Immunohistopathologic Demonstration of Pleuropneumonia Associated with <i>Morganella morganii</i> in a Piglet

Ono, Masaaki; Namimatsu, Takanori; Ohsumi, Tatsuya; Mori, Masafumi; Okada, Mizue; Tamura, Kazumichi

doi:10.1354/vp.38-3-336

Cited by 10 publications

(15 citation statements)

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“…This bacterium has also been associated with infections in animals and with human animal bite wound infections, which suggests that M. morganii may also cause zoonotic infectious diseases (Ono et al, 2001; Choi et al, 2002; Abrahamian and Goldstein, 2011; Zhao et al, 2012; Di Ianni et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

Draft Genomic Analysis of an Avian Multidrug Resistant Morganella morganii Isolate Carrying qnrD1

et al. 2016

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Morganella morganii is a commensal bacterium and opportunistic pathogen often present in the gut of humans and animals. We report the 4.3 Mbp draft genome sequence of a M. morganii isolated in association with an Escherichia coli from broilers in Portugal that showed macroscopic lesions consistent with colisepticemia. The analysis of the genome matched the multidrug resistance phenotype and enabled the identification of several clinically important and potentially mobile acquired antibiotic resistance genes, including the plasmid-mediated quinolone resistance determinant qnrD1. Mobile genetic elements, prophages, and pathogenicity factors were also detected, improving our understanding toward this human and animal opportunistic pathogen.

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Section: Introductionmentioning

confidence: 99%

Draft Genomic Analysis of an Avian Multidrug Resistant Morganella morganii Isolate Carrying qnrD1

et al. 2016

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“…This animal succumbed 3 mo after transport and introduction to a new facility, and the possibly of stress associated with these events cannot be excluded as a contributing factor along with infection. A case of pleuropneumonia due to M. morganii in a piglet was reported by Ono et al (2001) with isolation of large numbers of bacteria from the lung. In this case, M. morganii were demonstrated in the necrotic areas of the lungs by immunohistochemistry.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, the distribution of bacterial antigens was closely correlated to the histological lesion. Ono et al (2001) also indicated that no other bacteria were isolated from lung tissue. In this case, considered porcine reproductive and respiratory syndrome virus (PRRSV), infection and transportation could be the underlying primary cause of the lung infection.…”

Section: Discussionmentioning

confidence: 99%

“…It is also considered a possible cause of swollen head syndrome in broiler chickens in Japan (Tanaka et al 1995). Respiratory infections associated with this bacterium have been described in piglets (Ono et al 2001), a jaguar (Choi et al 2002), a guinea pig (Vandenberge et al 2013), and a rabbit (Roels et al 2007). …”

Section: Resale or Republication Not Permitted Without Written Consenmentioning

confidence: 99%

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Fatal fibrino-hemorrhagic bronchopneumonia associated with Morganella morganii in a bottlenose dolphin: a case report

Elfadl¹,

Lee²,

Kim³

et al. 2017

Dis. Aquat. Org.

