Immunoliposomes in clinical oncology: State of the art and future perspectives

Merino, María; Zalba, Sara; Garrido, María J.

doi:10.1016/j.jconrel.2018.02.015

Cited by 83 publications

(50 citation statements)

References 142 publications

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“…Moreover, uptake of liposomes with a positive charge appears to be much higher than negative liposomes. Thus, negatively charged lipid liposomes are common to most FDA-approved liposome formulations (Bourquin et al 2018;Zamani et al 2018;Kraft et al 2014;Merino et al 2018).…”

Section: Liposomes: An Overviewmentioning

confidence: 99%

“…Only liposomes with such a diameter can easily escape from blood vessel capillaries that perfuse tissues, such as lung, heart, and kidney. On the other hand, particles less than 10 nm undergo renal filtration through the glomerular capillary wall and are not reabsorbed (Gao et al 2018;Kraft et al 2014;Merino et al 2018). Furthermore, cell uptake is most relevant to liposomes of 100-150 nm diameter.…”

Section: Liposomes: An Overviewmentioning

confidence: 99%

“…Furthermore, cell uptake is most relevant to liposomes of 100-150 nm diameter. The immune system phagocytosis is also important, since reduction of liposome diameter to 50 nm or below greatly reduces phagocytosis clearance (Kraft et al 2014;Merino et al 2018). Thus, liposomes within 50-100 nm, such as DaunoXome, avoid phagocytosis and have long blood circulation time (Olusanya et al 2018;Kraft et al 2014).…”

Section: Liposomes: An Overviewmentioning

confidence: 99%

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Nanomedicine review: clinical developments in liposomal applications

et al. 2019

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Background Many conventional drugs exhibit poor pharmacokinetics, limited bioavailability and a high toxicity, all of which restrain their use. To overcome these issues and improve the therapeutic indexes of the drug, the emergent fields of nanotechnology and nanomedicine have made significant progress in detection, diagnosis and treatment of several diseases at clinical level (Li et al. 2014; Yingchoncharoen et al. 2016; Signorell et al. 2018). In fact, thanks to nanoparticles and liposomes, it has been possible to decrease the toxicity and improve the pharmacokinetics parameters, such as distribution, increased circulation time, targeted controlled release, increased intracellular concentration, and

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Section: Liposomes: An Overviewmentioning

confidence: 99%

Section: Liposomes: An Overviewmentioning

confidence: 99%

Section: Liposomes: An Overviewmentioning

confidence: 99%

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Nanomedicine review: clinical developments in liposomal applications

et al. 2019

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“…Heparin is also a coating material stabilizing and protecting liposomes against adverse immune reactions [54], or, in presence of adjuvants, induces drug accumulation at the tumor site [55]. The above list is far from being exhaustive and indicates that steric stabilization, in conjunction with other contributions, is responsible for advanced applications in most fields of bio-medicine and molecular medicine [56][57][58][59][60].…”

Section: Biological Implicationsmentioning

confidence: 99%

Colloid Stability Influences on the Biological Organization and Functions

Mesa¹,

Risuleo²

2020

Colloid Science in Pharmaceutical Nanotechnology

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It is common to entities having sizes in the nano/micro-scale range be that, real or bio-intended systems, to undergo the action of many different forces, imparting them colloid stability. Ubiquitary electrostatic contributions, sometimes dominant, may overlap with steric stabilization ones; their combination effectively takes place in most cases. The two effects are jointly responsible, for instance, for the control of many phenomena such as: adhesion onto cells of alien agents, cellular separation during morpho-functional evolution, uptake of exogenous materials into cells and tissues. We evidence here, how the combination of these forces operates, and indicate the procedures leading to their effectiveness, when required for purposes inherent to biomimicry.

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“…Based on the size of the ULVs, they are further divided into small unilamellar vesicles (SUVs) of 20 to 100 nm diameter, medium unilamellar vesicles (MUVs), large unilamellar vesicles (LUVs) of larger than 100 nm diameter, and giant unilamellar vesicles (GUVs) of larger than 1,000 nm diameter [9]. Liposome-based carrier systems such as immunoliposomes, virosomes, stealth liposomes, and archaeosomes contain lipid bilayers that are biocompatible and may improve the solubility and stability of core materials [10][11][12][13].…”

Section: Liposomesmentioning

confidence: 99%

An Overview of Nanotechnology in Food Science: Preparative Methods, Practical Applications, and Safety

Park

Kwon³

et al. 2018

Journal of Chemistry

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As the researches to utilize nanotechnology in food science are advanced, applications of nanotechnology in various fields of the food industry have increased. Nanotechnology can be applied to the food industry for production, processing, storage, and quality control of foods. Nanomaterials, unlike conventional microscale materials, having novel characteristics can improve sensory quality of foods by imparting novel texture, color, and appearance. Nanotechnology has been used to design nanosensors for detection of harmful components in foods and a smart packaging system enabling to recognize food contamination very rapidly and sensitively. Nanoencapsulation is the most significant technology in food science, especially for bioactive compounds and flavors. Targeted delivery systems designed with nanoencapsulation can enhance bioavailability of bioactive compounds after oral administration. In addition, nanoencapsulation enables to control the release of flavors at the desired time and to protect the degradation of flavors during processing and storage. In this review, current applications of nanotechnology in food science including flavor control, enhancement of bioavailability of bioactive compounds, and detection of deleterious substances in foods are presented. Furthermore, this article overviews classification, preparative methods, and safety issues of nanomaterials for food science. This review will be of help to provide comprehensive information for newcomers utilizing nanotechnology to the food sector.

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Immunoliposomes in clinical oncology: State of the art and future perspectives

Cited by 83 publications

References 142 publications

Nanomedicine review: clinical developments in liposomal applications

Nanomedicine review: clinical developments in liposomal applications

Colloid Stability Influences on the Biological Organization and Functions

An Overview of Nanotechnology in Food Science: Preparative Methods, Practical Applications, and Safety

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