2018
DOI: 10.1002/jbm.a.36338
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Immunoisolating poly(ethylene glycol) based capsules support ovarian tissue survival to restore endocrine function

Abstract: A common irreversible adverse effect of life-saving anticancer treatments is loss of gonadal endocrine function and fertility, calling for a need to focus on post-treatment quality of life. Here, we investigated the use of poly(ethylene glycol)-vinyl sulfone (PEG-VS) based capsules to support syngeneic donor ovarian tissue for restoration of endocrine function in mice. We designed a dual immunoisolating capsule (PEG-Dual) by tuning the physical properties of the PEG hydrogels and combining proteolytically degr… Show more

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Cited by 28 publications
(24 citation statements)
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“…The choice of which 3D matrix to use for grafting of isolated follicles and cells is one of the most challenging and critical elements in the development of a bioengineered artificial ovary (Amorim 2011). Since its conception, both synthetic (Kim et al 2016, Day et al 2018, Mendez et al 2018) and natural (Dolmans et al 2007, Paulini et al 2016, Chiti et al 2016a polymers have been tested for the creation of an artificial ovary prototype. While synthetic materials (produced with chemical processes that do not commonly occur in nature) are more predictable in terms of degradation rate and mechanical properties (Asti & Gioglio 2014), studies have shown that natural polymers (biologically derived materials) constitute the matrix of choice for an artificial ovary (Amorim & Shikanov 2016).…”
Section: D Matrix To Encapsulate Isolated Preantral Follicles and Ovmentioning
confidence: 99%
“…The choice of which 3D matrix to use for grafting of isolated follicles and cells is one of the most challenging and critical elements in the development of a bioengineered artificial ovary (Amorim 2011). Since its conception, both synthetic (Kim et al 2016, Day et al 2018, Mendez et al 2018) and natural (Dolmans et al 2007, Paulini et al 2016, Chiti et al 2016a polymers have been tested for the creation of an artificial ovary prototype. While synthetic materials (produced with chemical processes that do not commonly occur in nature) are more predictable in terms of degradation rate and mechanical properties (Asti & Gioglio 2014), studies have shown that natural polymers (biologically derived materials) constitute the matrix of choice for an artificial ovary (Amorim & Shikanov 2016).…”
Section: D Matrix To Encapsulate Isolated Preantral Follicles and Ovmentioning
confidence: 99%
“…Ovarian tissue cryopreservation (OTC) requires removal of ovarian tissue that is processed into strips of tissue for cryopreservation through slow-freeze or vitrification techniques. Transplantation of this tissue has resulted in restoring hormones to induce or maintain cyclical hormones and has resulted in over 130 reported live births (Donnez and Dolmans 2017;Pacheco and Oktay 2017;Corkum et al 2019). While oncology patients comprise the majority of fertility preservation cases, clinics have begun to offer services to DSD patients that may have some immature gametes within their gonadal tissue (Finlayson et al 2017;Johnson et al 2017;Finney et al 2019).…”
Section: Recognition Of the Problemmentioning
confidence: 99%
“…Careful consideration of risks and benefits, individually structured counseling and close monitoring are needed for each woman who may want to use their ovarian tissue for primary prevention or postponing menopause. To summarize, cHRT in the form of stored ovarian tissue or ovarian cell constructs ( 41 , 48 , 49 ) could potentially be used at the onset of natural or induced menopause as an ideal time to institute preventative strategies that could potentially increase the quality and length of women's lives. However, this is again technical possible but not proven in a clinical setting with women in this age group, and it can be argued that pHRT should be preferred in all cases as it is the cheapest and simplest way to provide hormones, and no real evidence for the superiority of physiological hormone levels exists.…”
Section: Cell/tissue-based Hormone Replacement Therapy (Chrt)mentioning
confidence: 99%