Immunohistochemistry

Azumi, Norio; Czernobilsky, Bernard

doi:10.1007/978-1-4757-3889-6_26

Cited by 6 publications

(4 citation statements)

References 163 publications

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“…Normal cells have low levels of wild-type p53 that are undetectable by current immunohistochemical methods. De-ACKNOWLEDGMENTS tectable p53 is found only in malignant cells [8,18].…”

Section: P53 In Endometrial Cancermentioning

confidence: 99%

p53 as a Prognostic Indicator in Endometrial Cancer

Geisler

Wiemann

Zhou

et al. 1996

Gynecologic Oncology

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“…Normal cells have low levels of wild-type p53 that are undetectable by current immunohistochemical methods. De-ACKNOWLEDGMENTS tectable p53 is found only in malignant cells [8,18].…”

Section: P53 In Endometrial Cancermentioning

confidence: 99%

p53 as a Prognostic Indicator in Endometrial Cancer

Geisler

Wiemann

Zhou

et al. 1996

Gynecologic Oncology

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“…Although glandular differentiation was not apparent in our case by conventional histological examination, we speculated that it could be minimal and visible only at the immunohistochemical level. Therefore, we performed immunostains which could support mullerian-type differentiation, such as ER, PR, CK7, and CA125 [ 17 ]. ER and PR were negative, and CK7 and CA125 were positive in only a few cells.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Basaloid Carcinoma with Shadow Cell Differentiation

Zámečnı́k¹,

Jando²,

Kaščák

2014

Case Reports in Pathology

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So-called shadow cell differentiation (SCD) is typical for pilomatrixoma and other skin lesions with follicular differentiation, but it was rarely described also in some visceral carcinomas. We report a case of ovarian basaloid carcinoma with SCD. The tumor presented as a 14 cm ovarian mass in a 45-year-old woman, and therefore the adnexectomy and hysterectomy were performed. The tumor was of high stage. Multiple metastases were found in the liver, retroperitoneal and mediastinal lymph nodes, and the lung. Histologically, the tumor showed a pattern of high-grade basaloid carcinoma with numerous shadow cells. Extensive histologic examination did not reveal any glandular or preexisting teratoma component. Immunohistochemically, the tumor expressed markers of squamous cell differentiation, such as p63, cytokeratin 5/6, and high-molecular-weight keratin. Cytokeratin 7 and CA125 were positive in scattered cells of the lesion. Estrogen and progesterone receptor, vimentin, and p53 were negative. Beta-catenin showed nuclear and cytoplasmic positivity, indicating possible tumor proliferation/differentiation via Wnt signaling pathway. To our knowledge, SCD in basaloid carcinoma of the ovary was not described before. In addition to the description of the case, we review the literature on SCD in visceral carcinomas.

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“…The occasional presence of β‐hCG‐positive cells in conventional lung cancer, especially in large cell carcinoma, has been reported 47 . Moreover, expression of PLAP on immunohistochemistry, may be found in normal and neoplastic bronchial tissues containing placental‐like alkaline phosphatase 48 . However, these dedifferentiated carcinomatous cells that were positive for β‐hCG and PLAP near the choriocarcinoma were histologically indistinguishable from those that were positive for EMA and SP‐A near the conventional adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary choriocarcinoma combined with adenocarcinoma

Yamamoto¹,

Tanaka

Takeo³

et al. 2006

Pathology International

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An extremely rare autopsy case of primary pulmonary choriocarcinoma combined with adenocarcinomatous components in a 77-year-old Japanese man is described. The patient died of rapidly progressive respiratory dysfunction without ante-mortem diagnosis. Autopsy revealed necro-hemorrhagic areas of the primary lung tumor with a typical biphasic pattern of choriocarcinoma. Topographical analysis suggested that moderately to poorly differentiated adenocarcinoma components partially surrounded the choriocarcinomatous components. Moreover, dedifferentiated carcinomatous components were scattered next to both adenocarcinomatous and choriocarcinomatous areas, and a few cells of the dedifferentiated carcinomatous components had a similar immunoreaction to conventional adenocarcinomatous or choriocarcinomatous components, such as surfactant apoprotein A, placental alkaline phosphatase or beta-human chorionic gonadotropin. Additionally, epithelial membrane antigen-positive cytotrophoblastic cells were rarely found in choriocarcinomatous areas. The present case suggests that primary lung choriocarcinoma can occur closely related to conventional pulmonary adenocarcinoma, although collision tumor was not completely ruled out.

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Immunohistochemistry

Cited by 6 publications

References 163 publications

p53 as a Prognostic Indicator in Endometrial Cancer

p53 as a Prognostic Indicator in Endometrial Cancer

Ovarian Basaloid Carcinoma with Shadow Cell Differentiation

Primary pulmonary choriocarcinoma combined with adenocarcinoma

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