Immunohistochemical properties of embryonic telocytes in a myogenic microenvironment

Abstract

Telocytes are a unique interstitial cell type that functions in adulthood and embryogenesis. They have characteristic immunohistochemical phenotypes while acquiring different immunohistochemical properties related to the organ microenvironment. The present study aims to investigate the immunohistochemical features of embryonic telocytes during myogenesis and describe their morphology using light microscopy and TEM. Telocytes represent a major cellular constituent in the interstitial elements. They had distinguished telopodes and podoms and formed a 3D interstitial network in the developing muscles. They formed heterocellular contact with myoblasts and nascent myotubes. Telocytes also had distinctive secretory activity. Telocytes identified by CD34. They also express CD68 and MMP-9 to facilitate the development of new tissues. Expression of CD21 by telocytes may reveal their function in immune defense. They also express VEGF, which regulates angiogenesis. In conclusion, the distribution and immunological properties of telocytes in the myogenic tissue indicate that telocytes provide biological and structural support in the development of the myogenic tissue architecture and organization.

Immunohistochemical-properties of the dermal embryonic telocytes

“…The structural profile of telocytes enables cellular contact through their telopodes, or cell prolongations, which can grow to be hundreds of microns long. Telopodes are made up of dilated segments called podoms and thin segments called podomers, where the endoplasmic reticulum and mitochondria are grouped together 1 , 2 .…”