Immunohistochemical Markers of Clinical Significance in Carcinoma of the Colon and Rectum

Abstract

BACKGROUNDKi-67, a proliferative cell marker has a potential to distinguish rapidly proliferative tumours that are more likely to respond to chemotherapy. The Her2/neu is a marker of prognostic and therapeutic significance that has been in clinical use for breast carcinomas. Similar studies related to other tumours like colorectal carcinomas are needed to explore the significance.The aim of the present study was to analyse the expression of Ki-67 and Her2/neu status in colorectal carcinomas in correlation with parameters like histological type, grade, tumour size and lymph node status.