Immunologic Considerations of Patients with Brain Tumors

MahaleyJr., M. S.; Gillespie, G. Yancey

doi:10.1007/978-1-4613-3858-1_6

Cited by 4 publications

(1 citation statement)

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“…A study utilizing a-interferon has been performed by the Pediatric Oncology Group, but results have not yet been reported. Mahaley and Gillespie [14] also treated 15 adults with recurrent cerebral gliomas with y-interferon. One patient, with an oligodendroglioma, responded to intravenous yinterferon, while 3 other patients with high-grade gliomas experienced stable disease.…”

Section: Restorative Immunotherapymentioning

confidence: 99%

Alternative Therapies for Children with Brain Stem Gliomas: Immunotherapy and Gene Therapy

Packer¹

1996

Pediatr Neurosurg

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Alternative means are needed for the treatment of childhood brain stem gliomas. Both immunotherapy and gene therapy have and will be, in the future, evaluated for these patients. Results, to date, with immunotherapy have been sparse and variable. Restorative immunotherapy, especially the use of β-interferon, has shown some promising results. However, in one recently completed trial, the combination of β-interferon plus hyperfractionated radiotherapy in newly diagnosed patients did not apparently result in improved survival. Gene therapy, still in its infancy, also may be potentially applicable to the treatment of children with brain stem gliomas.

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Section: Restorative Immunotherapymentioning

confidence: 99%