Immunohistological Diagnosis of Primary Brain Lymphoma Using Monoclonal Antibodies: Confirmation of B—Cell Origin

Garson, Jeremy A.; Bourne, S. P.; Allan, Patricia; Leather, C.; Brownell, Daniel; Coakham, Hugh B.

doi:10.1111/j.1365-2990.1988.tb00863.x

Cited by 12 publications

(1 citation statement)

References 34 publications

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“…The recent demonstration by Bashir [60] of specific immunophenotypes for NHL-CNS cells argues that these cells may be B cells of a subspecies separable from those of systemic lymphoma and non tumor B cell populations. Similarly Garson [61] demonstrated the unusual B cell nature of NHL CNS by the identification of the presence of B-1 (CD 20 antigen) and FMC7 markers in 7 of 20 populations tested. That these cells were arrested at a mature stage was supported by similar work by Smith [62].…”

Section: Newer Approachesmentioning

confidence: 99%

The therapy of primary brain lymphoma

Hochberg

Loeffler²,

Prados

1991

J Neuro-Oncol

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Recommendations regarding the current therapy of primary brain lymphoma (NHL-CNS) take into account the occurrence of this tumor in immunocompetent and immunosuppressed hosts. Immunohistochemical evaluation of biopsy material or spinal fluid provides the diagnosis in 90% of patients. For the immunocompetent, pre-irradiation intra-venous or intra-arterial chemotherapy with Methotrexate alone or in combination with other agents is provided to treat tumor within multiple brain sites. Subarachnoid deposits are treated with Methotrexate by intrathecal administration. Radiation is provided after chemotherapy and for the treatment of vitreal/retinal deposits or symptomatic lesions within the spinal axis. The therapy of recurrent NHL-CNS makes use of intravenous Methotrexate or high dose Cytosine Arabinoside. Immunosuppressed patients respond to reduction of immunosuppressive medication. The therapy of NHL-CNS in the AIDS patient makes use of corticosteroids followed by cranial irradiation. A discussion of emerging trends in the therapy of NHL-CNS in the AIDS and non-AIDS population is provided.

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Section: Newer Approachesmentioning

confidence: 99%

The therapy of primary brain lymphoma

Hochberg

Loeffler²,

Prados

1991

J Neuro-Oncol

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Neuropathology of AIDS

Artigas¹,

Grosse²,

Niedobitek³

1993

The Central Nervous System in AIDS

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Non-Hodgkin's lymphoma involving the brain

et al. 1989

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A stereotactic needle biopsy was examined for applicability in diagnosing brain non-Hodgkin's lymphoma (NHL), because the procedure is far less aggressive than biopsy by open surgery. Formalin-fixed materials including four stereotactic specimens were available from nine patients with brain NHL. In addition to routine histopathology and histochemistry, paraffin-section immunohistochemistry was performed using a panel of monoclonal antibodies suited to such sections. Although several histopathological features characteristic of brain NHL could not be evaluated in three of the four stereotactic specimens owing to the small size of the specimens and partial invasion by lymphoma cells, the lesions in all cases could be characterised by immunohistochemistry. Examination for cytoplasmic immunoglobulin (cIg) was also performed, but specific identification of cIg was difficult in five cases because of diffuse background staining and passive diffusion of plasma protein into the cells during tissue processing. A review of the literature indicates the technical difficulty in cIg staining, since the incidence of cIg-positive cases in an individual study varied considerably, and lymphoma cells in 15 of 128 cIg-positive brain NHL cases have been reported to possess both light chains. From these findings, together with the relative difficulty in obtaining fresh tissues for study, it is concluded that, when the specimens are to be examined by paraffin-section immunohistochemistry using the above monoclonal antibodies, stereotactic needle biopsy is a useful, less aggressive method for diagnosing brain NHL.

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Immunohistological Diagnosis of Primary Brain Lymphoma Using Monoclonal Antibodies: Confirmation of B—Cell Origin

Cited by 12 publications

References 34 publications

The therapy of primary brain lymphoma

The therapy of primary brain lymphoma

Neuropathology of AIDS

Non-Hodgkin's lymphoma involving the brain

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