Immunohistochemical markers of sweat gland tumors

Maiorana, Antonio; Nigrisoli, Evandro; Papotti, Mauro

doi:10.1111/j.1600-0560.1986.tb01644.x

Cited by 55 publications

(22 citation statements)

References 20 publications

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“…[18][19][20][21][22][23] However, other authors have described the findings of decapitation secretion in tubular structures of this neoplasm, which supports an apocrine differentiation, 22,[24][25][26][27] an opinion that we share. 28 In our study, calretinin immunostaining was not found in apocrine hidradenoma, with only focal positivity in the basal layer of some neoplastic aggregations.…”

Section: Discussionmentioning

confidence: 58%

Immunohistochemical Study of Calretinin in Normal Skin and Cutaneous Adnexal Proliferations

González‐Guerra

Kutzner

Rütten

et al. 2012

The American Journal of Dermatopathology

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Calretinin is a calcium-binding protein member of the EF-hand family. The presence of calretinin has been demonstrated in certain stages of the cellular cycle in a wide variety of normal and neoplastic tissues. The main aims of our study were (1) to investigate what structures of the normal skin and cutaneous adnexal proliferations express immunoreactivity for calretinin and (2) to determine the value of immunohistochemical expression for calretinin as a marker for follicular, sebaceous, apocrine, and eccrine differentiation in cutaneous adnexal proliferations. We studied 139 biopsy specimens, including 10 cases of normal skin of different locations and 129 benign and malignant cutaneous adnexal proliferations. In normal skin, we found that calretinin is expressed in the innermost cell layer of the outer root sheath in anagen hair follicle, in both the duct and sebolemma of the sebaceous gland, in the secretory portion of eccrine glands, and in mast cells of the stroma. In cutaneous adnexal proliferations, we found strong immunoreactivity for calretinin in tricholemmal cysts, tricholemmomas/inverted follicular keratoses, tumors of follicular infundibulum, and in some basal cell carcinomas. Focal positivity was also seen in trichoadenomas, trichoblastomas/trichoepitheliomas, pilomatricomas, proliferating tricholemmal tumors, pilar sheath acanthomas, trichofolliculomas, follicular hybrid cysts, cutaneous mixed tumors, steatocystomas, sebaceous hyperplasias, and sebaceomas. These results demonstrate that immunohistochemical study for calretinin may be helpful to identify the innermost cell layer of the outer root sheath in anagen hair follicle and the cutaneous adnexal proliferations showing differentiation toward this structure. Calretinin immunoreactivity supports eccrine differentiation in some sweat gland neoplasms, and it is also useful in identifying neoplasms with ductal sebaceous differentiation.

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Section: Discussionmentioning

confidence: 58%

Immunohistochemical Study of Calretinin in Normal Skin and Cutaneous Adnexal Proliferations

González‐Guerra

Kutzner

Rütten

et al. 2012

The American Journal of Dermatopathology

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“…Since anti-CEA antibody reacts with the inner surface of ductal lumina and intercellular canaliculi of the cccrine gland, this antibody may be used as a marker of the tumor cells differentiating toward the cccrine gland. It has been reported that normal apocrine glandular epithelium [8,10] and apocrine adenocarci noma 1111 arc not stained for CEA. However, these find ings contradict those of other investigators [ 12.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Epithelial Membrane Antigen in Eccrine Poroma

et al. 1991

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Using immunohistochemical methods, we investigated the distribution of epithelial membrane antigen (EMA) on the normal eccrine gland, eccrine poroma and hidroacanthoma simplex. Granular membrane-associated reaction of EMA was detected on the outer cells of both the intraepidermal and the upper portion of intradermal eccrine ducts, as well as on the luminal surfaces and intercellular canaliculi of eccrine glands. Clear immunolabeling was also present in the tumor cells of eccrine poroma and hidroacanthoma simplex. Thus it is suggested that the constituent cells of these tumors originate from the outer cells of the intraepidermal and/or the upper portion of the intradermal eccrine ducts. There was no immunolabeling for EMA on the tumor cells of seborrheic keratosis and basal cell carcinoma. Immunohistochemical staining for EMA is a useful tool for the diagnosis of skin appendage tumors.

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“…However, other authors have not found myoepithelial cells by ultrastuctural and histochemical studies. Furthermore, immunohistochemistry has failed to demonstrate myoepithelial differentiation (6). To clarify the nature of the cells of which is composed, we performed immunohistochemical stainings using various monoclonal antibodies for cytokeratins (CKs: CK, CK7, CK20, Cam5.2), epithelial membrane antigen (EMA), and carcinoembryonic antigen (CEA).…”

Section: Introductionmentioning

confidence: 99%

Giant Vascular Eccrine Spiradenoma: Report of a Case with Immunohistochemical Study

Lee

Moon

et al. 2006

J Korean Med Sci

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We report a rare case of giant vascular eccrine spiradenoma (GVES) which developed in 56-yr-old Korean woman. It is a rare variant of eccrine spiradenoma (ES), which might be mistaken for angiomatous lesions in view of its florid vascularity and hemorrhagic features. Histogenesis of GVES is not clearly elucidated although it is known that ES presumably originates in the eccrine glands. To clarify the histogenesis of GVES, immunohistochemical stainings using various monoclonal antibodies were also performed. The tumor was composed of three types of cells, namely pale epithelial cells, small basal cells, and myoepithelial cells. Therefore, we conclude that GVES originated from eccrine gland and mainly differentiates toward secretory portion of secretory coil.

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Immunohistochemical markers of sweat gland tumors

Cited by 55 publications

References 20 publications

Immunohistochemical Study of Calretinin in Normal Skin and Cutaneous Adnexal Proliferations

Immunohistochemical Study of Calretinin in Normal Skin and Cutaneous Adnexal Proliferations

Distribution of Epithelial Membrane Antigen in Eccrine Poroma

Giant Vascular Eccrine Spiradenoma: Report of a Case with Immunohistochemical Study

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