Immunohistological study of intervertebral disc herniation of lumbar spine

Arai, Yoshiaki; Yasuma, Tsuguo; Shitoto, Katsuo; Yamauchi, Yasuo; Suzuki, Fujihiko

doi:10.1007/s007760050156

Cited by 38 publications

(31 citation statements)

References 9 publications

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“…Slavin et al hypothesized [23] that cartilaginous tissue resorption results from enzymatic degradation and phagocytosis as a result of inflammation and neovascularization due to an autoimmune response [24,25]. Some studies have revealed neovascularization at the periphery of the sequestrated disc and the presence of macrophages and T cells in the vascularized areas [26][27][28]. In our study, all patients with reduced pseudotumors demonstrated contrast enhancement of their pseudotumor on MRI after Gd administration.…”

Section: Discussionsupporting

confidence: 57%

C1 laminectomy for retro-odontoid pseudotumor without atlantoaxial subluxation: review of seven consecutive cases

et al. 2013

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Purpose A retro-odontoid pseudotumor is usually a reactive fibrocartilaginous mass associated with atlantoaxial subluxation (AAS). However, a retro-odontoid pseudotumor not associated with AAS, which undergoes spontaneous regression following C1 laminoplasty, has been reported. The purpose of this study was to report surgical outcomes of C1 laminectomy for retro-odontoid pseudotumor without AAS. Materials and methods The cases of seven patients (mean age 75.6 ± 7.6 years-old) with retro-odontoid pseudotumor without AAS were reviewed. The mean follow up time was 52.3 ± 25.5 months. Each patient underwent a C1 laminectomy with an additional C3-6 expansion laminoplasty in three patients. The Japanese Orthopaedic Association score (JOA score) was used for neurological assessment. Pseudotumor size and additional AAS were analyzed using MRI and radiography. Results All patients exhibited neurological improvement following surgery, the JOA score improved from 7.2 ± 3.2 to 14.1 ± 2.6. The mean O-C2 and C2-7 angle decreased from -3.2 ± 2.1°to -3.9 ± 1.7°, showing a slight kyphotic change. Postoperative AAS was not observed. All pseudotumors spontaneously resolved, and recurrence and regrowth were not observed. Five patients had MRIs after gadolinium administration; four patients who showed enhancement of the pseudotumor had almost complete reduction within 1 year following surgery.Discussion Our study, assessing the outcome of C1 laminectomy for retro-odontoid pseudotumor, found neurological improvement in all cases. Since all pseudotumors were reduced and additional AAS was not observed, C1 laminectomy for retro-odontoid pseudotumor, in the absence of AAS, is recommended as a therapeutic strategy.

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Section: Discussionsupporting

confidence: 57%

C1 laminectomy for retro-odontoid pseudotumor without atlantoaxial subluxation: review of seven consecutive cases

et al. 2013

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“…8,10,11 Interaction between activated macrophages and disc tissue leads to generation of inflammatory cytokines. 7 These cytokines and catabolic enzymes are then involved in the induction of angiogenesis, 7,8,27 and the new blood vessels formed conduct new molecules into 1 degrading HNP tissue.…”

Section: Anova Tablesmentioning

confidence: 99%

Determinants of Spontaneous Resorption of Intervertebral Disc Herniations

Autio¹,

Karppinen²,

Niinimäki³

et al. 2006

Spine

173

126

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“…6 Immunohistologic studies of IVDH in the human lumbar spine suggest that exposure of the immune-privileged nucleus pulposus induces a lymphocyte mediated autoimmune response which may contribute to chronic inflammation and pain. [6][7][8][9] Subcutaneous injection of autologous nucleus pulposus in pigs has been shown to increase vascular permeability and attract significantly more leukocytes than fat and sham-injected controls. 10 Immunohistochemical analysis of the leukocyte population has shown activated T and B cells, indicating a specific immune response against the herniated nucleus pulposus.…”

Section: Discussionmentioning

confidence: 99%

Lumbar Cerebrospinal Fluid in Dogs with Type I Intervertebral Disc Herniation

Windsor

Vernau

Sturges

et al. 2008

Veterinary Internal Medicne

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Background: Cerebrospinal fluid (CSF) in dogs with Hansen type I intervertebral disc herniation (IVDH) is classically described as normal or mildly inflammatory with a predominance of large mononuclear cells or neutrophils in severe acute herniations. However, we have observed a moderate to marked pleocytosis with a predominance of lymphocytes in some dogs with IVDH.Hypothesis: Moderate to marked CSF pleocytosis occurs more commonly in dogs with type I IVDH than is reported in the literature. Lymphocytic predominance is more common than nonlymphocytic pleocytosis in dogs with chronic IVDH.Animals: Four hundred twenty-three client-owned dogs with type I IVDH. Methods: Retrospective study. Lumbar CSF of dogs with surgically confirmed type I IVDH was evaluated cytologically. Information obtained from medical records included signalment, prior clinical history, time from onset of signs to presentation, neurologic status, and intraoperative findings. Dogs with prior history and/or intraoperative evidence consistent with chronic IVDH before an acute herniation were termed acute-on-chronic (AOC).Results: Pleocytosis (4 5 cells/uL) was present in 51% of dogs, including 23% with cervical IVDH and 61% with thoracolumbar IVDH. Moderate or marked inflammation (! 20 cells/uL) was identified in the CSF of 51% of dogs with thoracolumbar IVDH and pleocytosis. A predominance of lymphocytes was significantly more common in dogs examined 4 7 days from onset of signs (P 5 .032) and in dogs with AOC IVDH (P 5 .0013).Conclusions and Clinical Importance: Moderate to marked CSF pleocytosis in dogs with type I IVDH is more common than previously reported. Lymphocytic pleocytosis is most common in dogs with chronic progression or AOC IVDH. Lymphocytic inflammation in the CSF of some dogs might suggest an immune-mediated response to chronically herniated disc material.

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Immunohistological study of intervertebral disc herniation of lumbar spine

Cited by 38 publications

References 9 publications

C1 laminectomy for retro-odontoid pseudotumor without atlantoaxial subluxation: review of seven consecutive cases

C1 laminectomy for retro-odontoid pseudotumor without atlantoaxial subluxation: review of seven consecutive cases

Determinants of Spontaneous Resorption of Intervertebral Disc Herniations

Lumbar Cerebrospinal Fluid in Dogs with Type I Intervertebral Disc Herniation

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