Immunologic characterization of infiltrating cells in flare‐up reactions

Tosti, Antonella; Varotti, C; Minghetti, G; Bardazzi, Federico; Pileri, Stefano; Rivano, M.T.; Veronesi, S.

doi:10.1111/j.1600-0536.1986.tb01156.x

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Tosti et al [15] characterized the pheno types of the infiltrating cells in flare-up reac tions induced through active sensiti zation after patch testing with paminodiphenylamine in 10 subjects. The phenotypic composition of the dermal in filtrate in these subjects was similar to the subject described above, with a percentage analysis as follows (our figures in brackets): Leu-3a-positive: 68-81% (71%), Leu-lapositive: 19-32% (14%), OKT6-positive: 8-12% (Leu 6 10%) and OKMl-positive: 2-5% (Leu M3 5%).…”

Section: Discussionmentioning

confidence: 99%

Immunophenotyping of the Eczematous Flare-Up Reaction in a Nickel-Sensitive Subject

Gawkrodger

Mcvittie²,

Hunter³

1987

Dermatology

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An eczematous flare-up reaction, occurring at a previously involved site, which followed oral challenge with 5.6 mg of nickel in a 29-year-old nickel-sensitive woman, was biopsied and studied by immunohistochemistry. The cellular infiltrate in the dermis and epidermis at 8 days was predominantly of Leu 3a phenotype (helper/inducer T lymphocytes), with smaller numbers of Leu-2a-reactive (suppressor/cytotoxic) T lymphocytes. Many infiltrating cells were DR-positive. No increase in epidermal Leu-6-positive Langerhans cells was seen but Leu-6-reactive cells were noted in the dermal infiltrate. Keratinocytes showed some expression of class II antigen (mainly DR). In comparison with the 48-hour allergic patch test reaction, the eczematous flare-up site showed no increase in epidermal Langerhans cell numbers nor infiltration with macrophages, but the responses were similar since both showed a superficial T cell reaction in the skin.

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Section: Discussionmentioning

confidence: 99%

Immunophenotyping of the Eczematous Flare-Up Reaction in a Nickel-Sensitive Subject

Gawkrodger

Mcvittie²,

Hunter³

1987

Dermatology

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4‐Aminodiphenylamin [MAK Value Documentation in German language, 2013]

2013

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 55. Lieferung, Ausgabe 2013 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Final Report on the Safety Assessment of N-Phenyl-p-Phenylenediamine, N-Phenyl-p-Phenylenediamine Hydrochloride, and N-Pheny 1-p-Phenylenediamine Sulfate

1994

Journal of the American College of Toxicology

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N-Phenyl-p-Phenylenediamine and its sulfate and hydrochloride salts are aromatic amines. Whereas N-Phenyl-p-Phenylenediamine Sulfate is not currently reported to be used in cosmetics, N-Phenyl-p-Phenylenediamine and N-Phenyl-p-Phenylenediamine Hydrochloride are used as colorants in hair dyes/colors. Data evaluated are for N-Phenyl-p-Phenylenediamine and are extended to the sulfate and hydrochloride salts. The oral median lethal dose (LD!,) in rats ranged from 464 mgkg to 1,OOO mgkg. Acute oral toxicity studies in cats showed increased methemoglobin and Heinz body formation 3 2 5 m&g. Dose-dependent weight reductions were seen in rats fed 32,200 pprn for 90 days. Mice fed 14,700 ppm showed a similar response. CNS damage was observed in mice fed 35,OOO ppm for 91 weeks. Irritation and sensitization were both observed in guinea pigs, but no ocular initation was seen in rabbits. Oral administration to female rats showed no developmental toxicity in one study, but showed maternal and fetal toxicity and an increase in skeletal malformations in another. Dermal application of a hair dye formulation containing 2.0% N-Phenyl-p-Phenylenediamine to female rats and mice showed no developmental toxicity of any sort. No evidence of carcinogenicity was found in either male or female rats fed N-Phenyl-p-Phenylenediamine for 78 weeks, or in female mice fed up to 10,OOO ppm for 48 weeks. Male mice, however, showed a non-dose-dependent increased incidence of hepatocellular neoplasms. In another study, dermal application of a hair dye formulation containing 2.0% N-Phenyl-p-Phenylenediamine to male and female mice once a week for 23 months resulted in no increase in neoplasms compared to controls.Clinical data indicate that N-Phenyl-p-Phenylenediamine is a skin initant and can be a sensitizer. Sensitization reactions were more common among dermatitis patients who work as hairdressers. Products containing these ingredients are exempt from the principal adulteration provision of the Federal Food, Drug, and Cosmetic Act when the label bears a caution statement and instructions to perform a patch test to ascertain if the user is sensitive to them. Because this ingredient is a sensitizer, users should be screened with a patch test. On the basis of the information in this report, it is concluded that N-Phenyl-p-Phenylenediamine, N-Phenyl-p-Phenylenediamine Sulfate, and N-Phenyl-p-Phenylenediamine Hydrochloride are safe for use in hair dyes at concentrations up to 1.7% (as the free base).

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Immunologic characterization of infiltrating cells in flare‐up reactions

Cited by 3 publications

References 3 publications

Immunophenotyping of the Eczematous Flare-Up Reaction in a Nickel-Sensitive Subject

Immunophenotyping of the Eczematous Flare-Up Reaction in a Nickel-Sensitive Subject

4‐Aminodiphenylamin [MAK Value Documentation in German language, 2013]

Final Report on the Safety Assessment of N-Phenyl-p-Phenylenediamine, N-Phenyl-p-Phenylenediamine Hydrochloride, and N-Pheny 1-p-Phenylenediamine Sulfate

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