Immunohistochemical study of TGF-β, PDL-1, and IL-10 in patients with Toxoplasma gondii

Alsailawi, HA; Ayat, None SS; Mudhafar, Mustafa; Mohammed, None Ruaa K; Dhahi, None Sahi J; Abdulrasool, None MM; Shawkat, Shahad; Raheem, None Hussein A.

doi:10.30574/wjarr.2022.14.1.0346

Cited by 3 publications

(2 citation statements)

References 62 publications

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“…The results of this study suggest that the degree of coronary heart disease (CHD) may be related to the betatrophin, ANGPTL4, LPL pathway. Furthermore, the results showed that LPL and ANGPTL3 levels increased in people with CHD diagnoses, and the rising trends observed for both of these markers were consistent with the findings reported in (16). The functional difference between members of the ANGPTL family is attributed to the variation between their C-terminal and N-terminal domains, as demonstrated by the results of previous studies.…”

Section: Discussionsupporting

confidence: 88%

Study the Relations Between Angiopoietin-Like Protein 4 (Angptl4) and Lipoprotein Lipase as Predictors for Ischemic Heart Disease in Patients With T2dm

Ahmed ABASS,

Ridha SHIHAN,

Sabbar OMRAN

2024

MINAR Journal

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Betatrophin production and blood lipid profile have been proven in previous research to have a correlation, both in the laboratory and in clinical settings. Investigations on the connection and contact behavior of lipoprotein lipase, betatrophin, and angiogenin- likeprotein3 (ANGPTL3) continue to vary from one another (LPL). This study aimed to evaluating the relationship between betatrophin, ANGPTL4, and LPL in addition to the severity of IHD in individuals with diabetes. There were sixty people with diabetes in the case group (30 with IHD and 30 without IHD). The control group included thirty people in total. While the serum concentration of ANGPTL4 was assessed using a double antibody sandwich ELISA, the serum concentrations of betatrophin, LPL, and ANGPTL4 were assessed using the enzyme-linked immunosorbent assay (ELISA). The levels of total cholesterol, fasting blood glucose, and triglycerides in each group were determined using an automated biochemical analyzer. The clinical baseline data for each patient group was incorporated into the analysis within the same time frame. Consequently, compared to diabetic patients without IHD and those in the control group, individuals with IHD had significantly higher levels of betatrophin, ANGPTL4 and LPL (p 0.05). With diabetic patients with IHD, the Gensini rating significantly and favorably correlated with TC, TG, LDL-C, betatrophin, LPL, and BMI (r = 0.201, 0.501, 0.045, 0.562, 0.611, and 0.431 and P = 0.041, 0.008, 0.038, 0.009, 0.002, and 0.039 respectively) In all groups of gensini score with (P<0.05), there is a statistically significant difference found in the levels of betatrophin, ANGPTL4, and LPL. In patients with diabetes, the degree of IHD was associated with the betatrophin, ANGPTL4, and LPL parameters.

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Section: Discussionsupporting

confidence: 88%

Study the Relations Between Angiopoietin-Like Protein 4 (Angptl4) and Lipoprotein Lipase as Predictors for Ischemic Heart Disease in Patients With T2dm

Ahmed ABASS,

Ridha SHIHAN,

Sabbar OMRAN

2024

MINAR Journal

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“…These methods (in comparison to other analytical methods) are characterized by sensitivity and tuning, as well as selectivity ranging from good to medium, and are quick and low-cost, with the ability to analyse both organic and inorganic compounds (5). In the last decade, the importance of these approaches has risen dramatically in terms of the construction of equipment and methods for sample preparation (6). Spectroscopy methods are used in the pharmaceutical study of any medication to determine the drug's structure and how it interacts with the other ingredients in the preparation (7).…”

Section: Spectrophotometric Methods Of Analysismentioning

confidence: 99%

Determination of trace amount of some drugs as in its pure form and in its Pharmaceutical Preparations by using different spectroscopic methods

kadhim¹,

Alsailawi²,

Mudhafar³

et al. 2023

World J. Adv. Res. Rev.

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The present study includes analytical methods for determination of the drugs Chlorpromazine hydrochloride (CPZ) and trifluoperazine hydrochloride (TFPH) in some pharmaceuticals using molecular absorption, indirect AAS, in addition to investigating complexes obtained throughout. Chlorpromazine hydrochloride and trifluoperazine hydrochloride are widely used for the treatment of schizophrenia. Synthetic formulas for the prepared drug complexes were proposed through the results of the molar ratios of the combination between the drug and each of copper, lead, chrome and iron.

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Toxoplasma Gondii Seroprevalence Among Pregnant Women in Baghdad During 2021-2022

Hamza¹,

Hameed

Al-Zubaidi³

et al. 2022

J Obstet Gynecol Cancer Res

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Background & Objective: Toxoplasmosis is a zoonotic infection caused by Toxoplasma gondii, a parasite that causes a variety of clinical symptoms in humans. It is a facultatively heteroxenous, polyxenous protozoon that has evolved several potential transmission routes within and between the host species. Infections caused by Toxoplasma gondii are more frequently seen in immunocompetent patients. The infection acquired by the mother during pregnancy puts the fetus at risk of congenital infection due to the parasite transmission across the placenta. The severity and frequency of infection are determined by the gestational age of the mother at the time of infection. The objective of this research was to study the toxoplasmosis infection in women, and to estimate the relationship between T. gondii infection and parameters including abortion time, chronic diseases, and age. Materials & Methods:The case-control study was conducted on 50 healthy women (pregnant and non-pregnant) as control group and 135 women with abortion experience as case group at the Women's and Children's Hospital in Baghdad, Iraq from December 2021 until March 2022. The questionnaire was used to gather information from the women. The participant's name, age, gestational age, address, medications taken, medical history, previous abortions, and the date the sample was taken were all included. Under sterile conditions, five milliliters of the venous blood were drawn from each woman. The ELISA test was used to determine the level of anti-T. gondii IgM and IgG antibodies in serum samples. Results:The anti-Toxoplasma IgM and IgG antibodies were found to be positive in 51% and 8% of the cases, respectively. However, the anti-T. gondii antibodies seroprevalence was 59% in women who had abortion. The healthy women had 0% for all antibodies. Conclusion:Despite reporting the high rates of infection among women who had single abortions, the current study found no significant association between the percentage of infection and the number of abortions. The cause of high incidence among women who had abortion could be due to decrease in the immune system function.

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Immunohistochemical study of TGF-β, PDL-1, and IL-10 in patients with Toxoplasma gondii

Cited by 3 publications

References 62 publications

Study the Relations Between Angiopoietin-Like Protein 4 (Angptl4) and Lipoprotein Lipase as Predictors for Ischemic Heart Disease in Patients With T2dm

Study the Relations Between Angiopoietin-Like Protein 4 (Angptl4) and Lipoprotein Lipase as Predictors for Ischemic Heart Disease in Patients With T2dm

Determination of trace amount of some drugs as in its pure form and in its Pharmaceutical Preparations by using different spectroscopic methods

Toxoplasma Gondii Seroprevalence Among Pregnant Women in Baghdad During 2021-2022

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