Immunolocalisation of endothelin-1 in human brain

Naidoo, Vinogran; Naidoo, Strinivasen; Raidoo, Deshandra M.

doi:10.1016/j.jchemneu.2004.03.007

Cited by 19 publications

(8 citation statements)

References 23 publications

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“…ET-1 protein and mRNA are present in human paraventricular nuclei and the dorsal motor nucleus of the vagus (240, 241, 522, 749). ET-1 mRNA is located in human medulla oblongata (520).…”

Section: Endothelin and The Nervous Systemmentioning

confidence: 99%

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Regulation of Blood Pressure and Salt Homeostasis by Endothelin

Kohan

Rossi

Inscho

et al. 2011

Physiological Reviews

373

459

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Endothelin (ET) peptides and their receptors are intimately involved in the physiological control of systemic blood pressure and body Na homeostasis, exerting these effects through alterations in a host of circulating and local factors. Hormonal systems affected by ET include natriuretic peptides, aldosterone, catecholamines, and angiotensin. ET also directly regulates cardiac output, central and peripheral nervous system activity, renal Na and water excretion, systemic vascular resistance, and venous capacitance. ET regulation of these systems is often complex, sometimes involving opposing actions depending on which receptor isoform is activated, which cells are affected, and what other prevailing factors exist. A detailed understanding of this system is important; disordered regulation of the ET system is strongly associated with hypertension and dysregulated extracellular fluid volume homeostasis. In addition, ET receptor antagonists are being increasingly used for the treatment of a variety of diseases; while demonstrating benefit, these agents also have adverse effects on fluid retention that may substantially limit their clinical utility. This review provides a detailed analysis of how the ET system is involved in the control of blood pressure and Na homeostasis, focusing primarily on physiological regulation with some discussion of the role of the ET system in hypertension.

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“…ET-1 protein and mRNA are present in human paraventricular nuclei and the dorsal motor nucleus of the vagus (240, 241, 522, 749). ET-1 mRNA is located in human medulla oblongata (520).…”

Section: Endothelin and The Nervous Systemmentioning

confidence: 99%

“…ET-1 mRNA is located in human medulla oblongata (520). ECE-1 has been mapped to these same areas (522, 816). ET-3 mRNA and peptide are found in more rostral brain regions (469, 748, 749).…”

Section: Endothelin and The Nervous Systemmentioning

confidence: 99%

Regulation of Blood Pressure and Salt Homeostasis by Endothelin

Kohan

Rossi

Inscho

et al. 2011

Physiological Reviews

373

459

View full text Add to dashboard Cite

show abstract

“…21 On the other hand, it has been demonstrated in previous studies that endothelin-1 is distributed in the central and peripheral nervous systems. 7,22 Endothelin-1 is widely distributed in spiral ganglion cells in the guinea pig and may play a role in auditory transmission. Spiral ganglion neurons are the primary sensory neurons which provide afferent innervation to cochlear hair cells and convey nerve impulses from the cochlear hair cells to the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

“…Once released, its actions are diverse, including vasoactivity, 2 the promotion of mitogenesis/hypertrophy of vascular myocytes, 3,4 profibrotic activity, 5 and the regulation of angiogenesis. distributed in the cardiovascular and noncardiovascular systems, 7 and also distributed in the endolymphatic sac, vestibule, stria vascularis, and spiral ganglion cells of the inner ear. [8][9][10] This distribution strongly suggests that endothelin-1 must play some meaningful role in the inner ear, but no details are currently known.…”

Section: Introductionmentioning

confidence: 99%

Endothelin‐1 gene polymorphism and hearing impairment in elderly Japanese

et al. 2009

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“…It has also been demonstrated that in cerebral blood vessels ET-1 is released and acts from the abluminal (adventitial) and not from the endoluminal side. Endothelin-1 accounts for the majority of pathobiological effects exerted by endothelins, including the above-mentioned neurological pathologies [4][5][6][7][8][9][10]. In most of the tissues endothelins are primarily produced by endothelium, but in human brain the astrocytes are the main source of ET-1, especially in the settings of neuroischaemic disorders.…”

Section: Endothelin-1 Concentrations In Peripheral Jugular and Azygmentioning

confidence: 99%

Endothelin-1 concentrations in the internal jugular and azygous veins in multiple sclerosis patients: the results of a pilot study

Simka¹,

Ludyga²,

Janas³

et al. 2014

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Objectives: In this pilot study we examined the potent vasoconstrictor, endothelin-1, in the blood of multiple sclerosis patients in the context of chronic cerebrospinal venous insufficiency hypothesis. For this purpose we measured endothelin-1 concentrations in blood samples that were obtained during selective catheterisation of the main veins draining the central nervous system: the internal jugular veins and the azygous vein. Material and methods:We measured endothelin-1 concentrations in peripheral blood in nine multiple sclerosis patients and five healthy controls. In multiple sclerosis patients this peptide was also evaluated in blood samples obtained from the internal jugular veins and azygous vein. Also, in five patients peripheral endothelin-1 levels were measured one and seven days after angioplasty for stenosed internal jugular veins. Results: We found similar concentrations of endothelin-1 in peripheral blood in multiple sclerosis patients and healthy controls, a higher endothelin-1 level in the upper part of right internal jugular veins, and unchanged concentrations of this peptide in peripheral blood following angioplasty. Conclusions: Considering the pilot nature of our trial and the small number of the patients and controls assessed, our findings should be interpreted with caution, but they may represent a useful framework for further research in this field. However, our study shows that it is unlikely that endothelin-1 circulating in the blood is responsible for the symptoms of multiple sclerosis.

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Immunolocalisation of endothelin-1 in human brain

Cited by 19 publications

References 23 publications

Regulation of Blood Pressure and Salt Homeostasis by Endothelin

Regulation of Blood Pressure and Salt Homeostasis by Endothelin

Endothelin‐1 gene polymorphism and hearing impairment in elderly Japanese

Endothelin-1 concentrations in the internal jugular and azygous veins in multiple sclerosis patients: the results of a pilot study

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