1997
DOI: 10.1177/002215549704500610
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Immunohistochemical Similarities and Differences between Amelogenin and Tuftelin Gene Products During Tooth Development

Abstract: SUMMARYAmelogenins and tuftelins are highly specialized proteins secreted into the developing enamel matrix during mammalian enamel formation. Both tuftelins and amelogenins have been associated with various functions during nucleation and maturation of the developing enamel matrix. In this study we conducted experiments to investigate whether tuftelins and portions of the amelogenin molecule were deposited and processed in spatially distinguished portions of the developing enamel matrix, using antibodies spec… Show more

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Cited by 43 publications
(22 citation statements)
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“…Although some of these recently identified enamel proteins have been localized in tissues outside of teeth, they might be of relevance to the mechanisms of enamel formation (Deutsch et al, 1991;ZeichnerDavid et al, 1995ZeichnerDavid et al, , 1997MacDougall et al, 1998). Tuftelin, the nonamelogenin enamel protein investigated in this study, has been sequenced and characterized (Deutsch, 1989;Deutsch et al, 1991;ZeichnerDavid et al, 1995ZeichnerDavid et al, , 1997Diekwisch et al, 1997;Mao et al, 2001;Satchell et al, 2002).…”
Section: Enamel Proteinsmentioning
confidence: 84%
“…Although some of these recently identified enamel proteins have been localized in tissues outside of teeth, they might be of relevance to the mechanisms of enamel formation (Deutsch et al, 1991;ZeichnerDavid et al, 1995ZeichnerDavid et al, , 1997MacDougall et al, 1998). Tuftelin, the nonamelogenin enamel protein investigated in this study, has been sequenced and characterized (Deutsch, 1989;Deutsch et al, 1991;ZeichnerDavid et al, 1995ZeichnerDavid et al, , 1997Diekwisch et al, 1997;Mao et al, 2001;Satchell et al, 2002).…”
Section: Enamel Proteinsmentioning
confidence: 84%
“…We used antibodies directed against laminin ␣2 (4H8 -2, Alexis) (12), ameloblastin (AMBN) (17), amelogenin (AMEL) (18,19), and DSP (20) (provided by Yoshihiko Yamada). The primary antibodies were detected using fluorescein isothiocyanate or Cy-3-conjugated secondary antibodies (Jackson ImmunoResearch).…”
Section: Methodsmentioning
confidence: 99%
“…Amelogenins are essential to the proper regulation of enamel mineralization. Amelogenin expression is ameloblast-specific and developmentally regulated at the temporal and spatial levels (1)(2)(3)(4)(5)(6)(7)(8). A 2263-nucleotide proximal promoter element from the mouse X-chromosomal amelogenin gene has been demonstrated by transgenic mouse analysis to direct the expression of a reporter gene in a temporal and spatial pattern that is essentially identical to that of the endogenous amelogenin gene (5).…”
mentioning
confidence: 99%