Immunohistopathologic features of surgically excised overhanging filtering bleb: myofibroblasts after filtration surgery—a case report

Lim, Su-Ho; Unoki, Noriyuki; Cheol, Soon

doi:10.1007/s00417-014-2639-x

Cited by 3 publications

(8 citation statements)

References 5 publications

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“…The conjunctival epithelium of the ltering bleb adheres to the corneal epithelium. In the case of large OFBs, the corneal epithelium and conjunctival epithelium can gradually fuse due to their long-term adhesion, but the bleb does not break through the Bowman membrane and enter the corneal stroma (Figure 2D and 2F) [4,5,8,16,17]. Most OFBs have a certain degree of mobility, and can be pushed easily.…”

Section: Discussionmentioning

confidence: 99%

“…(2) This thinning leads to excessive ltration or even leakage from the bleb[6, 18, 19], which then sags under the in uence of gravity [18,19] and the squeezing pressure of eyelid closure [19]. Several authors have reported that OFBs can be easily separated from the cornea during operation, blunt dissection is su cient to accomplish this separation without causing any damage to the corneal stroma [4,5,16,19,20]. Some authors [7] have found using ultrasound and pathological examinations that the Bowman membrane under the OFB remains intact, and no channel connected with the cavity of the conjunctival ltering bleb is present, which obviates the need for suturing after the resection of the bleb.…”

Section: Discussionmentioning

confidence: 99%

“…In patients with BMOC, the ltering bleb crosses the corneoscleral junction and enters the corneal region, causing a plugging sensation, tears, increased intraocular pressure (IOP), and other symptoms. In severe cases, the pupil is blocked, resulting in a decrease in the best-corrected visual acuity (BCVA) [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…In patients with BMOC, the bleb usually covers the corneal surface, has a clear boundary with the corneal stroma, and is easy to separate from the cornea. Most authors call this type of bleb as an overhanging ltering bleb (OFB) [4][5][6][7]. OFBs can be easily separated from the cornea during surgical resection, without injuring the corneal stroma.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological features of corneal invasion by filtering bleb

Shi

Zhou

Chen

et al. 2022

Preprint

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Purpose: : To describe the clinicopathological characteristics and explore the possible etiology of cornea invasion by filtering bleb (CIFB) after filtering surgery. Methods: We reviewed 22 patients treated for CIFB between March 2005 and March 2022. The patients were followed up for more than 1 year. Slit-lamp examination, optical coherence tomography (OCT), ultrasound biomicroscopy, and histopathological examination were performed to observe the morphology of the bleb and depth of corneal invasion. Depending on the severity of the lesion, treatments consisting of local massage, acupuncture separation, or surgical resection were administered. Results: The mean age of the patients was 56.3 ± 8.8 years. All patients underwent filtering surgery in the moderate or advanced stage of glaucoma. The filtering bleb was closely connected with the cornea, and its posterior boundary was locally adhered. Forward displacement of the internal opening of the filtering bleb was found in 4 of 7 surgically treated patients. OCT and pathological examination showed that the filtering blebs invaded the corneal stroma. Removal of the adhesion of the posterior boundary of the filtering bleb by different treatment methods successfully improved the patients’ conditions. Conclusion: Filtering blebs can invade the corneal stroma. Adhesion of the posterior boundary and forward displacement of the internal opening of the filtering bleb are the possible causes of CIFB. Removal of the adhesion of the posterior boundary of the filtering bleb can halt the progression of CIFB.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinicopathological features of corneal invasion by filtering bleb

Shi

Zhou

Chen

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…In patients with BMOC, the bleb usually covers the corneal surface, has a clear boundary with the corneal stroma, and is easy to separate from the cornea. Most authors call this type of bleb as an overhanging filtering bleb (OFB) [ 4 – 7 ]. OFBs can be easily separated from the cornea during surgical resection, without injuring the corneal stroma.…”

mentioning

confidence: 99%

Clinicopathological features of corneal invasion by filtering bleb

et al. 2023

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Purpose To describe the clinicopathological characteristics and explore the possible etiology of cornea invasion by filtering bleb (CIFB) after filtering surgery. Methods We reviewed 22 patients treated for CIFB between March 2005 and March 2022. The patients were followed up for more than 1 year. Slit-lamp examination, optical coherence tomography (OCT), ultrasound biomicroscopy, and histopathological examination were performed to observe the morphology of the bleb and depth of corneal invasion. Depending on the severity of the lesion, treatments consisting of local massage, acupuncture separation, or surgical resection were administered. Results The mean age of the patients was 56.3 ± 8.8 years. All patients underwent filtering surgery in the moderate or advanced stage of glaucoma. The filtering bleb was closely connected with the cornea, and its posterior boundary was locally adhered. Forward displacement of the internal opening of the filtering bleb was found in 4 of 7 surgically treated patients. OCT and pathological examination showed that the filtering blebs invaded the corneal stroma. Removal of the adhesion of the posterior boundary of the filtering bleb by different treatment methods successfully improved the patients’ conditions. Conclusion Filtering blebs can invade the corneal stroma. Adhesion of the posterior boundary and forward displacement of the internal opening of the filtering bleb are the possible causes of CIFB. Removal of the adhesion of the posterior boundary of the filtering bleb can halt the progression of CIFB.

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Fungal corneal ulcer after repair of an overhanging filtering bleb: A case report

Zhao,

Xu,

Yin

et al. 2023

World J Clin Cases

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In recent years, metabolomics research has become a hot spot in the screening and treatment of cancer. It is a popular technique for the quantitative characterization of small molecular compounds in biological cells, tissues, organs or organisms. Further study of the tumor revealed that amino acid changes may occur early in the tumor. The rapid growth and metabolism required for survival result in tumors exhibiting an increased demand for amino acids. An abundant supply of amino acids is important for cancer to maintain its proliferative driving force. Changes in amino acid metabolism can be used to screen malignant tumors and improve therapeutic outcomes. Therefore, it is particularly important to study the characteristics of amino acid metabolism in colorectal cancer. This article reviews several specific amino acid metabolism characteristics in colorectal cancer.

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Immunohistopathologic features of surgically excised overhanging filtering bleb: myofibroblasts after filtration surgery—a case report

Cited by 3 publications

References 5 publications

Clinicopathological features of corneal invasion by filtering bleb

Clinicopathological features of corneal invasion by filtering bleb

Clinicopathological features of corneal invasion by filtering bleb

Fungal corneal ulcer after repair of an overhanging filtering bleb: A case report

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