17-year-old non-smoker man developed spontaneous pneumothorax, and computed tomogram scanning of his chest revealed a ground-glass opacity measuring 5 × 5 mm in the right lung with no change in its size for the next 7 months. To exclude the possibility of pulmonary neoplasia, he underwent partial pulmonary resection. The postoperative pathologic diagnosis was AAH. The present case is very exceptional for AAH because of the patient’s young age and non-association with pulmonary carcinoma. The postoperative 23-month follow-up was uneventful.

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Immunohistochemical localization of surfactant apoproteins in usual interstitial pneumonia associated with pulmonary carcinoma

Cited by 4 publications

References 12 publications

Surfactant Protein A Detection in Large Cell Carcinoma of the Lung

Surfactant Protein A Detection in Large Cell Carcinoma of the Lung

Increased frequency of bronchiolar histotypes in lung carcinomas associated with idiopathic pulmonary fibrosis

Solitary Atypical Adenomatous Hyperplasia in the Lung of a 17-Year-Old Man with Spontaneous Pneumothorax

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