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A 5 yr old, 184 kg, and 262 cm total length female bottlenose dolphin Tursiops truncatus was found dead in a display after bloody discharge from the blowhole was observed 3 h prior to death. Pathological examination revealed fibrinous bronchopneumonia with prominent areas of necrosis (sequestra) and numerous Gram-negative bacilli within alveoli and in blood vessels of the lungs and liver and between muscle fibers. The cause of death was attributed to septicemia. Often, cases of fibrinous bronchopneumonia are characterized by bacteremia in the latter stages of infection, resulting in the death of the animal. Septicemia likely accounts for the ecchymoses and petechiae noted on the spleen, pancreas, forestomach, lungs, visceral peritoneum, and small intestine. Additional lesions included hemothorax, stable red frothy fluid in the trachea, and lymphoid depletion in the spleen and lymph nodes. Pure growth of Morganella morganii was isolated from the lungs, blood, liver, and blowhole mucosa. Sequencing of 16s rRNA of the isolated bacteria showed more than 99.6% identity with M. morganii strain FDAARGOS_172. To our knowledge, this is the first report of fatal fibrinonecrotizing bronchopneumonia associated with M. morganii infection in a cetacean.KEY WORDS: Gram-negative bacilli · 16s RNA · Lungs · Sequestra · Hemothorax Resale or republication not permitted without written consent of the publisherDis Aquat Org 127: [41][42][43][44][45][46][47] 2017 ( Thornton et al. 1998). It is also considered a possible cause of swollen head syndrome in broiler chickens in Japan (Tanaka et al. 1995). Respiratory infections associated with this bacterium have been described in piglets (Ono et al. 2001), a jaguar (Choi et al. 2002), a guinea pig (Vandenberge et al. 2013), and a rabbit (Roels et al. 2007). CLINICAL HISTORYA 5 yr old juvenile female bottlenose dolphin Tursiops truncatus with a body weight of 184 kg and a total length of 262 cm was transported from Japan to a new aquarium in South Korea. The dolphin was transferred by car from Wakayama to the port of Osaka, Japan (6 h journey including waiting time in the port), then ferried to Busan, Korea (19 h journey). Finally, the animal was transported to Ulsan Dolphinarium by car (3 h journey).Three months later the animal acutely developed signs of anorexia, slight fever, and abnormal vertical movement in the pool. Bloody discharge from the mouth and blowhole as well as bloody feces were observed 6 h prior to death. Fluids (0.9% NaCl 1000 ml, intraveneous [IV]) were administered with antibiotics, including enrofloxacin 900 mg (intramuscular [IM]), gentamicin 720 mg (IM), cefazolin 3500 mg (IV), and cimetidine 1000 mg (IV). MATERIALS AND METHODS Necropsy and histopathologyA full necropsy was performed 19 h after death, and representative samples from multiple organs were fixed in 10% neutral formalin and submitted for histopathological examination. An additional set of tissues were sampled and individually labeled for ancillary diagnostic studies. Slides were prepared ...

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“…are possible. M. morganii infections have been reported in a variety of domestic animals that are associated with humans, including broiler chickens, piglets, rabbits, and dairy calves [7][8][9][10][11][12][13][14]. It is noteworthy that M. morganii can live in the oral cavity of animals and thereby cause infections in humans via bites [3,[15][16][17].…”

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Prevalence and characterization of Morganella morganii in beef cattle from Sichuan Province, China

Tian¹,

Cai²,

Liu³

et al. 2020

Preprint

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Background Morganella morganii (M. morganii) is a member of the genera Morganella in the Enterobacteriaceae family.Methods To better understand the prevalence and characterization of M. morganii strains in cattle, 191 nasal swabs samples from beef cattle in Guang'an, Yibin, and Ziyang, Sichuan Province, China were collected. The presence of M. morganii in swabs was determined by PCR. Then positive swabs were processed by using bacterial isolation and identification. The M. morganii isolates were assayed for antimicrobial susceptibility and pathogenicity using a mouse model.Results The prevalence of Morgenella morganii in three cities was 10.5% (20/191). Three M. morganii strains (16GA7, 17GA61.2, and 17YB9) were isolated and identified from positive swabs samples. Phylogenetic analysis demonstrated that the 16S rRNA gene of M. morganii isolates could be clustered with known Genbank M. morganii strains. All three M. morganii strains were sensitive to penicillin-type and quinolone antibiotics, and were resistant to some cephalosporins, carbapenems, macrolide antibiotics and polymyxin B. Lesions in mice inoculated with M. morganii included pulmonary hemorrhage, thickened alveolar walls, and pulmonary inflammatory cell infiltration, although lesions varied by strain.Conclusion To the best of our knowledge, the present study is the first to report the prevalence of M. morganii in beef cattle. Through research on the M. morganii in beef cattle, it is found that mice were susceptible to M. morganii isolates, which can cause mice dead. However, the pathogenicity of M. morganii isolates on cattle still needs further study.

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Immunohistopathologic Demonstration of Pleuropneumonia Associated with Morganella morganii in a Piglet

Cited by 10 publications

References 6 publications

Draft Genomic Analysis of an Avian Multidrug Resistant Morganella morganii Isolate Carrying qnrD1

Draft Genomic Analysis of an Avian Multidrug Resistant Morganella morganii Isolate Carrying qnrD1

Fatal fibrino-hemorrhagic bronchopneumonia associated with Morganella morganii in a bottlenose dolphin: a case report

Prevalence and characterization of Morganella morganii in beef cattle from Sichuan Province, China

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