2012
DOI: 10.1111/j.1582-4934.2012.01627.x
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Immunolocalization and expression of small‐conductance calcium‐activated potassium channels in human myometrium

Abstract: Small-conductance calcium-activated potassium (SK3) channels have been detected in human myometrium and we have previously shown a functional role of SK channels in human myometrium in vitro. The aims of this study were to identify the precise localization of SK3 channels and to quantify SK3 mRNA expression in myometrium from pregnant and non-pregnant women. Myometrial biopsies were obtained from pregnant (n = 11) and non-pregnant (n = 11) women. The expression of SK3 channels was assessed using immunohistoche… Show more

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Cited by 51 publications
(52 citation statements)
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“…The remaining K Ca channels (SK and IK channels) are rarely found in smooth muscle cells, and we did not find any evidence for a role in lymphatic contractility. However, K Ca channels have been described in interstitial Cajal-like cells (SK3 channels) (12,21) and in lymphatic endothelial cells (32). The human thoracic duct possesses interstitial Cajal-like cells (5), but the functional data presented here suggest that these cells either do not have SK channels or that SK channels on these cells play no role in the spontaneous contractile activity of the tissue.…”
Section: H40mentioning
confidence: 55%
“…The remaining K Ca channels (SK and IK channels) are rarely found in smooth muscle cells, and we did not find any evidence for a role in lymphatic contractility. However, K Ca channels have been described in interstitial Cajal-like cells (SK3 channels) (12,21) and in lymphatic endothelial cells (32). The human thoracic duct possesses interstitial Cajal-like cells (5), but the functional data presented here suggest that these cells either do not have SK channels or that SK channels on these cells play no role in the spontaneous contractile activity of the tissue.…”
Section: H40mentioning
confidence: 55%
“…To date, the majority of studies have investigated TC in physiological conditions. Interestingly, it has been reported that SK‐3 channels were present in the myometrial TC and in skeletal muscle interstitium, TC appeared to be PDGFRβ‐positive . In our opinion, future studies on different pathologies will help shed light on the possible TC functions.…”
Section: Discussionmentioning
confidence: 71%
“…K Ca 2.3 channels are also present in nonneuronal tissues, including the vascular endothelium, urinary bladder smooth muscle, and cardiac tissue (Taylor et al, 2003;Chen et al, 2004;Rosenbaum et al, 2012). In many types of neurons, a prominent action of K Ca 2 channels is to generate a Ca 2+ -dependent afterhyperpolarization (AHP) of the membrane that follows a burst of action potentials.…”
Section: The K Ca 2 Family-small Conductance Channels Regulated mentioning
confidence: 99%