Immunohistochemical Study on Cutaneous B Cell Lymphoma in Two Cows

Anjiki, Takashi; Kagawa, Yuuichi; Ishikawa, Yoshiharu; Kadota, Koichi

doi:10.6090/jarq.43.33

Cited by 6 publications

(6 citation statements)

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“…Similar to the reports for pleomorphic B cell lymphoma 1,9,13. , in this study the main cytological findings from cases 1-16 were pleomorphism and atypia, which are not so prominent in other histological types of lymphoid neoplasms 1,2,[6][7][8][9][10]13,14,17,18 . Such features were considered characteristic of the majority of lymphoma cases truly associated with BLV.…”

Section: Discussionmentioning

confidence: 99%

“…These classifications are based on the cell size and/or nuclear cleavage and fail to distinguish between BLV-positive and negative cases. In contrast, some cases of BLV-positive lymphoma, which were diagnosed as pleomorphic B cell lymphoma based on pleomorphism and atypia 1,9.13 , were cytologically distinct from other lymphoid malignancies 1,2,[6][7][8][9][10]13,14,17,18 . In this paper, we describe the histology and immunohistochemistry of B cell lymphomas in 17 cows having tested positive for BLV by nested polymerase chain reaction (PCR).…”

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confidence: 99%

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Cytology of B Cell Lymphomas in Cattle Infected with Bovine Leukosis Virus

Iwama

Inomata

Ishikawa

et al. 2013

JARQ

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Lymphoid neoplasms in 17 cattle having tested positive for bovine leukosis virus (BLV) were investigated by histology and immunohistochemistry. In 16 cases, the neoplastic cells were characterized by a marked variation in cell size, atypia in large cells, nuclear irregularity in smaller cells, and nucleolar prominence in cells with scant cytoplasm. These cytological features were used to specifically define pleomorphic lymphomas. In addition to lymphoid cells, immunoblastoid and plasmacytoid cells containing cytoplasmic immunoglobulin G were observed in the remaining case. Since a similar case was recorded as lymphoplasmacytoid lymphoma in a BLV-negative cow, this polymorphic case may not be related to the virus. Most lymphoma cases associated with BLV are classified as pleomorphic, and neoplasms termed enzootic leukosis should be diagnosed based on tumor cell morphology.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Cytology of B Cell Lymphomas in Cattle Infected with Bovine Leukosis Virus

Iwama

Inomata

Ishikawa

et al. 2013

JARQ

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“…The T-cell type is referred to as epitheliotropic and may be CD4-or CD8-positive, resembling MF or WC1 positive gdT-cell lymphoma. The B-cell type, unrelated to BLV infection, is a rare, non-epitheliotropic type of cutaneous lymphosarcoma that affects cattle (Buczinski et al 2006;Anjiki et al 2009). In the present case, the CD3-positive and CD79αcy-negative reactions in the cytoplasm of neoplastic cells allowed us to identify whether a tumour was of T-cell origin.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical profile of multicentric cutaneous epitheliotropic T-cell lymphoma with generalised lymphadenopathy in a Holstein-Friesian cow: a case report

Otrocka-Domagała¹,

Procajło²,

Pazdzior³

et al. 2012

Vet. Med. - Czech

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ABSTRACT:Cutaneous epitheliotropic T-cell lymphoma with progression to superficial and internal lymph nodes and the spleen was diagnosed in a two-year-old Holstein-Friesian cow. The skin lesions included multiple hypotrichous to alopecic nodules, often with ulceration, which first appeared three months after calving and progressed quickly to cover the entire body. The cow was euthanized one month later. The ELISA test excluded bovine leukaemia virus infection. Histologically in the epidermis, the formation of Pautrier's microabscesses and in the dermis, dense neoplastic infiltration with mild folliculotropism was observed. Similar neoplastic cells were present in the histological sections of lymph nodes and spleen. Immunohistochemical analysis was performed using CD3, CD79αcy, HLA-DR, WC1-N3 and Ki67 antibodies. Immunophenotyping results (CD79αcy-, CD3+, WC1-N3-) confirmed the αβ T-cell origin of neoplastic cells. The mean Ki67 index among neoplastic cells was 15.3%. On the basis of the immunohistochemical and histopathological results, the first case in Poland of cutaneous epitheliotropic T-cell lymphoma in a cow was confirmed. Additionally, MHC class II expression on approximately 10.4% of lymphoma cells was associated with a poor clinical prognosis. However, the up-regulation of MHC class II expression on accompanying cells suggested tumour immune surveillance, an antigen-specific immune response or immunosuppression. However, further investigations are needed to confirm these suspicions.

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“…T cell malignancies such as precursor T lymphoblastic leukemia 7 and γδ T cell lymphoma 1 have been reported in BLV-infected cattle, and were thought to have no relation to the virus 5 . Sporadic lymphoid neoplasms are divisible into calf, thymic, and cutaneous forms, but more than one disease entity is included in each form 2,6,7,12,16,17,19 . Taking into account the large population of normal hematopoietic cells in the bone marrow, a fair number of myeloid leukemias must occur in cattle.…”

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confidence: 99%

Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

Murayama

Sato

Ikehata

et al. 2011

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Ten cases of bovine lymphohematopoietic neoplasms were investigated histologically, histochemically, and immunohistochemically, and were classified into eight histologic types on the basis of the origin and morphology of tumor cells. Case 1, a precursor B lymphoblastic leukemia, was positive for CD79a and terminal deoxynucleotidyl transferase. Case 2, a thymic B cell lymphoma, was also positive for these markers, but there were cytologic differences between the two cases. Cases 3-5 were diagnosed as pleomorphic B cell lymphomas, which were characterized by cytologic pleomorphism and expression of CD79a and CD5, and were etiologically associated with bovine leukosis virus (BLV). A case of diffuse large B cell lymphoma of the cerebrum (case 6) also showed a positive result for CD79a and CD5. However, the lymphoma was composed of a homogeneous population of large neoplastic cells, and was considered to be unrelated to BLV. The other B cell cases were categorized into immunoblastic (case 7) and lymphoplasmacytic (case 8) lymphomas, in which immunoglobulin-producing lymphoma cells were observed. In a cutaneous γδ T cell lymphoma (case 9), the neoplastic cells cytologically resembled those in case 6, but expressed CD3 and WC1. In case 10, an acute basophilic leukemia, some leukemia cells had intracytoplasmic granules that were metachromatic and tryptase positive but negative for naphthol AS-D chloroacetate esterase. Bovine lymphohematopoietic malignancies are classifiable into discrete histologic types according to immunophenotype. The classification is more scientific than the traditional one, the latter being based on the age of affected animals and/or the site of tumor formation.

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Immunohistochemical Study on Cutaneous B Cell Lymphoma in Two Cows

Cited by 6 publications

References 7 publications

Cytology of B Cell Lymphomas in Cattle Infected with Bovine Leukosis Virus

Cytology of B Cell Lymphomas in Cattle Infected with Bovine Leukosis Virus

Immunohistochemical profile of multicentric cutaneous epitheliotropic T-cell lymphoma with generalised lymphadenopathy in a Holstein-Friesian cow: a case report

Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

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