IMMUNOLOGIC CHANGES DURING SPECIFIC TREATMENT OF THE ATOPIC STATE II. The Serum Immunoglobulin Levels in the Hay Fever Hyposensitization Treatment

Immunologic Changes During Specific Treatment of the Atopic State

“…Our results support the conclusions of some papers (7,9,13,14,18,19,20,21) that the main part of blocking activity of the sera may be concentrated in IgG. We have shown that there are differences in the binding and blocking activity of IgG associated with the heterogeneity of this immunoglobulin.…”

“…We have shown that there are differences in the binding and blocking activity of IgG associated with the heterogeneity of this immunoglobulin. As mentioned in our previous work (21), the type of hyposensitization technique has an influence which must be considered for obtaining the highest effect of the treatment. Until now there are very few experiences on the blocking activity of IgA, though just this immunoglobulin couid bave a principal importance for the local tolerance to allergen in the respiratory mucous membrane.…”

“…In the course of specific treatment of the atopic state an increase of serum antibodies regularly takes place and may be demonstrated by haemagglutination or other serologic reactions (11); unfortunately the majority of these types of antibodies is only roughly related to the clinical condition (i, 11). Recent results suggest that the population of blocking antibodies is connected mostly with IgG (7,9,13,14,18,19,20,21). In previous studies (19,20,21) we have demonstrated that the allergen binding capacity of IgG and IgA increases with the number of hyposensitization cures, and that the degree of the binding activity may be directly correlated to the clinical improvement.…”

“…Recent results suggest that the population of blocking antibodies is connected mostly with IgG (7,9,13,14,18,19,20,21). In previous studies (19,20,21) we have demonstrated that the allergen binding capacity of IgG and IgA increases with the number of hyposensitization cures, and that the degree of the binding activity may be directly correlated to the clinical improvement. This study intends to illustrate if isolated IgG, IgA, and IgM with the proved I2O allergen binding activity yield to the allergen blocking ability in the skin test as well.…”