2017
DOI: 10.4172/1745-7580.1000141
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Immunoinformatics Predication and Modelling of a Cocktail of B- and T-cells Epitopes from Envelope Glycoprotein and Nucleocapsid Proteins of Sin Nombre Virus

Abstract: Sin Nombre virus is a category A pathogen with a reported mortality rate ranging from 30% to 50%. It was responsible for the 2012 Yosemite National Park outbreak. Until now, Specific therapy is not available for the treatment of HCPS caused by SNV. Despite many efforts to develop safe and effective vaccines against SNV, included conventional approaches as well as molecular vaccine approaches, to date there are no vaccines proven to be highly efficacious against SNV. In our study, we analyzed envelope glycoprot… Show more

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Cited by 2 publications
(1 citation statement)
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“…The principle of using a cocktail of B-and T-cell epitopes in the epitope-based vaccine to trigger humoral as well as cellular mediated immune responses is much promising to clear infection than humoral or cellular immunity alone, and it was applied before to enhance protection against different kind of infectious diseases [85,86] . In this study, the analysis of Fba1 protein revealed 11 effective epitopes for B cell (AYFKEH, VDKESLYTK and HVDKESLYTK) and T cell (AVHEALAPI, KYFKRMAAM, QTSNGGAAY, RMAAMNQWL, YFKEHGEPL, IRGSIAAAH, LFSSHMLDL and VVAALEAAR).…”
Section: Discussionmentioning
confidence: 99%
“…The principle of using a cocktail of B-and T-cell epitopes in the epitope-based vaccine to trigger humoral as well as cellular mediated immune responses is much promising to clear infection than humoral or cellular immunity alone, and it was applied before to enhance protection against different kind of infectious diseases [85,86] . In this study, the analysis of Fba1 protein revealed 11 effective epitopes for B cell (AYFKEH, VDKESLYTK and HVDKESLYTK) and T cell (AVHEALAPI, KYFKRMAAM, QTSNGGAAY, RMAAMNQWL, YFKEHGEPL, IRGSIAAAH, LFSSHMLDL and VVAALEAAR).…”
Section: Discussionmentioning
confidence: 99%