Immunohistochemical mapping of NPR-A in the brainstem of macaca fascicularis

Abdelalim, Essam M.; Osman, Abdel‐Hamid K.; Takada, Tatsuyuki; Torii, Ryuzo; Tooyama, Ikuo

doi:10.1016/j.neures.2007.06.457

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“…The presence of natriuretic peptides and their receptors has been reported in monkey brain (Wilcox et al 1991;Abdelalim et al 2006Abdelalim et al , 2007, indicating a central role for natriuretic peptides in this species. A previous study in the monkey reported that NPR-B mRNA expression was confined to the adrenal medulla, pituitary, and cerebellum (Wilcox et al 1991).…”

Section: Introductionmentioning

confidence: 88%

“…Bars = 100 lm (a, c, e, g); 50 lm (b, d, f, h, i) Comparing the distribution of NPR-B immunoreactivity with that of other natriuretic peptide receptors in the brainstem seems to indicate a close anatomical relationship between these receptors, because in both the monkey and rat, NPR-A and NPR-C receptors were found in some regions in which NPR-B receptors were also found, suggesting the possible coexistence of natriuretic peptide receptors. For example, in the monkey, NPR-A Funct (2011) 216:387-402 397 immunoreactivity was found in the oculomotor nucleus, red nucleus, parabrachial nucleus, locus coeruleus, gracile nucleus, cuneate nucleus, dorsal motor nucleus of the vagus, hypoglossal nucleus, lateral reticular nucleus, nucleus ambiguus, and inferior olivary nucleus (Abdelalim et al 2007). In the rat, NPR-C immunoreactivity was found in the PAG, oculomotor nucleus, substantia nigra, VTA, facial nucleus parabrachial nucleus, locus coeruleus, dorsal motor nucleus of the vagus, hypoglossal nucleus, lateral reticular nucleus, and the inferior olivary nucleus Overall, NPR-B immunoreactivity detected in the present study was more widely distributed in the brainstem than the other natriuretic peptide receptors (NPR-A and NPR-C).…”

Section: Distribution Of Npr-b Immunoreactivity In the Brainstemmentioning

confidence: 99%

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Mapping of NPR-B immunoreactivity in the brainstem of Macaca fascicularis

Abdelalim

Tooyama

2011

Brain Struct Funct

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C-type natriuretic peptide (CNP), the most abundant natriuretic peptide hormone in the brain, plays an important role in neuroendocrine function. The physiological effects of CNP are mediated by the natriuretic peptide receptor-B (NPR-B). Although CNP and NPR-B have been detected in several brain regions, little is known about the neuroanatomical localization of NPR-B protein in the brainstem. In the present study, we investigated the topographical distribution of NPR-B immunoreactivity in the monkey brainstem. The data demonstrate widespread NPR-B immunoreactivity throughout the brainstem. NPR-B immunoreactivity was located in the superior colliculus, inferior colliculus, periaqueductal gray, oculomotor nucleus, red nucleus, ventral tegmental area, substantia nigra, and cerebral peduncle of the midbrain, as well as in the abducens nucleus, medial vestibular nucleus, lateral vestibular nucleus, parabrachial nucleus, locus coeruleus, trigeminal motor nucleus, pontine reticular nucleus, facial nucleus, oral part of the spinal trigeminal nucleus, cochlear nucleus, raphe magnus nucleus, raphe pallidus nucleus, pontine nucleus of the pons, the dorsal motor nucleus of the vagus, hypoglossal nucleus, nucleus tractus solitarius, gracile nucleus, cuneate nucleus, medial vestibular nucleus, spinal trigeminal nucleus, nucleus ambiguus, lateral paragigantocellular nucleus, lateral reticular nucleus, and the inferior olivary nucleus of the medulla oblongata. The widespread distribution of NPR-B-immunoreactive structures throughout the monkey brainstem indicates that CNP may be involved in several physiological mechanisms, acting as a neurotransmitter and/or neuromodulator.

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