Immunohistochemical Study of Porokeratotic Eccrine Nevus

Soloeta, R.; Yanguas, I.; Lozano, M; González-Güemes, Magdalena; Goday, J.J.

doi:10.1111/j.1365-4362.1996.tb05057.x

Cited by 15 publications

(10 citation statements)

References 14 publications

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“…Punctate porokeratosis is a rare, often congenital variant of porokeratosis which may be clinically indistinguishable from PEODDN. Although punctate porokeratosis is characterized by cornoid lamellation which may involve the sweat gland ostium, hair follicles, or interadnexal epidermis, there are no comedo-like epidermal invaginations (4). PEODDN is characterized by comedo-like epidermal invaginations surrounding cornoid lamellae that emerge exclusively from eccrine ostia.…”

Section: Discussionmentioning

confidence: 99%

Keratotic Papules on the Palm of a 12‐Year‐Old Boy

Warren

Baselga

Fleming

et al. 1998

Pediatric Dermatology

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A 12-year-old boy was referred to our pediatric dermatology clinic for evaluation of skin lesions on his left palm (Fig. 1). The lesions were asymptomatic and had been present since birth. The child was otherwise in excellent general health. His medical and family histories were unremarkable.Physical examination revealed a linear arrangement of 1 to 2 mm brown, discrete keratotic papules on the left palm. Many of the larger papules were crateriform with a central filiform spicule (Fig. 2). After heat-induced sweating, focal anhidrosis was not demonstrated in the involved area by the starch-iodine technique.A biopsy specimen of lesional skin was obtained and stained with hematoxylin and eosin (Fig. 3) and with an antibody to carcinoembryonic antigen (CEA) (Fig. 4). Figure 1. Keratotic crateriform papules on the left palm.

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Section: Discussionmentioning

confidence: 99%

Keratotic Papules on the Palm of a 12‐Year‐Old Boy

Warren

Baselga

Fleming

et al. 1998

Pediatric Dermatology

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“…[2] In recent years, immunohistochemistry with CEA staining the cuticle of the acrosyringium and dermal duct traversing the parakeratotic column but not the inner borders of the epidermal invagination, supports the theory that it represents an abnormally keratinizing epidermal invagination through which an acrosyryngium traverses. [1,5,6] Wang et al, [1] have demonstrated that abnormal keratinizing epidermal invagination may be due to increased proliferation as shown by keratin (Ki-67) staining at the basal layer underneath the cornoid lamella.…”

Section: Case Reportmentioning

confidence: 98%

Porokeratotic eccrine ostial and dermal duct nevus

Pathak¹,

Kubba²,

Kubba³

2011

Indian J Dermatol Venereol Leprol

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Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare variant of porokeratosis with characteristic histological feature of cornoid lamella involving the acrosyringium. We report a classic case of a 20-year-old male, who clinically presented to us with keratotic papules and plaque with pits, few having comedo like plugs, on right palm and sole since 1 year of age. A punch biopsy from palm was diagnostic as well as confirmatory showing cornoid lamella involving an eccrine duct which is the characteristic histopathological feature of PEODDN.

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“…Most patients have relatively localized involvement of an acral site, with 24 of 39 reported cases involving the palms/hands, soles/feet, or both. 1,2,5,7,9,10,13,14,16,18,19,22,27,28,30,[32][33][34][35][36][37][38][39][40][41] The vast majority of PEODDN case reports (32 of 39) describe unilateral involvement, with 7 having bilateral distribution. 6 involving the proximal extremities, trunk, buttocks, neck, or a combination of these has been reported in 13 of 39 cases of PEODDN.…”

Section: Clinical Findingsmentioning

confidence: 99%

“…There have been two prior reports of PEHFN 3,4. Of the 39 total cases of PEODDN, 2 had onset of the disease at birth,1,[5][6][7][8][9]11,13,14,16,18,21,23,24,26, 29-31,33,34,36,39,41 6 had onset in the first few years of life…”

mentioning

confidence: 94%