Immunolocalization of INSL3 in dog foetal Leydig cells and the LGR8 receptor in the gubernaculum testis

Arrighi, S.; Bosi, G.; Groppetti, D.; Aralla, Marina; Crémonesi, F.

doi:10.1007/s11259-009-9251-2

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“…The expression of INSL 3 in adult testes suggests its role in reproduction. A specific association of mutations in INSL 3 genes with bilateral cryptorchidism has been indicated in animals and human in recent years (Foresta & Ferlin, ; El et al ., ; Williams et al ., ; Arrighi et al ., ; Ivell & Anand‐Ivell, ; Bay et al ., ). However, only a few studies have analysed the relationship between spermatogenesis in men with INSL 3 (Amory et al ., ; Huang et al ., ,b; Assis et al ., ; Sagata et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Mutational screening of the INSL₃gene in azoospermic males with a history of cryptorchidism

Huang¹,

Jia

Sun

et al. 2016

Andrologia

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The insulin-like factor 3 (INSL3 ) gene encodes 131 amino acids, consisting of two exons. In human beings, mutations of this gene may lead to bilateral cryptorchidism and infertility. However, the role of INSL3 in male spermatogenesis still remains controversial. We have analysed the coding sequence of INSL3 by PCR and DNA sequencing in 97 azoospermic patients with a history of bilateral cryptorchidism (patient group) versus 49 males with obstructive azoospermia (control group). The G178A mutation, which were predicted to alter the protein sequence (alanine to threonine), was detected in the patient group but not in the control group. While synonymous mutations G27A and G126A were detected in the control group, each occurred only in a single sample. When the patient group were divided into two subgroups according to the testicular biopsy result: sperm+ subgroup (51 cases with spermatozoa can be detected) or sperm- subgroup (46 cases with spermatozoa could not be detected). The INSL3 G178A polymorphism was not significantly associated with spermatozoa or no spermatozoa in the testes of males with a history of bilateral cryptorchidism. In conclusion, the evidence suggests that mutations of INSL3 may not directly contribute to the damage of spermatogenesis in patients with bilateral cryptorchidism history.

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Section: Discussionmentioning

confidence: 99%

Mutational screening of the INSL₃gene in azoospermic males with a history of cryptorchidism

Huang¹,

Jia

Sun

et al. 2016

Andrologia

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show abstract

Immunolocalization of INSL3 in dog foetal Leydig cells and the LGR8 receptor in the gubernaculum testis

Cited by 1 publication

References 9 publications

Mutational screening of the INSL₃gene in azoospermic males with a history of cryptorchidism

Mutational screening of the INSL₃gene in azoospermic males with a history of cryptorchidism

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Immunolocalization of INSL3 in dog foetal Leydig cells and the LGR8 receptor in the gubernaculum testis

Cited by 1 publication

References 9 publications

Mutational screening of the INSL3gene in azoospermic males with a history of cryptorchidism

Mutational screening of the INSL3gene in azoospermic males with a history of cryptorchidism

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Mutational screening of the INSL₃gene in azoospermic males with a history of cryptorchidism

Mutational screening of the INSL₃gene in azoospermic males with a history of cryptorchidism