Immunohistochemical pattern– a prognostic factor for synchronous gastrointestinal cancer

Aliuș, Cătălin; Cîrstoveanu, Cătălin; Badiu, Cristinel Dumitru; Ardeleanu, Valeriu; Dumitru, Vasile Adrian

doi:10.22543/7674.72.p250256

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…The microbiome is different (39)(40)(41), and recently published data has shown that colorectal cancerassociated bacterial clusters are differentially correlated with mucosal gene expression profiles, while a few clusters are associated partially with the expression of pro-inflammatory genes in the mucosa, which may result to colorectal cancer in the future (42). Several molecular and chromosomal differences have been reported (43)(44)(45)(46)(47), while chromosomal instability has been detected in approximately 30% of the right colon cancer and 70% of left colon cancer (48,49). The median age of patients with right colon cancer is higher compared to patients with left colon cancer, while a greater proportion of patients with right colon cancer are females (44,50,51).…”

Section: Discussionmentioning

confidence: 99%

Emergency and Elective Colorectal Cancer – Relationship between Clinical and Biological Factors, Tumor Topography and Surgical Strategies. A Cohort Study

Coman,

Vital,

Coman

et al. 2024

Preprint

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Background and Objectives: The purpose of the study was to analyze the relationships between several clinical and biological factors, but also the tumor topography and surgical strategies used in patients with colorectal cancer. Materials and Methods: We designed an analytical, observational, retrospective study that included patients admitted to our emergency surgical department and diagnosed with colorectal cancer. The study group inclusion criteria were: patients admitted during 2020-2022; patients diagnosed with colorectal cancer (including the ileocecal valve); patients who benefited from a surgical procedure, either in emergency or elective. Results: In our study group, consisting of 153 patients, we accounted for 56.9% male patients and 43.1% female patients. The most common clinical manifestations were pain (73.2% of the study group), followed by abdominal distension (69.3% of the study group) and absence of intestinal transit (38.6% of the study group). A number of 69 patients were operated in emergency (45.1%), while 84 patients (54.9%) benefited from elective surgery. The most frequent topography of the tumor was the sigmoid colon, with 19.60% of the patients, followed by the colorectal junction, with 15.68% of the patients and superior rectum and inferior rectum, with 11.11% of the patients in each subcategory. The most frequent type of procedure was right hemicolectomy (21.6% of the study group), followed by rectosigmoid resection (20.9% of the study group). The surgical procedure was finished by performing an anastomosis in 49% of the patients, an ostomy in 43.1% of the patients, while for 7.8% of the patients, a tumoral biopsy was performed. Conclusions: Colorectal cancer remains one of the most frequent cancers in the world, with a heavy burden that involves high mortality, alterations in the quality of life of the patients and their families, and also the financial costs of the medical systems.

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Section: Discussionmentioning

confidence: 99%

Emergency and Elective Colorectal Cancer – Relationship between Clinical and Biological Factors, Tumor Topography and Surgical Strategies. A Cohort Study

Coman,

Vital,

Coman

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The microbiome is different [ 46 , 47 , 48 ], and recently published data have shown that colorectal cancer-associated bacterial clusters are differentially correlated with mucosal gene expression profiles, while a few clusters are partially associated with the expression of pro-inflammatory genes in the mucosa, which may result in colorectal cancer in the future [ 49 ]. Several molecular and chromosomal differences have been reported [ 50 , 51 , 52 , 53 , 54 ], while chromosomal instability has been detected in approximately 30% of cases of right colon cancer and 70% of cases of left colon cancer [ 55 , 56 ]. The median age of patients with right colon cancer is higher compared to patients with left colon cancer, while a greater proportion of patients with right colon cancer are females [ 51 , 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Emergency and Elective Colorectal Cancer—Relationship between Clinical Factors, Tumor Topography and Surgical Strategies: A Cohort Study

Coman,

Vital,

Coman

et al. 2024

Medicina

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Background and Objectives: The purpose of the study was to analyze the relationships among several clinical factors and also the tumor topography and surgical strategies used in patients with colorectal cancer. Materials and Methods: We designed an analytical, observational, retrospective study that included patients admitted to our emergency surgical department and diagnosed with colorectal cancer. The study group inclusion criteria were: patients admitted during 2020–2022; patients diagnosed with colorectal cancer (including the ileocecal valve); patients who benefited from a surgical procedure, either emergency or elective. Results: In our study group, consisting of 153 patients, we accounted for 56.9% male patients and 43.1% female patients. The most common clinical manifestations were pain (73.2% of the study group), followed by abdominal distension (69.3% of the study group) and absence of intestinal transit (38.6% of the study group). A total of 69 patients had emergency surgery (45.1%), while 84 patients (54.9%) benefited from elective surgery. The most frequent topography of the tumor was the sigmoid colon, with 19.60% of the patients, followed by the colorectal junction, with 15.68% of the patients, and superior rectum and inferior rectum, with 11.11% of the patients in each subcategory. The most frequent type of procedure was right hemicolectomy (21.6% of the study group), followed by rectosigmoid resection (20.9% of the study group). The surgical procedure was finished by performing an anastomosis in 49% of the patients, and an ostomy in 43.1% of the patients, while for 7.8% of the patients, a tumoral biopsy was performed. Conclusions: Colorectal cancer remains one of the most frequent cancers in the world, with a heavy burden that involves high mortality, alterations in the quality of life of patients and their families, and also the financial costs of the medical systems.

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“…Surgical methods frequently offer symptom relief and a better quality of life. Emerging treatments, including cabozantinib, show promise, but the efficacy of targeted treatments on bone health is still under review ( 23 , 24 , 25 , 26 ).…”

Section: Introductionmentioning

confidence: 99%

Practical management of renal cell carcinoma: integrating current approaches with advances in bone metastasis treatment

Eremia,

Serban,

Popa

et al. 2024

EFORT Open Reviews

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Renal cell carcinoma (RCC) is a common type of tumor that can develop in the kidney. It is responsible for around one-third of all cases of neoplasms. RCC manifests itself in a variety of distinct subtypes. The most frequent of which is clear cell RCC, followed by papillary and chromophobe RCC. RCC has the potential for metastasis to a variety of organs; nevertheless, bone metastases are one of the most common and potentially fatal complications. These bone metastases are characterized by osteolytic lesions that can result in pathological fractures, hypercalcemia, and other complications, which can ultimately lead to a deterioration in quality of life and an increase morbidity. While nephrectomy remains a foundational treatment for RCC, emerging evidence suggests that targeted therapies, including tyrosine kinase inhibitors and T cell checkpoint inhibitors, may offer effective alternatives, potentially obviating the need for adjuvant nephrectomy in certain cases of metastatic RCC Bone metastases continue to be a difficult complication of RCC, which is why more research is required to enhance patient outcome.

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Immunohistochemical pattern– a prognostic factor for synchronous gastrointestinal cancer

Cited by 4 publications

References 21 publications

Emergency and Elective Colorectal Cancer – Relationship between Clinical and Biological Factors, Tumor Topography and Surgical Strategies. A Cohort Study

Emergency and Elective Colorectal Cancer – Relationship between Clinical and Biological Factors, Tumor Topography and Surgical Strategies. A Cohort Study

Emergency and Elective Colorectal Cancer—Relationship between Clinical Factors, Tumor Topography and Surgical Strategies: A Cohort Study

Practical management of renal cell carcinoma: integrating current approaches with advances in bone metastasis treatment

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