Immunolocalization of the p53 protein in a case of ameloblastic fibrosarcoma

De-Paula, Alfredo Maurício Batista; Neto, José Quaresma da Costa; Gusmão, Edson da Silva; Santos, Francis Balduíno Guimarães; Gomez, Ricardo Santiago

doi:10.1053/joms.2003.50030

Cited by 18 publications

(14 citation statements)

References 20 publications

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“…Immunohistochemical studies may facilitate differentiation of this lesion because p53, Bcl-2, vimentin, and Ki-67 have been shown to be expressed within the sarcomatous mesenchyme of AFS. 8,10,[15][16][17] Ameloblastoma consists of benign ameloblastomatous epithelium embedded within a paucicellular stroma. In ameloblastoma, AF, and AFS, the benign ameloblastomatous epithelium showed positive immunoreactivity for broad-spectrum keratin (AE1/ AE3) while maintaining negativity for p53.…”

Section: Discussionmentioning

confidence: 99%

Ameloblastic Fibrosarcoma: Report of a Case, Study of Immunophenotype, and Comprehensive Review of the Literature

Lai

Blanas

Higgins

et al. 2012

Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Ameloblastic Fibrosarcoma: Report of a Case, Study of Immunophenotype, and Comprehensive Review of the Literature

Lai

Blanas

Higgins

et al. 2012

Journal of Oral and Maxillofacial Surgery

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“…However, cases with well-defined radiolucency are uncommon (72). Maxillary lesions tend to show antral involvement with apparent erosion of the sinus walls and a propensity to invade adjacent soft tissues, the base of the cranium and intracranial and orbital tissues (12,62,78).…”

Section: Discussionmentioning

confidence: 99%

“…(4-6,9-13,16-113). Papers describing clinicopathological features similar to those described for AFS were included in the first instance (4,5,(9)(10)(11)(12)(13)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(28)(29)(30)32,(34)(35)(36)(37)(38)(39)42,43,(67)(68)(69)(70)(71)(72)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)91,…”

Section: Systematic Literature Reviewmentioning

confidence: 99%

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

et al. 2017

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Here is described a case of ameloblastic fibrosarcoma (AFS) affecting the posterior mandible of a woman who was treated surgically and recovered without signs of recurrence or metastasis after 12 years of follow-up. Tumor sections were immunostained for cell cycle, epithelial and mesenchymal markers. Immunohistochemical analysis evidenced high Ki-67 positivity in stromal cells (mean of 20.9 cells/High power field). Epithelial cells displayed strong positivity for p53, p63 and cytokeratin 19. In addition to the case report, a systematic review of current knowledge is presented on the AFS's clinical-demographic features and prognostic factors. Based on the review, 88/99 cases were diagnosed as AFS, 9/99 as ameloblastic fibro-odontosarcoma and 2/99 as ameloblastic fibrodentinosarcoma. All these lesions displayed very similar clinical-demographic and prognostic features. Moreover, the review provided evidence that first treatment, regional metastasis, distant metastasis and local recurrence were significant prognostic values for malignant odontogenic mesenchymal lesions. Based on the findings, segregation among ameloblastic fibrosarcoma, ameloblastic fibrodentinosarcoma and ameloblastic fibro-odontosarcoma seems illogical, considering all these lesions have similar predilections and outcomes.

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“…Increased immunohistochemical reactivity for p53 has been detected in ameloblastomas, keratocystic odontogenic tumors, ameloblastic carcinomas, primary intraosseous carcinomas, and ameloblastic fibrosarcomas (4,6,(28)(29)(30)(31)(32)(33)(34)(35)(36), although several studies have shown that p53 mutations are infrequent in these odontogenic tumors (35,(37)(38)(39)(40). In ameloblastomas and keratocystic odontogenic tumors, the association between p53 and apoptosis remains uncertain (4,6).…”

Section: Molecular Alterations In the Development And Progression Of mentioning

confidence: 99%

Molecular alterations in the development and progression of odontogenic tumors

Kumamoto

2010

Oral Med Pathol

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Odontogenic tumors are lesions derived from the elements of the tooth-forming apparatus and are found exclusively within the jawbones. This review presents a contemporary outline of our current understanding of the molecular and genetic alterations associated with the development and progression of odontogenic tumors, including apoptosis-related factors, telomerase, cell cycle regulators, growth factors, regulators of tooth development, hard tissue-related proteins, cell adhesion molecules, matrix-degrading proteinases, angiogenic factors, and osteolytic cytokines. It is hoped that better understanding of related molecular mechanisms will help to predict the course of odontogenic tumors and lead to the development of new therapeutic concepts for their management.

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Immunolocalization of the p53 protein in a case of ameloblastic fibrosarcoma

Cited by 18 publications

References 20 publications

Ameloblastic Fibrosarcoma: Report of a Case, Study of Immunophenotype, and Comprehensive Review of the Literature

Ameloblastic Fibrosarcoma: Report of a Case, Study of Immunophenotype, and Comprehensive Review of the Literature

Ameloblastic Fibrosarcoma: A Case Report and Literature Review

Molecular alterations in the development and progression of odontogenic tumors

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