Immunohistochemical studies of keratin distribution in salivary gland tumors.

Mori, Masahiko; Murase, Noriyasu; Hyun, Kyung Hwa; Sumitomo, Shinichiro; Kawamura, Kazutaka

doi:10.1267/ahc.18.21

Cited by 27 publications

(10 citation statements)

References 19 publications

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“…Microfilaments are composed of actin, filamin and myosin and they participate in cellular mobility (14,17,27,29). Ductal epithelia of intercalated (ICD), striated (SD), and excretory duct (ED) have been noted to contain abundant keratin polypeptides in human salivary glands as well as mammalian specimens (4,7,22,30,33,34) . A preceding paper has described that the vimentin class of filament proteins specifically exists in hamster granular convoluted tubule (GCT) cells of the submandibular gland (SMG) (24) .…”

mentioning

confidence: 99%

Immunohistochemical evaluation of different filament proteins in human salivary glands.

Hosaka

Tatemoto

Yamagami

et al. 1985

Acta Histochem. Cytochem

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confidence: 99%

Immunohistochemical evaluation of different filament proteins in human salivary glands.

Hosaka

Tatemoto

Yamagami

et al. 1985

Acta Histochem. Cytochem

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“…This pattern may indicate the keratinization process or squamous differentiation occurring at the luminal surface of duct-like epithelial structures. In similar specimens, immunohistochemically detectable keratin proteins are found in all cells located on the luminal side of tubular and duct-like structures (2,3).…”

Section: Discussionmentioning

confidence: 88%

“…In the present study, ductal epithelia and acinar cells, either serous or mucous, of normal glands indicated negative staining as did duct-like structures in obstructive sialadenitis. Keratin staining is strongly evident in epithelial architecture, i.e., normal ductal segments of salivary glands and duct-like structures of sialadenitis (2,3,6,12). This finding suggests that the duct-like structures in obstructive salivary lesions have less tendency to terminal keratinization.…”

Section: Discussionmentioning

confidence: 89%

Expression of involucrin in human salivary gland lesions and tumors.

Sumitomo

Kumasa

Iwai

et al. 1986

Acta Histochem. Cytochem

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“…Distribution of cytokeratins has been studied in humans and in laboratory animals. They have been detected in ductal segments of the submandibular glands in human [6] and rat [7]. Furthermore, cells from the excretory ducts of the rat pancreas including the centroacinar cells (CACs) showed immunopositive reaction for different cytokeratins antibodies [8,9].…”

Section: Introductionmentioning

confidence: 99%

Detection of an Intermediate Filament Protein in the Pancreas and Mandibular Salivary Gland of the Goat (Capra hircus): An Immunocytochemical Study

Elewa¹,

Elsayed²,

Mohamed³

et al. 2017

J Vet Sci Technol

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The centroacinar cells (CACs) are a specialized ductal pancreatic cell. Recently, it has been revealed that such cells showed a progenitor function in the pancreas of adult mouse and zebrafish. However, no information about its occurrence in other exocrine glands specially in farm animals. Cytokeratins immunohistochemistry was used to detect ductal segments of the submandibular glands and the pancreas including CACs in human and rat. In the present study, the detection of cytokeratins in the normal goat pancreas (a serous type gland) and mandibular salivary gland (a mixed type gland, consisted of mucous tubules capped with serous demilunes) was investigated using a standard immunoperoxidase technique on paraffin sections. In the goat pancreas and mandibular salivary gland, cytokeratins were found in all duct cells including the CACs of the pancreas. Interestingly in the mandibular salivary glands, some immunoreacted cells with immunopositive cytoplasmic extensions were frequently observed between the cytoplasm of the mucous cells, especially near the lumina of the mucous tubules. We postulate that these cells could be centroacinar-like cells. Therefore, from these findings, it can be concluded that these cells could provide a supportive cytoskeleton to maintain cellular shape and avoid the collapse of the mucous cells during mucous secretion. Additionally, a regenerative function for such cells could be hypothesized. Furthermore, the keratin demonstration could be used as a marker for ductal cells and is a useful aid in the detection of lesions derived from gland ductal cells in goat. Further research is necessary to investigate the expression of keratins in caprine glandular tumors as well as the regenerative ability of these centroacinar-like cells in goat mandibular salivary glands injury.

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Immunohistochemical studies of keratin distribution in salivary gland tumors.

Cited by 27 publications

References 19 publications

Immunohistochemical evaluation of different filament proteins in human salivary glands.

Immunohistochemical evaluation of different filament proteins in human salivary glands.

Expression of involucrin in human salivary gland lesions and tumors.

Detection of an Intermediate Filament Protein in the Pancreas and Mandibular Salivary Gland of the Goat (Capra hircus): An Immunocytochemical Study

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